Method for the detection of imidazolines in biological fluids for criminal investigation purposes

A biological fluid and medium imidazoline technology, which is applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of few imidazoline drugs, no reports of drug testing, and inability to meet the needs of actual case testing.
CN108956795BActive Publication Date: 2021-08-06INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
Publication Date
2021-08-06

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Abstract

The invention discloses a method for detecting imidazoline drugs in biological fluids for the purpose of criminal investigation, comprising the following steps: biological fluid pretreatment; extraction and detection of imidazoline drugs in biological fluids. Established pretreatment formulations and liquid chromatography-mass spectrometry analysis methods for five common imidazoline drugs in biological fluids, tetrahydrozoline, xylometazoline, naphazoline, antazoline, and oxymetazoline. The average recovery The rate is more than 70%, and the detection limit is less than 1ng / mL.
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Description

technical field

[0001] The invention relates to the field of forensic toxicology analysis. More specifically, it relates to a method for detecting imidazoline drugs in biological fluids. Background technique

[0002] There are few studies on the analysis of imidazoline drugs. There are only domestic studies on the detection of the active ingredients of imidazoline drugs in drugs, and there are no reports on the detection of such drugs in biological fluids; foreign research is also mainly focused on drug quality control. Although the analysis and research of imidazoline drugs in biological samples has been involved, the existing methods are far from meeting the needs of actual case testing. SUMMARY OF THE INVENTION

[0003] An object of the present invention is to provide a method for extracting and detecting imidazoline drugs in biological fluids with good repeatability, high sensitivity and easy operation.

[0004] In order to achieve the above object, the present inven...

Claims

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