Application of sinomenine in the preparation of drugs for the treatment of chronic pain accompanied by depressive behavior

A technology of chronic pain and sinomenine, which is applied in the field of medicine, can solve the problems of low effectiveness, large adverse reactions, and addiction, and achieve the effect of alleviating pain, no sedative side effects, and reducing and improving depression-like behaviors
CN104257658BActive Publication Date: 2017-01-04苏州康纯医药科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
苏州康纯医药科技有限公司
Publication Date
2017-01-04

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Abstract

The invention relates to a new medical application of sinomenine. The invention provides the application of sinomenine as the sole active ingredient in the preparation of a medicine for treating chronic pain accompanied by depression behavior. The present invention uses a rat model of sciatic nerve compression injury, which manifests as chronic neurogenic pain and induces depressive behavior, and confirms that sinomenine has a good analgesic effect on chronic pain, and can improve its depressive-like behavior without tolerance Adverse reactions such as acceptability and sedative effect.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to the application of sinomenine in the preparation of medicines for treating chronic pain with depression-like behavior. Background technique

[0002] Chronic pain refers to the pain due to tissue damage, disease-related or spontaneous pain that persists or recurs for more than 12 weeks or exceeds the time required for tissue healing (Rajapakse D, Liossi C, Howard RF. Presentation and management of chronic pain, [J] . Arch Dis Child, 2014, 99(5): 474-480.). Clinically, chronic pain is a problem that is often overlooked, but it brings continuous and great pain to patients. It has been found in long-term clinical practice that chronic pain is often accompanied by depressive behavior, so some scholars call it pain-depression syndrome. Clinical studies have shown that chronic pain patients are much more likely to develop depression than pain-free patients (Taloyan M, Lofvander M. De...

Claims

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