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Application of membrane separation technology in preparation process of wine-fried Ligustri Lucidi Fructus and Yerbadetajo Herb immunity-enhancing oral liquid

A preparation process, a technology for oral liquids, applied in the directions of dispersion liquid delivery, medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, etc. The effect of optimizing the impurity removal process and saving production costs

Inactive Publication Date: 2018-12-18
河北普德动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of Zhenlian Zengfang Oral Liquid adopts the traditional process of water extraction, alcohol precipitation and impurity removal, which is complicated and relatively high in cost

Method used

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  • Application of membrane separation technology in preparation process of wine-fried Ligustri Lucidi Fructus and Yerbadetajo Herb immunity-enhancing oral liquid
  • Application of membrane separation technology in preparation process of wine-fried Ligustri Lucidi Fructus and Yerbadetajo Herb immunity-enhancing oral liquid
  • Application of membrane separation technology in preparation process of wine-fried Ligustri Lucidi Fructus and Yerbadetajo Herb immunity-enhancing oral liquid

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Experimental program
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Effect test

preparation example Construction

[0018] 1) Preparation of Zhenlian Zengjian Water Extract

[0019] Add water to decoct Ligustrum lucidum, Eclipta, Epimedium, Astragalus, Arctium and Gynostemma 3 times, each time for 1 hour, and combine the filtrates to obtain the water extract of Ligustrum lucidum; The amount is 8 to 12 times the total mass of Ligustrum lucidum, Eclipta, Epimedium, Astragalus, Arctium and Gynostemma;

[0020] 2) Preparation of Zhenlian Zengjian Oral Liquid

[0021] Place the Zhenlian Zengfang water extract obtained in step 1) in the feed cylinder of the membrane separation device, perform microfiltration and / or ultrafiltration in a cross-flow manner sequentially to obtain a filtrate, and concentrate the filtrate to obtain a concentrate, Add mass concentration to the concentrated solution and be 3‰ sodium benzoate, stir evenly and fill, to get final product; the membrane that microfiltration adopts is microfiltration membrane, and the membrane that ultrafiltration adopts is ultrafiltration me...

Embodiment 1

[0029] 1) Preparation of Zhenlian Zengjian Water Extract

[0030] Add water to decoct 120g Ligustrum lucidum, 150g Eclipta, 100g Epimedium, 16g Astragalus, 20g Burdock, and 35g Jiaogulan 3 times, each time for 1h, and combine the filtrates to obtain the water extract of Zhenlian. When decocting, the amount of water added is 8 to 12 times the total mass of Ligustrum lucidum, Eclipta, Epimedium, Astragalus, Burdock, and Gynostemma;

[0031] 2) Preparation of Zhenlian Zengjian Oral Liquid

[0032] The Zhenlian Zengfang water extract obtained in step 1) is placed in the feed cylinder of the membrane separation equipment, and microfiltration and ultrafiltration are carried out in a cross-flow manner successively to obtain the filtrate, and the filtrate is concentrated to obtain a concentrated solution, which is sent to the concentrated Add mass concentration in the liquid and be 3 ‰ sodium benzoate, stir evenly and fill, to obtain final product; The membrane that microfiltration a...

Embodiment 2

[0035] 1) Preparation of Zhenlian Zengjian Water Extract

[0036] Add water to decoct 150g Ligustrum lucidum, 160g Eclipta chinensis, 130g Epimedium, 18g Astragalus, 30g Burdock, and 45g Jiaogulan 3 times, each time for 1h, and combine the filtrates to obtain the water extract of Zhenlian Zengjian; each time When decocting, the amount of water added is 8 to 12 times the total mass of Ligustrum lucidum, Eclipta, Epimedium, Astragalus, Burdock, and Gynostemma;

[0037] 2) Preparation of Zhenlian Zengjian Oral Liquid

[0038] The Zhenlian Zengfang water extract obtained in step 1) is placed in the feed cylinder of the membrane separation equipment, and microfiltration and ultrafiltration are carried out in a cross-flow manner successively to obtain the filtrate, and the filtrate is concentrated to obtain a concentrated solution, which is sent to the concentrated Add mass concentration in the liquid and be 3 ‰ sodium benzoate, stir evenly and fill, to obtain final product; The me...

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Abstract

The invention discloses an application of a membrane separation technology in the preparation process of a wine-fried Ligustri Lucidi Fructus and Yerbadetajo Herb immunity-enhancing oral liquid. The membrane separation technology is applied to the preparation process of the wine-fried Ligustri Lucidi Fructus and Yerbadetajo Herb immunity-enhancing oral liquid, immunity-enhancing water extract of wine-fried Ligustri Lucidi Fructus and Yerbadetajo Herb undergoes membrane filtration impurity removal and membrane concentrating in a manner of combining microfiltration, ultrafiltration and nanofiltration by using the principle of intercepting different molecular weights by using different membrane modules, and the optimization of the impurity removal process ensures the stability of the oral liquid; and compared with traditional water extraction and alcohol precipitation technologies, the technology in the invention provides a reference for the applicability of the technology applied to theimpurity removal process of the immunity-enhancing water extract of Wine-fried Ligustri Lucidi Fructus and Yerbadetajo Herb. Experimental results show that the transfer rates of Specnuezhenide and icariin in the wine-fried Ligustri Lucidi Fructus and Yerbadetajo Herb immunity-enhancing oral liquid prepared by the membrane separation technology is 70% or above, the Specnuezhenide content and the icariin content of the prepared the wine-fried Ligustri Lucidi Fructus and Yerbadetajo Herb immunity-enhancing oral liquid are higher than those of extract prepared by the traditional alcohol precipitation technologies, and the production cost is saved, so the traditional water extraction and alcohol precipitation technologies can be replaced.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to the field of preparation technology of Zhenlian Zengjian Oral Liquid, in particular to the application of a membrane separation technology in the preparation technology of Zhenlian Zengjian Oral Liquid. Background technique [0002] With the continuous development and intensification of the poultry breeding industry, the growth environment of poultry and livestock has been continuously improved, and the production performance has been maximized. At the same time, activities have been restricted. Self-regulation function declines, resistance is poor, and many factors in breeding management, such as weather changes, water and electricity cuts, replacement of breeders, vaccine immunization, etc., may become the cause of its disease. In order to prevent and control diseases, the traditional method is to use a large amount of antibiotics. As a result, the number of drug-resistant stra...

Claims

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Application Information

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IPC IPC(8): A61K36/638A61K9/08A61P37/04
CPCA61K9/0095A61K36/28A61K36/296A61K36/424A61K36/481A61K36/638A61K2236/331A61K2236/53A61P37/04A61K2300/00
Inventor 陆安杜红娜刘炳伟贾永兵郭永国郭永红
Owner 河北普德动物药业有限公司
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