A kind of color-preserving fixative for anatomy teaching specimen and preparation method thereof

A color fixation and specimen technology, applied in the field of specimen fixatives, can solve the problems of irritant, toxic, flammable and explosive, affecting the fidelity of specimens, and discoloring specimens, achieving remarkable environmental protection properties, and improving production quality and production efficiency. , the effect of long color retention time

Active Publication Date: 2021-08-27
山东聚众数字医学科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

That is to say: Most of these traditional fixative components have use defects such as irritation, toxicity, volatility, flammability and explosiveness.
At the same time, during the soaking and use of the existing fixatives for animal specimens, there are various degrees of fading and dimming of the specimens.
Namely: when the animal soaked specimen is soaked in the fixative for a long time, the appearance of the animal tissue will fade to varying degrees due to bacterial invasion, colony reproduction, cell oxidation and other reasons, which will affect the fidelity of the specimen

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] A method for preparing a color-preserving fixative for an anatomy teaching specimen, comprising the following steps:

[0027] (1) Preparation of citrus fruit peel extract

[0028]Take the peel of the citrus fruit, wash and dry it, put it in a crusher and break it into a slurry, and then add 0.3-0.7% of its mass cellulase and 0.2-0.4% of its mass to the slurry. Glue enzyme, after stirring evenly, carry out enzymolysis treatment at 40-50°C for 1.5-2.5h. During the enzymolysis treatment, perform ultrasonic treatment for 20-30S every 30min, and then, under constant stirring, Add NaOH solution to the obtained enzymatic hydrolysis product until the pH of the obtained mixture is 10-11, then carry out vacuum filtration, take the filtrate, and under the condition of constant stirring, assist in the ultrasonic vibration treatment with a frequency of 55-65KHz, add to the filtrate Add an acid-base regulator acetic acid solution or phosphoric acid solution to adjust the pH of the f...

Embodiment 1

[0037] A color-preserving fixative for anatomy teaching specimens, consisting of the following components in parts by weight: 2.5 parts of sodium lauryl sulfate, 12 parts of urea, 0.5 parts of potassium sorbate, 0.3 parts of citric acid, and 1,2-propylene glycol 20 parts, 0.6 parts of sodium tripolyphosphate, 0.5 parts of ascorbic acid, 0.2 parts of L-cysteine, 1 part of citrus fruit peel extract, 1.2 parts of tea residue extract, 65 parts of distilled water.

[0038] A method for preparing a color-preserving fixative for an anatomy teaching specimen, comprising the following steps:

[0039] (1) Preparation of citrus fruit peel extract

[0040] Get the pericarp of citrus fruit, wash and dry, place in a crusher and break into a slurry, after that, add 0.6% of its mass of cellulase and 0.3% of its mass of pectinase to the slurry, stir After uniformity, carry out enzymolysis treatment at 45°C for 2 hours. During the enzymolysis treatment, perform ultrasonic treatment for 25 seco...

Embodiment 2

[0048] A color-preserving fixative for anatomy teaching specimens, consisting of the following components in parts by weight: 2 parts of sodium lauryl sulfate, 15 parts of urea, 0.3 parts of potassium sorbate, 0.2 parts of citric acid, and 1,2-propylene glycol 18 parts, 0.7 parts of sodium tripolyphosphate, 0.4 parts of ascorbic acid, 0.1 parts of L-cysteine, 1.3 parts of citrus fruit peel extract, 1 part of tea residue extract, 60 parts of distilled water.

[0049] A method for preparing a color-preserving fixative for an anatomy teaching specimen, comprising the following steps:

[0050] (1) Preparation of citrus fruit peel extract

[0051] Get the pericarp of citrus fruits, wash and dry, place in a crusher and break into a slurry, after that, add 0.7% of its mass of cellulase and 0.2% of its mass of pectinase to the slurry, stir After uniformity, carry out enzymolysis treatment at 40°C for 2.5 hours. During the enzymolysis treatment, perform ultrasonic treatment for 30 sec...

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Abstract

A color-preserving fixative for anatomy teaching specimens, consisting of the following components in parts by weight: 2-3 parts of sodium lauryl sulfate, 10-15 parts of urea, 0.3-0.7 parts of potassium sorbate, and 0.2-0.2 parts of citric acid 0.5 parts, 1,2-propylene glycol 18-23 parts, sodium tripolyphosphate 0.5-0.7 parts, ascorbic acid 0.4-0.6 parts, L-cysteine ​​0.1-0.3 parts, citrus fruit peel extract 0.8-1.3 parts, 1-1.5 parts of tea residue extract, 60-67 parts of distilled water. A color-preserving fixative for anatomy teaching specimens and a preparation method thereof of the present invention can quickly infiltrate and fill animal specimen cells, and have good antibacterial and sterilizing effects, prevent mildew, and maintain color and resist oxidation. Improve the fixation quality, effect, storage time and color of animal soaked specimens. At the same time, the components of the fixative are safe, non-toxic and environmentally friendly.

Description

technical field [0001] The invention belongs to the technical field of specimen fixatives, in particular to a color-preserving fixative for anatomy teaching specimens and a preparation method thereof. Background technique [0002] There are many kinds and varieties of animal teaching specimens, mainly including soaked specimens, plasticized specimens, peeled specimens, transparent specimens, bone specimens, dried specimens, pathological tissue specimens, etc., which play an important role in scientific research, teaching and popular science. effect. Among them, soaked specimens have the longest application history and wide range because of their simple preparation method and easy operation. The preparation steps of soaked specimens include peeling, removing fat, residual meat, connective tissue, contaminated blood, etc., followed by cleaning, degreasing, tanning, neutralization, cleaning, and then fixing in fixative solution. [0003] Traditional fixatives used for fixatio...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): G01N1/28
CPCG01N1/28
Inventor郑彬龙王广欣郭均兵张学森
Owner山东聚众数字医学科技开发有限公司