An analgesic and sleeping aid capsule and its preparation method

A sleep aid and capsule technology, which is applied in capsule delivery, medical formula, non-central analgesics, etc., can solve the problems of treating the symptoms but not the root cause, and increasing the dosage of melatonin, so as to relieve pain, obtain materials easily, and ensure product quality Effect

Active Publication Date: 2020-02-18
GUIZHOU SHENQI PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its functional ingredient is melatonin, which only helps patients fall asleep through the sleeping effect of melatonin. For patients with diseases and severe body pain who cannot fall asleep, the pain cannot be relieved. Forcibly helping sleep requires increasing melatonin Excessive use of melatonin will cause the patient to feel dizzy and dizzy after getting up the next morning, and the pain in the body will not disappear, so that the treatment can only treat the symptoms but not the root cause

Method used

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  • An analgesic and sleeping aid capsule and its preparation method

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Effect test

Embodiment 1

[0021] Embodiment 1: capsule preparation

[0022] Take 300g of phoenix clothes and add 20 times the mass of water, extract at 100°C for 4h, then centrifuge at 3500r / min for 25min, take the supernatant, add 8 times the mass of water to the filter residue, extract at 100°C for 1h, and then Centrifuge at 3500r / min for 25min, take the supernatant, combine the two filtrates to obtain a mixed extract; place the mixed extract in a rotary evaporator at 70°C, evaporate and concentrate to 1 / 10 of the volume of the original mixed extract; Add trypsin with a mass ratio of 2% to hydrolyze the product for 4 hours, spray the hydrolyzed product at an air inlet temperature of 230°C, and a pump speed of 65r / min to obtain phoenix clothes hydrolyzed powder, then add 0.0025g of melatonin, mix evenly, and After sterilization under 30W ultraviolet lamp for 40min, the capsules were filled under aseptic conditions.

Embodiment 2

[0023] Embodiment 2: capsule preparation

[0024] Take 500g of phoenix clothes and add 25 times the mass of water, extract at 100°C for 4h, then centrifuge at 3700r / min for 25min, take the supernatant, add 9 times the mass of water to the filter residue, and extract at 100°C for 1.5h, Afterwards, centrifuge at 3700r / min for 25min, take the supernatant, and combine the two filtrates to obtain a mixed extract; place the mixed extract in a rotary evaporator at 75°C, evaporate and concentrate to 1 / 15 of the volume of the original mixed extract; The concentrate was hydrolyzed by trypsin with a mass ratio of 2.5% for 4 hours, and the hydrolyzed product was spray-dried at an air inlet temperature of 270°C and a pump speed of 70r / min to obtain Phoenix clothes hydrolyzed powder, then added 0.0025g of melatonin, and mixed well , After sterilizing under 33W ultraviolet lamp for 38min, the capsules were filled under aseptic conditions.

Embodiment 3

[0025] Embodiment 3: capsule preparation

[0026] Take 600g of phoenix clothes and add 30 times the mass of water, extract at 100°C for 3h, then centrifuge at 4000r / min for 30min, take the supernatant, add 10 times the mass of water to the filter residue, extract at 100°C for 1h, and then Centrifuge at 4000r / min for 30min, take the supernatant, combine the two filtrates to obtain a mixed extract; place the mixed extract in a rotary evaporator at 80°C, evaporate and concentrate to 1 / 20 of the volume of the original mixed extract; Add mass ratio of 3% trypsin to hydrolyze the product for 3 hours, spray the hydrolyzed product at an air inlet temperature of 280° C., and a pump speed of 80 r / min to obtain phoenix clothes hydrolyzed powder, then add 0.002 g of melatonin, mix well, After sterilizing under 35W ultraviolet light for 35min, the capsules were filled under aseptic conditions.

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Abstract

The invention provides health capsules capable of alleviating pain and promoting sleep and a preparation method thereof. The health capsules are prepared from the raw materials of 300-600 parts of gallus gallus domesticus brisson and 0.002-0.003 part of melatonin. The preparation method comprises the step of hydrolyzing the gallus gallus domesticus brisson to enable active components of the gallusgallus domesticus brisson to be released, so that the utilization rate of effective components of the gallus gallus domesticus brisson is increased. The source of raw material of the gallus gallus domesticus brisson is easy and convenient to obtain, high in yield, and low in cost, so that the cost of products can be greatly reduced. The hydrolyzed components of the gallus gallus domesticus brisson and the melatonin are compounded and researched, so that the consumption of the melatonin can be reduced, for patients suffering from diseases and pains and being unable to sleep, the diseases and the pains can be alleviated, and the patients can go to sleep peacefully. The health capsules do not influence the mind state of the patients the next day, and the effect of thoroughly treating the diseases can be achieved. In addition, the detection method can simply, quickly and effectively detect the health capsules, and the product quality can be guaranteed.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to an analgesic and sleep-stimulating capsule and a preparation method thereof. Background technique [0002] Melatonin, also known as melatonin and pineal gland, is a neurohormone mainly secreted by the pineal gland of mammals, and other tissues other than the pineal gland also secrete the substance. American dermatologists isolated and proved its biological activity from bovine pineal gland extract for the first time. Melatonin has a wide range of physiological and pharmacological activities. Its main role is to regulate circadian rhythm, sleep-wake biological rhythm phase transition, improve sleep, and also has anti-oxidation, free radical scavenging, anti-inflammation, anti-apoptosis, lower body temperature, and tumor inhibition. Growth, inhibition of reproductive system function, improvement of memory, treatment of dementia, anti-aging, anti-anxiety, impr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4045A61K35/57A61K9/48A61P29/00A61P25/20
CPCA61K9/48A61K31/4045A61K35/57A61P25/20A61P29/00A61K2300/00
Inventor 张芝庭张涛涛
Owner GUIZHOU SHENQI PHARMA RES INST
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