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Cutaneous penetration plaster for treating cold of children and preparation method of cutaneous penetration plaster

A technology for transdermal drug delivery and plaster, which can be applied to pharmaceutical formulations, medical formulations with inactive ingredients, and medical formulations containing active ingredients, etc. problems, to maintain the maintenance of drug efficacy, prevent skin damage, and achieve the effect of good mildness

Inactive Publication Date: 2018-10-12
CHENDU NEW KELI CHEM SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] It can be seen that in the application of transdermal drug delivery in the prior art, there are difficulties in the transdermal drug delivery of macromolecular drugs, and the excessive use of penetration enhancers, iontophoresis, etc., is easy to cause damage to the skin of patients, especially infants and young children. Certain side effects, poor safety and other disadvantages

Method used

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  • Cutaneous penetration plaster for treating cold of children and preparation method of cutaneous penetration plaster
  • Cutaneous penetration plaster for treating cold of children and preparation method of cutaneous penetration plaster
  • Cutaneous penetration plaster for treating cold of children and preparation method of cutaneous penetration plaster

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Mix 9kg of Bupleurum bupleurum, 7kg of Artemisia annua, 9kg of forsythia, 6kg of Platycodon grandiflorum, 7kg of Folium Isatidis, 39kg of Radix Radix, and 23kg of licorice, distill, filter, collect volatile oil and distillate, and further concentrate to obtain a concentrated product with a solid content of 66%. paste; then mix 49kg concentrated paste with 21kg honey, 13kg seabuckthorn fruit, 3kg polyvinylpyrrolidone, 3kg lauramide propyl betaine, use 4kg glycerin, 4kg octenyl succinic acid starch ester, 5kg polyvinyl alcohol to adjust the paste The body viscosity reaches 270Pa·s; finally, the paste is coated on the polyvinyl chloride film with an average thickness of 70 μm, and further covered with a polyethersulfone film to isolate the zein protective layer, so as to obtain a transdermal drug for treating colds in children plaster.

[0031] testing method:

[0032] (1) Skin irritation test: 100 white guinea pigs were selected as test subjects, half male and half femal...

Embodiment 2

[0041]Mix 7kg of Bupleurum bupleurum, 6kg of Artemisia annua, 7kg of forsythia, 5kg of Platycodon grandiflorum, 6kg of Folium Isatidis, 49kg of Radix Radix, and 20kg of licorice, distill, filter, collect volatile oil and distillate, and further concentrate to obtain a concentrated solid content of 60%. paste; then mix 56kg concentrated paste with 18kg honey, 12kg seabuckthorn fruit, 2kg polyvinylpyrrolidone, 2kg lauramide propyl betaine, use 3kg glycerin, 3kg octenyl succinic acid starch ester, 4kg polyvinyl alcohol to adjust the paste The body viscosity reaches 250Pa·s; finally, the paste is coated on the polypropylene film, with an average thickness of 20 μm, further covered with a polyvinylidene fluoride film, and isolated from the protective layer of zein, to prepare a transdermal drug for treating colds in children plaster.

[0042] The test method is consistent with Example 1, and the obtained data are shown in Table 1.

Embodiment 3

[0044] Mix 10kg of Bupleurum bupleurum, 8kg of Artemisia annua, 10kg of forsythia, 7kg of platycodon, 8kg of Folium Isatidis, 32kg of Radix Isatidis, and 25kg of licorice, distill, filter, collect volatile oil and distillate, and further concentrate to obtain a concentrated product with a solid content of 70%. paste; then mix 36kg concentrated paste with 25kg honey, 15kg seabuckthorn fruit, 4kg polyvinylpyrrolidone, 4kg lauramide propyl betaine, use 5kg glycerin, 5kg octenyl succinic acid starch ester, 6kg polyvinyl alcohol to adjust the paste The body viscosity reaches 300Pa·s; finally, the paste is coated on a polyethylene film with an average thickness of 100 μm, further covered with a polyacrylonitrile film to isolate the protective layer of zein, and a transdermal drug delivery patch for treating colds in children is obtained paste.

[0045] The test method is consistent with Example 1, and the obtained data are shown in Table 1.

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Abstract

The invention belongs to the technical field of medical plasters, and provides a cutaneous penetration plaster for treating cold of children and a preparation method. The cutaneous penetration plasteris prepared by smearing and laminating ointment prepared from radix bupleuri, sweet wormwood herb, fructus forsythiae, radix platycodonis, folium isatidis, radix isatidis, licorice root, honey, fructus hippophae, polyvinylpyrrolidone, lauramidopropyl betaine, glycerinum, octenyl succinic acid modified starch and polyvinyl alcohol. Compared with the traditional method, the prepared cutaneous penetration plaster is moderate to the skin, has good efficacy for clearing away the internal heat and removing the toxicity, is good in storage stability and drug effect retaining performance, can achievean effect of effective slow release, is free from side effect and good in safety, can be used for treating the cold of children caused by wind heat, can be optimally adhered on the belly, has durabledrug effect and is very convenient to use.

Description

technical field [0001] The invention belongs to the technical field of medical plasters, and provides a transdermal drug plaster for treating colds in children and a preparation method thereof. Background technique [0002] In recent years, local transdermal drug delivery has become more and more widely used. It is mainly a drug delivery method through skin absorption, which means that after the drug is applied to the skin, it passes through the stratum corneum, diffuses through the skin, and initiates the treatment of diseases locally or systemically. role. Compared with traditional oral or injection administration, transdermal administration has many advantages, such as maintaining effective drug concentration through continuous transdermal action, reducing toxic and side effects, avoiding drug degradation and absorption in the gastrointestinal tract, and improving drug delivery. Utilization rate, patients can self-administer medication or withdraw medication at any time....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/855A61K36/704A61K36/634A61K9/70A61K47/10A61K47/36A61K47/32A61K47/46A61K47/18A61P11/00
CPCA61K36/855A61K9/7038A61K9/7046A61K9/7053A61K36/195A61K36/233A61K36/282A61K36/315A61K36/346A61K36/484A61K36/634A61K36/704A61K47/183A61K47/46A61P11/00A61K2300/00
Inventor 陈庆曾军堂
Owner CHENDU NEW KELI CHEM SCI CO LTD
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