Method for the detection of imidazolines in biological fluids for criminal investigation purposes

A biological fluid and medium imidazoline technology, which is applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of few imidazoline drugs, no reports of drug testing, and inability to meet the needs of actual case testing.

Active Publication Date: 2021-08-06
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] There are few studies on the analysis of imidazoline drugs. There are only domestic studies on the detection of the active ingredients of imidazoline drugs in drugs, and there are no reports on the detection of such drugs in biological fluids; foreign research is also mainly focused on drug quality control. Although the analysis and research of imidazoline drugs in biological samples has been involved, the existing methods are far from meeting the needs of actual case inspections

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  • Method for the detection of imidazolines in biological fluids for criminal investigation purposes
  • Method for the detection of imidazolines in biological fluids for criminal investigation purposes
  • Method for the detection of imidazolines in biological fluids for criminal investigation purposes

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Embodiment Construction

[0025] In order to illustrate the present invention more clearly, the present invention will be further described below in conjunction with preferred embodiments and accompanying drawings. Similar parts in the figures are denoted by the same reference numerals. Those skilled in the art should understand that the content specifically described below is illustrative rather than restrictive, and should not limit the protection scope of the present invention.

[0026] The first part is the detection of tetrahydrozoline, xylometazoline, naphazoline, antazoline and oxymetazoline in biological fluids method

[0027] 1. Experimental method

[0028] 1.1 Reagents, materials and instruments

[0029] 1.1.1 Reagents and materials: tetrahydrozoline, xylometazoline, naphazoline, oxymetazoline, and antazoline were all purchased from the United States Pharmacopoeia (USP), with a purity of 99.9%; methanol, acetonitrile, formic acid, Ammonium formate, ammonium acetate (chromatographically...

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Abstract

The invention discloses a method for detecting imidazoline drugs in biological fluids for the purpose of criminal investigation, comprising the following steps: biological fluid pretreatment; extraction and detection of imidazoline drugs in biological fluids. Established pretreatment formulations and liquid chromatography-mass spectrometry analysis methods for five common imidazoline drugs in biological fluids, tetrahydrozoline, xylometazoline, naphazoline, antazoline, and oxymetazoline. The average recovery The rate is more than 70%, and the detection limit is less than 1ng / mL.

Description

technical field [0001] The invention relates to the field of forensic toxicology analysis. More specifically, it relates to a method for detecting imidazoline drugs in biological fluids. Background technique [0002] There are few studies on the analysis of imidazoline drugs. There are only domestic studies on the detection of the active ingredients of imidazoline drugs in drugs, and there are no reports on the detection of such drugs in biological fluids; foreign research is also mainly focused on drug quality control. Although the analysis and research of imidazoline drugs in biological samples has been involved, the existing methods are far from meeting the needs of actual case testing. SUMMARY OF THE INVENTION [0003] An object of the present invention is to provide a method for extracting and detecting imidazoline drugs in biological fluids with good repeatability, high sensitivity and easy operation. [0004] In order to achieve the above object, the present inven...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/062
Inventor 任昕昕崔冠峰王爱华王瑞花宋歌张云峰常靖黄健董林沛于忠山王芳琳董颖侯小平魏春明栾玉静杜鸿雁张蕾萍
Owner INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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