Application of rhizoma chuanxiong total alkaloids in preparation of medicine for regulating uterine smooth muscle

A technology of uterine smooth muscle and total alkaloids, applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., to achieve the effect of treating dysmenorrhea, good clinical application prospects, and reducing contraction vitality

Inactive Publication Date: 2018-11-13
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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There is no literature report that Chuanxiong alkaloids

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  • Application of rhizoma chuanxiong total alkaloids in preparation of medicine for regulating uterine smooth muscle
  • Application of rhizoma chuanxiong total alkaloids in preparation of medicine for regulating uterine smooth muscle
  • Application of rhizoma chuanxiong total alkaloids in preparation of medicine for regulating uterine smooth muscle

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[0030] Example 1 Preparation method of Ligusticum chuanxiong total alkaloids of the present invention

[0031] (1) Take the crude Ligusticum chuanxiong powder, extract it with 15 times the weight of Ligusticum chuanxiong 80% v / v ethanol, and recover the solvent to obtain the ethanol extract for use;

[0032] (2) Take the ethanol extract of step (1) and dissolve it with 60 mL of 1mol / L hydrochloric acid, filter, and adjust the pH of the filtrate to 9-10 with concentrated ammonia, then extract with chloroform until it is colorless, combine the chloroform extracts, concentrate and evaporate to dryness. That is the total alkaloids of Ligusticum chuanxiong.

[0033] The following specific pharmacodynamic experiments prove the beneficial effects of the present invention:

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Abstract

The invention provides application of rhizoma chuanxiong total alkaloids in the preparation of medicine for regulating the uterine smooth muscle. The rhizoma chuanxiong total alkaloids can evidently lower the contracting activity, contracting tension and contracting frequency of the uterine smooth muscle, can inhibit the contraction of the uterine smooth muscle, can effectively treat dysmenorrheaand is promising in clinical application prospect.

Description

technical field [0001] The present invention relates to a new application of the total alkaloids of Chuanxiong, in particular to the application in the preparation of medicines for regulating uterine smooth muscle. Background technique [0002] Dysmenorrhea is one of the most common gynecological symptoms, which refers to lower abdominal pain, swelling, backache or other discomfort before and after menstruation or during menstruation. Dysmenorrhea is divided into two types: primary dysmenorrhea and secondary dysmenorrhea. The occurrence of primary dysmenorrhea is mainly related to the contraction of uterine smooth muscle. Excessive contraction of uterine smooth muscle will lead to vasospasm, resulting in uterine ischemia and hypoxic state and dysmenorrhea. [0003] Commonly used drugs for treating dysmenorrhea in Western medicine include: non-steroidal anti-inflammatory drugs, β-receptor agonists, and hormone drugs. They mainly relieve dysmenorrhea by reducing prostaglandins...

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Application Information

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IPC IPC(8): A61K36/236A61P15/06A61P15/00A61K125/00
CPCA61K36/236A61K2236/333A61K2236/53
Inventor 彭成熊亮刘娟蒲忠慧周勤梅
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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