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Regulation effect of TRPV1 on MAP addiction

A function and addiction technology, applied in the medical field, can solve the problems of addiction treatment dilemma and less research on MAP addiction mechanism.

Inactive Publication Date: 2018-11-13
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the relatively little research on the mechanism o

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  • Regulation effect of TRPV1 on MAP addiction
  • Regulation effect of TRPV1 on MAP addiction

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Embodiment Construction

[0010] The present invention will be described in detail below in combination with specific embodiments.

[0011] The use of TRPV1 antagonists and TRPV1 knockout mice has well documented that TRPV1 is involved in the regulation of MAP addiction and is achieved by altering presynaptic dopamine (dopamine, DA) release in key brain regions, a pathway that alters the cause of DA release is involved in the MAPK signaling pathway mediated through the DA receptor. In addition, TRPV1 also directly regulates MAP. The present invention utilizes optimized animal and cell models, adopts electrophysiological techniques and various molecular biological techniques to clarify its exact molecular mechanism, thereby providing reliable clues for the research on the treatment of addiction of MAP.

[0012] Experiment 1. Using intracerebral microinjection of TRPV1 antagonists to confirm that its regulatory effect on MAP addiction is specific to brain regions;

[0013] 1. Using C57BL / 6J male mice, ...

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Abstract

The invention discloses a regulation effect of TRPV1 on MAP addiction. TRPV1 directly regulates MAP or the TRPV1 regulates the MAP by changing the release of presynaptic dopamine DA in a key encephalic region. The TRPV1 has the advantages of being capable of guiding the treatment of MAP withdrawal, addiction and relapse.

Description

technical field [0001] The invention belongs to the field of medical technology, and relates to the regulating effect of TRPV1 on MAP addiction. Background technique [0002] The abuse and addiction of methamphetamine has become a serious public health problem and social problem. Since the 1990s, methamphetamine (Methamphetamine, MAP; methamphetamine) has become the fastest-growing and most widely abused central stimulant in the world. MAP not only has serious damage to the central nervous system of the human body, but also has extensive harm to drug addicts and their families from a sociological point of view. The 2015 China Drug Situation Report pointed out that by the end of 2015, new changes had taken place in the national drug abuse problem, showing that the proportion of people abusing heroin and other opioids decreased, while the proportion of people abusing synthetic drugs increased. Among the newly discovered 531,000 drug addicts, 80.5% abused synthetic drugs, of w...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P25/36
CPCA61K45/00A61P25/36
Inventor 田玉花郑劼金景玉
Owner QINGDAO UNIV