Method for extracting tabersonine from voacanga africana

A technology of African potato fruit and tabonin, which is applied in organic chemistry and other fields, can solve problems such as complex processes, and achieve the effect of simple extraction process and avoiding damage

Active Publication Date: 2018-09-04
太阳树(厦门)生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process has disadvantages such as complicated process
The invention patent with application number 201110237688.1 discloses a preparation process of alkaloid tabonin, which uses xylene heating extraction, acid water extraction, acid water purification, alkalization extraction and other steps, and the process is complicated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. The raw material is crushed, and 2 kg of African potato seeds are taken and crushed until the particle size is 10-20 mesh. According to the determination of the seeds of African potato fruit, the content of other bonin is about 1.6%.

[0022] 2. Soaking, put the pulverized African potato seeds into a sulfuric acid solution with a mass fraction of 2% and soak for 24 hours.

[0023] 3. Percolation: Put the soaked African potato seeds in the percolation tube, continuously add sulfuric acid solution with a mass fraction of 2% from the upper part, and the flow rate is 2BV / h, and collect the percolation liquid until the percolation liquid content ≤0.2mg / ml, stop collecting.

[0024] 4. Filtration: Filter the obtained percolate until it is clear and translucent.

[0025] 5. Column chromatography: (1) The obtained filtrate is adsorbed by macroporous resin with a flow rate of 2BV / h.

[0026] (2) When the content of the effluent is ≥0.2mg / ml, rinse the resin with 2L of wate...

Embodiment 2

[0031] 1. The raw material is crushed, and 2 kg of African potato seeds are taken and crushed until the particle size is 10-20 mesh. According to the determination of the seeds of African potato fruit, the content of other bonin is about 1.6%.

[0032] 2. Soaking, put the pulverized African potato seeds into a sulfuric acid solution with a mass fraction of 4% and soak for 12 hours.

[0033] 3. Percolation: Put the soaked African potato seeds in the percolation tube, continuously add sulfuric acid solution with a mass fraction of 4% from the upper part, and the flow rate is 1BV / h, and collect the percolate until the percolate reaches the content of percolation. ≤0.2mg / ml, stop collecting.

[0034] 4. Filtration: Filter the obtained percolate until it is clear and translucent.

[0035] 5. Column chromatography: (1) The obtained filtrate is adsorbed by macroporous resin at a flow rate of 1BV / h.

[0036] (2) When the content of the effluent is ≥0.2mg / ml, rinse the resin with 2L...

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Abstract

The invention discloses a method for extracting tabersonine from voacanga africana. The method comprises the following steps: S1, crushing a raw material; S2, soaking, namely soaking crushed voacangaafricana fruit seeds into a 2-4% sulfuric acid solution; S3, performing percolation, namely putting the soaked voacanga africana fruit seeds into a percolation tube, continuously adding the sulfuric acid solution from an upper part, and collecting a percolation liquid; S4, filtering, namely filtering the obtained percolation till the filtrate is clear and transparent; S5, performing column chromatography, namely adsorbing the filtrate with a macroporous resin, washing the resin with water when the content of an effluent is greater than or equal to 0.2mg/ml, and collecting a desorption liquid,wherein a 65-75% ethanol solution is adopted as a desorption solvent; S6, performing concentration centrifugation, namely concentrating the desorption liquid, adjusting a pH value, leaving to stand, and performing centrifugation, so as to obtain a product. The method disclosed by the invention is simple and convenient to operate, environmentally-friendly and high in extraction recycling rate.

Description

technical field [0001] The invention relates to the technical field of plant extraction, in particular to a method for extracting tabonin from African potato fruit. Background technique [0002] African potato fruit is a kind of Apocynaceae plant produced in Africa. Its main components are bonin and ibogaine, and it also contains polysaccharides, flavonoids, volatile oils and other chemical components. Taboning has a variety of medicinal effects: antihypertensive effect, anti-tumor effect, hypoglycemic effect, diuretic effect, and is used for depression, anxiety, and emotional instability caused by stroke sequelae, ischemic hypertensive encephalopathy, and cerebrovascular disease. It is suitable for the relief of symptoms of premature dementia. [0003] The invention patent with the application number 201310613225.X discloses a process for extracting tabonin from potato fruit. The potato seed is ultrafinely pulverized, then added with ethyl acetate and centrifuged with ethy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/20
CPCC07D471/20
Inventor 陈义刘裕陈强
Owner 太阳树(厦门)生物工程有限公司
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