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The New Application of Oxidized Precursin

A technology for oxidized prehulin and uses, applied in the field of medicine, can solve the problems of large adverse reactions, low efficacy, tolerance, etc., and achieves no sedative side effects, no tolerance, and alleviation of chronic neuropathic pain and inflammation. Effects of sexual pain

Active Publication Date: 2020-05-08
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problems of low effectiveness, large adverse reactions or tolerance and addiction of current chronic pain treatment drugs, the present invention provides a new use of oxidized precursin as the only active ingredient in the preparation of chronic pain drugs

Method used

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  • The New Application of Oxidized Precursin
  • The New Application of Oxidized Precursin
  • The New Application of Oxidized Precursin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: The sedative effect experiment of oxidized precursin

[0023] Grouping of animals: 50 male ICR mice; divided into 5 groups, ie normal control group and four dose groups of oxidized precursin, 10 in each group. The normal control group was given excipient 0.5% carboxymethyl cellulose sodium (CMC-Na), and all the other groups were intraperitoneally injected oxidized precursin 10mg / kg, 20mg / kg, 40mg / kg, 80mg / kg (with 0.5%CMC -Na was made into a suspension injection, and the volume of administration was 10ml / kg), and its spontaneous activity was observed within 0.5h.

[0024]Autonomic activity test method refers to (Zhu Q, Mao LN, Liu CP, et al. Antinociceptive effects of vitexin in a mouse model of postoperative pain, Scientific Reports, 2016, 6:19266), specifically: use a tester for autonomic activity in rats and mice (YLS-1A, Jinan Yanyi Science and Technology Co., Ltd., China), the instrument contains a control unit and 5 independent square black plastic ...

Embodiment 2

[0026] Example 2: Analgesic effect of acute administration of oxidized precursin on mouse CCI neuropathic pain model

[0027] (1) Preparation method of CCI neuropathic pain mouse model: refer to literature (Zhao X, et al. 843-854), the mice were anesthetized with isoflurane, and the right sciatic nerve was surgically exposed. At the main part of the nerve, 4.0 chrome catgut was loosely ligated in 3 lanes, and the interval between each catgut was 1mm, and the muscles were sutured layer by layer. After surgery, the rats were fed in a quiet, warm environment, avoiding strong light. The mechanical paw withdrawal threshold (PWT) of the mice was measured by the von Frey monofilament method 2 hours after the CCI operation and every 24 hours thereafter.

[0028] Determination method of von Frey monofilament: use 7 kinds of strength Von-Frey filaments, increase the bending strength according to approximately logarithm (equivalent to 0.07, 0.16, 0.4, 0.6, 1.0, 1.4, 2.0g), from 0.07g A...

Embodiment 3

[0031] Example 3: Analgesic effect of chronic administration of oxidized precursin on mouse CCI neuropathic pain model

[0032] Grouping of animals: 40 ICR mice, divided into 4 groups; i.e. vehicle group (giving 0.5% CMC-Na); three dosage groups of oxidized precursin 10, 20, 40mg / kg, 10 in every group (note : Administered by intraperitoneal injection, oxidized proscurdin is prepared by 0.5% CMC-Na). All the mice in each group underwent CCI operation, and the operation method was the same as above. The pain threshold was measured 2 hours after the operation, and then administered 24 hours after the operation, administered once a day for 7 consecutive days, the first day of administration was recorded as d1, and so on, that is, the 7 days of administration were recorded as d1 ~d7. The pain threshold was measured every day before the administration (denoted as 0h) and 2h after the administration, and the method for measuring the pain threshold was the same as before.

[0033] ...

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Abstract

The invention relates to new application of oxypeucedanin to preparation of drugs for treating chronic pain by serving as the only active component, and belongs to the technical field of medicine. A mouse chronic constriction injury model and a complete Freund's adjuvant causing metapodium inflammatory pain model are built, the models present chronic neuropathic pain and inflammatory pain, oxypeucedanin is feed to conduct the treatment after modeling, oxypeucedanin is feed through intraperitoneal injection, the drug feeding dose is 10-40mg / kg, and it is proved that oxypeucedanin has the good abirritation effect on chronic neuropathic pain and inflammatory pain by being feed in singe-dose or repeatedly feed once a day, no sedation effect is caused, and no adverse reactions such as toleranceand addiction occurs if oxypeucedanin is feed for a long time, and it is reminded that oxypeucedanin can be applied to drug therapy of various kinds of chronic pain, in particular to neuropathic painand inflammatory pain.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a new application of oxidized prescurdin. Background technique [0002] Chronic pain refers to a physiological response to tissue damage, disease-related or spontaneous pain that persists or recurs for more than 12 weeks or exceeds the time required for tissue healing (Rajapakse D, Liossi C, Howard RF. Presentation and management of chronic pain) pain[J].Arch Dis Child,2014,99(5):474-480.). According to the American Medical Research Report, about 30% of the population in the United States experience chronic pain, which exceeds the sum of patients with heart disease, cancer, and diabetes. In my country, according to local epidemiological reports, the incidence of chronic pain in Chaoyang District of Beijing is 53.0%. In addition, according to statistics from the National Cancer Registry Center, in 2015, there were 4.29 million new cancer cases in China and 2.81 mill...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/37A61P29/00A61P25/04A61P25/24A61P25/08
CPCA61K31/37A61P25/04A61P25/08A61P25/24A61P29/00
Inventor 朱清卫蒨蒨唐文婷李俊旭潘菲邱男青周致用李洁佳
Owner NANTONG UNIVERSITY
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