Sample transfer device and method for sample transfer

Abstract

A sample transfer device (110), an analytical system (192) for analyzing a sample, a method for sample transfer and a method for manufacturing the sample transfer device are disclosed. The sample transfer device (110) comprises: at least one first block (112) and at least one second block (114), wherein the first block (112) comprises at least one first port (118) and at least one second port (120), wherein the second block (114) comprises at least one third port (122) and at least one fourth port (124); at least one slider (116), wherein the slider (116) is located between the first block(112) and the second block (114), wherein the slider (116) is configured to slide from a first position to a second position and vice versa; wherein both in the first position and in the second position a first straight channel (126) is formed between the first port (118) and the third port (122) and a second straight channel (128) is formed between the second port (120) and the fourth port (124).

Description

technical field [0001] The invention relates to a sample delivery device, an analysis system for analyzing a sample, a method for sample delivery and a method for manufacturing a sample delivery device. The device and method according to the invention can be used in particular for multidimensional separation of samples and in the field of high-throughput testing of molecules. In particular, the device and the method according to the invention can be applied in the field of bioanalysis, in particular in the field of proteomics and metabolomics. Other applications are also possible. Background technique [0002] Various electromigration separation techniques are used in the field of bioanalysis, especially in the fields of proteomics and metabolomics. Many of these techniques are also commonly applied in the field of pharmaceuticals and biopharmaceuticals, in particular for the analysis of proteins, in particular antibodies, charge variants or other proteoforms. In particul...

AI Technical Summary

Problems solved by technology

[0009] Despite the advantages and advances achieved by the developments mentioned above, some significant technical challenges remain

Therefore, in general, known techniques for sample delivery often imply challenges with tightness and leakage

Furthermore, known systems and devices are often mechanically unstable, which can often lead to material wear and / or voltage drop

Furthermore, it is often challenging to precisely transport samples from the first to the second dimension while maintaining high separation efficiencies of electromigration separation techniques, especially since the small size and / or high The need for electrical separation

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