Application of Oxidized Precursin in Preparation of Drugs for Treating Postoperative Pain

A technology for oxidizing precursin and drugs, which is applied in the field of medicine, can solve the problems of low efficacy, tolerance and addiction, and large adverse reactions of therapeutic drugs, and achieve no sedative side effects, no tolerance, and relieve The effect of postoperative pain

Active Publication Date: 2020-04-28
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the deficiencies in the existing art of postoperative pain medicine (that is, the effectiveness of the treatment medicine is low, adverse reactions or tolerance and addiction, etc.), provides a kind of oxidized precursin Application in preparation of medicine for treating postoperative pain

Method used

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  • Application of Oxidized Precursin in Preparation of Drugs for Treating Postoperative Pain
  • Application of Oxidized Precursin in Preparation of Drugs for Treating Postoperative Pain
  • Application of Oxidized Precursin in Preparation of Drugs for Treating Postoperative Pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: The sedative effect experiment of oxidized precursin

[0025] Animal grouping: 50 male ICR mice; divided into 5 groups, namely normal control group and oxidized precursin 10mg / kg, 20mg / kg, 40mg / kg, 80mg / kg four dose groups, 10 in each group. The normal control group was given 0.5% carboxymethylcellulose sodium (CMC-Na), and all the other groups were intraperitoneally injected with oxidized prescurdin 10mg / kg, 20mg / kg, 40mg / kg, 80mg / kg (prepared with 0.5%CMC-Na). Suspension injection, administration volume is 10ml / kg), observe its spontaneous activity within 0.5h.

[0026] Autonomic activity test method refers to (Zhu Q, Mao LN, Liu CP, et al. Antinociceptive effects of vitexin in a mouse model of postoperative pain, Scientific Reports, 2016, 6: 19266), specifically: use the rat autonomic activity tester (YLS -1A, Jinan Yanyi Technology Co., Ltd., China), the instrument contains a control unit and 5 independent square black plastic dark boxes (12×15×15cm),...

Embodiment 2

[0028] Example 2: Effects of Acute Administration of Oxidized Precursin 5-40 mg / kg on the Mechanical Pain Threshold of Incision Pain Model Mice

[0029] Grouping of animals: 50 ICR mice, divided into 5 groups; the excipient group (given 0.5% CMC-Na); oxidized precursin 5, 10, 20, 40mg / kg four dose groups, 10 in each group (Note: subcutaneous injection is used, and oxidized procuredin is configured by 0.5% CMC-Na).

[0030] Firstly, the mice were adapted to the laboratory environment for 3 days, with alternating light and dark lighting for 12 hours, a temperature of 24±1°C, a humidity of 50-70%, and free access to water. Each mouse was individually placed in a plexiglass grid placed on a metal screen, and adapted to the environment until it was quiet. The basic mechanical pain paw withdrawal threshold (PWT) of each group of mice before surgery was measured using von Frey monofilament, and the continuous measurement was performed for 3 days. days to allow it to adapt to the int...

Embodiment 3

[0034] Example 3: Effects of chronic administration of 10-40 mg / kg oxidized precursin on the mechanical pain threshold of incision pain model mice

[0035] Grouping of animals: 40 ICR mice, divided into 4 groups; i.e. vehicle group (giving 0.5% CMC-Na); three dosage groups of oxidized precursin 10, 20, 40mg / kg, 10 in every group (note : Administered by subcutaneous injection, oxidized procuredin is configured by 0.5% CMC-Na). All mice in each group underwent incision surgery, and the operation method was the same as above. The pain threshold was measured 2 hours after operation, and then administered 24 hours after operation, once a day for 6 consecutive days. The pain threshold was measured every day before administration and 1.5h after administration, and the method for measuring the pain threshold was the same as before. see results image 3 and Figure 4 , image 3 It is the change of mechanical pain threshold of incision pain model mice after daily administration dur...

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Abstract

The invention relates to an application of oxypeucedanin in preparation of a drug for treating postoperative pain, which belongs to the technical field of medicine. According to the invention, oxypeucedanin is employed as a unique active component to prepare the drug for treating postoperative pain, in an incision postoperative ache model of mice foot, the oxypeucedanin presents excellent pain-easing effect while single administration, recovery of postoperative pain is promoted while repeated multitime administration, the drug has treatment effect, and has no obvious calmness side-effect and survivability generation. The drug is used with a hypodermic mode, and other administration modes can be employed. the incision postoperative ache model is employed, the acute single administrable amount is 5-40 mg / kg after model making, the chronic repeatedly-multitime administrable amount is 10-40 mg / kg per time after model making, and one time administration is provided each day.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of oxidized precursin in the preparation of medicine for treating postoperative pain. Background technique [0002] Postoperative pain is a complex physiological response of the body to the disease itself and tissue damage caused by surgery (Zhang Chuanhan. Guidelines for Clinical Pain Treatment [M]. Beijing: China Medical Science and Technology Press, 2008: 502). At present, the treatment of postoperative pain is still a thorny clinical problem. Although the pathological mechanism and treatment of postoperative pain have been studied in depth, and new analgesic drugs and technologies have been applied to clinics one after another, postoperative pain is still at a low level. Undertreatment status. According to reports, about 10%-50% of patients with postoperative pain are not effectively controlled, thus developing into chronic postoperative pain (Cl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/37A61P29/00
CPCA61K31/37A61P29/00
Inventor 朱清李俊旭卫蒨蒨潘菲邱男青李洁佳
Owner NANTONG UNIVERSITY
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