Application of genistein in aspect of reducing N-glycolylneuraminic acid in deuterostome body

A technology of genistein and neuraminic acid, applied in the field of genistein reducing N-glycolylneuraminic acid in deuterostomes, can solve the problems of no relevant reports, reduction of superoxide production, etc., and achieve food quality and No effect on nutritional value

Active Publication Date: 2018-12-18
GUIZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this anti-tumor effect is mainly based on the fact that the tumor has already occurred, and it exerts an anti-tumor effect by inducing the apoptosis of T lymphoma cells, breast cancer, prostate cancer and colon cancer cells; in addition, it has been reported in the literature that genistein acts as Tyrosine protein kinase inhibitors inhibit tyrosine phosphorylation-dependent small G protein Rac membrane translocation, further inhibit the activity of intracellular reduced coenzyme II (NADPH) oxidase, and reduce the production of superoxide in cells, thereby Reach the effect of anti-oxidation, but there is no relevant report on the effect on the biosynthesis of Neu5Gc

Method used

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  • Application of genistein in aspect of reducing N-glycolylneuraminic acid in deuterostome body
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  • Application of genistein in aspect of reducing N-glycolylneuraminic acid in deuterostome body

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Experimental program
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Embodiment Construction

[0014] Animal Feeding:

[0015] Select 80 SPF grade male SD rats at the age of 30 days, and after one week of adaptive feeding, they were randomly divided into two groups: solvent control group (blank control group), genistein group (experimental group), 40 in each group; The temperature of the room is controlled at 23±2°C, the humidity is 60%, and the day and night are alternated for 12 hours; free to eat and drink. The blank group and the experimental group were given 5% ethanol solution and 300mg / kg.d genistein solution by oral gavage respectively.

[0016] Sample Collection:

[0017] After continuous gavage for 15 days, 30 days, 45 days, and 60 days, after the rats in each group could not help water or food, samples of hind legs, kidneys, and livers were taken from 10 rats in the blank control group and the experimental group respectively. Store at -80°C until use.

[0018] Specific methods for sample testing:

[0019] High performance liquid chromatography conditions ...

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Abstract

The invention discloses application of genistein in an aspect of reducing N-glycolylneuraminic acid in a deuterostome body, and belongs to the technical field of biochemistry. Experiments prove that the genistein can restrain biosynthesis of Neu5Gc in the animal body, is safe without toxic and side effects, and does not affect the edible quality and nutrition values of meat.

Description

technical field [0001] The invention belongs to the technical field of biochemistry, and specifically relates to the use of genistein in reducing N-glycolylneuraminic acid in deuterostomes. Background technique [0002] A large number of epidemiological data show that excessive intake of red meat and processed meat is closely related to the occurrence of cancer. Red meat may be one of the causes of some tumors. Sufficient epidemiological evidence shows that red meat and processed meat are one of the factors that cause colon / rectal cancer; red meat is one of the causes of esophageal cancer, lung cancer, pancreatic cancer and endometrial cancer; One of the causes of esophageal cancer, lung cancer, stomach cancer and prostate cancer. Eating too much red and processed meat increases the risk of lung and colorectal cancer by 20 percent and bowel cancer by 30 percent. The high-risk carcinogenic substance in red meat is immunogenic N-glycolylneuraminic acid (Neu5Gc). Neu5Gc in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P43/00
CPCA61P43/00A61K31/352
Inventor 朱秋劲李洪英常瑞徐阿奇周樱子晏印雪
Owner GUIZHOU UNIV
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