A kind of haloamine antimicrobial agent containing double active groups and its preparation method and application

A technology with double active groups and double active groups, which is applied in disinfectants, textiles and papermaking, chemicals for biological control, etc., can solve the toxic and side effects of organic antibacterial agents, poor washability of inorganic antibacterial agents, and natural antibacterial agents Extraction difficulties and other problems, to achieve the effect of low price, saving consumption and high efficiency

Active Publication Date: 2020-05-05
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most antibacterial agents have their disadvantages. Inorganic antibacterial agents have poor washability and slow sterilization rate; natural antibacterial agents are difficult to extract; most organic antibacterial agents have toxic side effects and are harmful to the human body.

Method used

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  • A kind of haloamine antimicrobial agent containing double active groups and its preparation method and application
  • A kind of haloamine antimicrobial agent containing double active groups and its preparation method and application
  • A kind of haloamine antimicrobial agent containing double active groups and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] refer to figure 1 , a kind of haloamine antimicrobial agent containing two active groups, its preparation method comprises the steps:

[0038] (1) Weigh 2.34g of 2-chloroethylamine hydrochloride, 1.66g of sodium hydroxide and 2.61g of 5,5-dimethylhydantoin to react in ethanol for 12h, filter to remove sodium chloride after completion, and distill under reduced pressure , dried to obtain amine ethyl hydantoin;

[0039] (3) Take by weighing 3.64g of cyanuric chloride, dissolve it in 25mL of acetone, take by weighing 5.64g of p-(sodium β-ethylsulfone sulfate) aniline and 1.06g of sodium carbonate, dissolve it in 20mL of water, and mix the two Mix them with a 250mL three-necked flask, and react for 2 hours at 0~5°C under the condition of pH 2.5~3.5, then dissolve 25mL of aminoethyl hydantoin obtained above in 25mL of water and pour it into the reaction solution, and heat up to 40 °C, react for 4 hours under the condition that the pH value is 5.0-6.0, add 20% sodium chlori...

Embodiment 2

[0041] refer to figure 1 , a kind of haloamine antimicrobial agent containing two active groups, its preparation method comprises the steps:

[0042] (1) Reflux 2.61g of 5,5-dimethylhydantoin and 0.83g of sodium hydroxide in ethanol for 10min, join in the ethanol solution of 2.34g of 2-chloroethylamine hydrochloride and 1.06g of sodium carbonate powder, react 14h, then remove sodium chloride by suction filtration, distill under reduced pressure and dry to obtain aminoethylhydantoin;

[0043] (2) Weigh 3.64g of cyanuric chloride, add it into 25mL of water and stir, dissolve the aminoethyl hydantoin obtained above in 25mL of water and add dropwise to the cyanuric chloride suspension. After reacting in an ice bath for 3 hours, add 5.64 g of p-(β-ethylsulfone sodium sulfate) aniline and 1.06 g of sodium carbonate in water, react at 40°C for 2 hours, adjust the pH at 5-7 throughout the whole process, and add 20% of Sodium chloride solid (to the weight of the reaction solution) is...

Embodiment 3

[0045] A kind of antibacterial agent precursor, its preparation method comprises the steps:

[0046](1) Weigh 3.64g of cyanuric chloride, 5.64g of p-(β-ethylsulfone sodium sulfate) aniline and 1.06g of sodium carbonate into 50mL of water, react for 5h, adjust the pH to 2.5-3.5, and filter with ethanol and Methanol cleaning, drying;

[0047] (2) Reflux 2.61g of 5,5-dimethylhydantoin and 0.83g of sodium hydroxide in ethanol for 10min, join in the ethanol solution of 2.34g of 2-chloroethylamine hydrochloride and 1.06g of sodium carbonate powder, react After 16 hours, add the aqueous solution of the solid obtained in the previous step, adjust the pH to 5-6, react for 4 hours, filter with suction after the end, wash with ethanol, dry, and store to obtain the antibacterial agent precursor.

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Abstract

The invention discloses a halamine antibacterial agent containing double active groups. A structure of the antibacterial agent is as shown in a general formula (1), in the general formula (1), R1 andR2 represent Cl or Br separately and independently, 5,5-dimethylhydantoin, 2-chloroethylaminehydrochloride and alkali are reacted to prepare aminoethyl hydantoin, then the aminoethyl hydantoin, p-(beta-sulfato ethyl sulfonyl)anilin, cyanuric chloride and the like are reacted to prepare a halamine antibacterial precursor, and finally, after the halamine antibacterial precursor is treated through asodium hypochlorite solution, the halamine antibacterial agent is prepared. A production method of the antibacterial agent is simple, raw material prices are low, product purification is simple and convenient, a finishing step is simple, and a finished product has good antibacterial property and stability.

Description

technical field [0001] The invention relates to the field of antibacterial technology, in particular to a haloamine antibacterial agent containing dual active groups, a preparation method and application thereof. Background technique [0002] With the significant improvement of people's living standards and the rapid development of industry in our country, people's awareness of health, safety and environmental hygiene is increasing, and antibacterial is becoming more and more important in many fields. Cotton is currently the most commonly used natural fiber, because of its good performance, it is widely used in clothing, home textiles and other occasions that are in close contact with the human body. However, the good hygroscopicity of cotton fiber and the sugars contained in the fiber provide energy for the reproduction of microorganisms under certain conditions (including humidity and temperature), so that they can grow and reproduce rapidly. This will cause harm to human...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D403/12A01P1/00D06M13/432D06M101/06
CPCC07D403/12D06M13/432D06M16/00D06M2101/06
Inventor 任学宏穆童刘颖李蓉栗志广
Owner JIANGNAN UNIV
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