Lipids and complexes for the delivery of biologically-active material to cells

A technology of complexes and ionic compounds, which can be used in drug combinations, allergic diseases, medical preparations with inactive ingredients, etc., and can solve problems such as reducing transfection efficiency
CN108779063AActive Publication Date: 2018-11-09RYBOQUIN COMPANY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
RYBOQUIN COMPANY
Publication Date
2018-11-09

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Abstract

A lipid comprising a tri-chain cation of formula (la) having a cationic head group and three C12-24 hydrocarbyl groups for use in non-viral gene delivery systems, for example in the formation of lipopolyplex transfection vectors. Exceptionally good nucleic acid transfection is observed when nucleic acid and targeting peptides are formulated with the lipid of the invention (or lipid formulated witha co-lipid) into a LPD complex.
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Description

field of invention

[0001] The present invention relates to lipid derivatives suitable for use in the delivery of biologically active substances (eg, nucleic acids, proteins or small molecules) to cells. The invention also relates to complexes for use in the preparation of non-viral vectors for the delivery of biologically active substances to cells, said complexes comprising such lipids, such lipids in combination, for example, with peptides, and such complexes Use in eg prophylaxis, therapy and vaccination or in an in vitro laboratory setting. Background of the invention

[0002] Gene delivery for therapeutic or other purposes is well known, especially for the treatment of diseases such as cystic fibrosis and certain cancers. The term refers to the delivery of a gene or part of a gene into a cell to correct some defect. In this specification, the term is also used to refer to any introduction of nucleic acid material into target cells, and includes both genetic vaccinatio...

Claims

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