A kind of reactive halamine antibacterial agent and its preparation method and application

Abstract

The invention discloses a reaction type halamine antiseptic. The structural formula of the antiseptic is represented in the description. In the structural formula, the R represents F or Cl, and the R1 and R2 individually represent Cl or Br. The preparation method comprises the following steps: (1) in an alkaline condition, reacting 5,5-dimethylhydantoin with 3-chloro-1-propanol to generate 3-hydroxypropyl-5,5-dimethylhydantoin; (2) carrying out one-step reaction between sodium sulfanilate and 3-hydroxypropyl-5,5-dimethylhydantoin to obtain a halamine antiseptic precursor (II); (3) reacting the halamine antiseptic precursor (II) with sodium hypochlorite so as to obtain the finished product of halamine antiseptic. The chlorine content of the textile processed by the antiseptic can reach 0.35%, the sterilizing rate on staphylococcus aureus can reach 100% in 10 minutes, and the sterilizing rate on escherichia coli O157:H7 can reach 100% within one minute. The operation is simple during the whole synthesis process, no toxic byproduct is generated, and the synthesis raw materials are cheap.

Description

technical field [0001] The invention belongs to the field of antibacterial technology, and in particular relates to a reactive haloamine antibacterial agent and its preparation method and application. Background technique [0002] In recent years, with the improvement of people's living standards, antibacterial has become more and more important in many fields. In textiles, cotton fiber is widely liked by people for its good performance, but the good hygroscopicity of cotton fiber and the sugars contained in the fiber provide energy for microbial reproduction under certain conditions, and under certain conditions (including humidity, temperature, etc.) etc.), microorganisms can grow and reproduce rapidly. This not only affects the wearing performance of the fabric itself, but also endangers human health. Therefore, the antibacterial finishing of cotton fabrics is particularly important, and has received extensive attention from researchers. Many different types of antibact...

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Problems solved by technology

[0004] Cotton fibers contain many active hydroxyl groups, which can react with some reactive substances, which points out the direction for the selection and application of antibacterial agents. The patent application number 201210293286.8 "A haloamine antibacterial agent and its Preparation method and application" and the patent of application number 201310475978.9 "A reactive haloamine antibacterial agent and its synthesis method and application" by combining the haloamine antibacterial carrier 2,2,6,6-tetramethylpiperidinol with three Polycyanuric fluoride or cyanuric chloride reacts to generate dichloride and a chloro-s-triazine halide antibacterial agent precursor, and the two are grafted onto cotton fabrics. After chlorination, the fabric has certain antibacterial properties and regeneration properties, and It has little effect on the physical and mechanical properties of cotton fabrics; but these two compounds have antibacterial properties through the chlorination of amino groups, and their effects are not as good as amides or imides, and the patented synthetic antibacterial agent precursor with application number 201210293286.8 The water solubility is not good, and its washing and regeneration performance is not very good, which affects its application

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