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Polypeptides for inhibiting complement activation

An inhibitory and complement system technology, applied in complement proteins, fusion polypeptides, targeting specific cell fusion, etc., can solve problems such as unstudied long-term effects of deposition

Active Publication Date: 2018-10-23
艾丽法有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Until now, the long-term effects of these deposits have not been studied

Method used

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  • Polypeptides for inhibiting complement activation
  • Polypeptides for inhibiting complement activation
  • Polypeptides for inhibiting complement activation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0092] MFHR1 consists of the N-terminal FH regulatory activity domain SCR1-4 (C3 / C5 convertase decay acceleration and cofactor activity) and the C-terminal surface recognition domain of FH (SCR19-20) and the N-terminal domain of FHR1 ( SCR1-2) consists of [ figure 1 ]. FHR1 is the only known endogenous complement regulator of the C5 convertase. FHR1 SCR1-2 binds C5 and thereby inhibits the cleavage of C5 into C5a and C5b. Additionally, FHR1 SCR1-2 inhibits the terminal complement pathway by binding to C5b6. Through the combination of these domains, complement activation is inhibited at multiple effector sites of the cascade (C3b degradation, inhibition of C3 / C5 convertase, inhibition of C5 cleavage and C5b-9 formation). This also leads to the inhibition and formation of anaphylatoxins C3a and C5a, which are thought to promote disease progression in AP-associated diseases.

[0093] To prepare MFHR1, a cDNA fragment containing the requested sequence of the above-mentioned F...

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Abstract

The invention relates to a polypeptide comprising a C3 convertase effector domain, a C5 convertase effector domain and optionally a terminal complex inhibitory effector domain which is resistant to deregulation by physiologic FHR-Proteins und has a dimerization motif, and to its therapeutic use.

Description

Background of the invention [0001] The complement system is an integral part of innate immunity and helps to recognize and eliminate pathogens, clear apoptotic cells or immune complexes, and regulate adaptive immune responses (Ricklin et al., 2010, Carroll et al., 2011). Complement is composed of a variety of plasma proteins (produced primarily by the liver), usually circulating as zymogens or membrane proteins and acting in plasma, tissues or cells. Activation of the three complement pathways, the classical pathway (CP), the lectin pathway (LP), or the alternative pathway (AP), each leads to the formation of a C3 convertase (C4b2a in CP, LP, or C3bBb in AP) , the enzyme catalyzes the cleavage of C3, the core component of the complement system, into the activation product C3b and the allergic peptide C3a. Subsequently and in a cascade of triggered responses, the pathogen is marked for destruction and a series of inflammatory responses are induced, recruiting immune cells to f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/47
CPCC07K14/472A61P13/02A61P13/12A61P17/02A61P27/02A61P29/00A61P31/00A61P31/04A61P37/02A61P37/06A61P7/02A61P9/10A61K47/66C07K2319/00C07K2319/33C07K2319/70A61K38/00C07K2319/74
Inventor D.麦可费德K.哈弗纳
Owner 艾丽法有限责任公司
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