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A biomimetic multifunctional nano-preparation based on cancer cell membrane and its preparation method and application

A cancer cell membrane and nano-preparation technology, applied in the field of medicine, to achieve good biocompatibility, improve therapeutic effect, and avoid the effect of phagocytosis

Active Publication Date: 2021-05-14
上海揽微赛尔生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, achieving rapid release of membrane-loaded drugs remains a challenge

Method used

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  • A biomimetic multifunctional nano-preparation based on cancer cell membrane and its preparation method and application
  • A biomimetic multifunctional nano-preparation based on cancer cell membrane and its preparation method and application
  • A biomimetic multifunctional nano-preparation based on cancer cell membrane and its preparation method and application

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Embodiment Construction

[0035] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0036] Doxorubicin hydrochloride and indocyanine green were purchased from Dalian Meilun Biotechnology Co., Ltd., and cell membrane protein and cytoplasmic protein extraction kits were purchased from Beyond Biotechnology Co., Ltd.

[0037] (1) Dehydrochlorination treatment of doxorubicin hydrochloride: Weigh 5mg of doxorubicin hydrochloride and add it to a 10mL sample bottle for dark treatment, add 4.5mL dimethyl sulfoxide (DMSO) solution to fully dissolve doxorubicin hydrochloride, and magnetically stir Under the condition (600rpm, 37°C), 0.5mL triethylamine was added and reacted overnight. The resulting product is desalted doxorubicin.

[0038] (2) Preparation of nanoparticle core...

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Abstract

The invention discloses a biomimetic multifunctional nano-preparation based on cancer cell membrane and its preparation method and application. Cervical cancer cell membranes form a shell structure. During preparation, a nanoparticle core self-assembled by two anticancer drugs (DOX, ICG) was prepared first, and then the outer layer was wrapped with human cervical cancer cell membranes for bionic camouflage, and finally obtained A multifunctional nano-preparation with chemotherapy and photothermal therapy and cancer cell targeting. The nano-preparation has high biological safety and is simple to prepare. The stimulation of the near-infrared light triggers the disturbance of the cell membrane, and finally realizes the rapid release of the drug, which has very great application prospects.

Description

technical field [0001] The invention relates to the technical field of medical technology, in particular to a cancer cell membrane-based biomimetic multifunctional nano-preparation having the effects of chemotherapy and photothermal therapy, as well as its preparation method and application. Background technique [0002] Cancer kills millions of people every year and is a major killer of human health. The study of drug therapy for cancer has important clinical significance. However, monotherapy has its inherent limitations, which greatly limits its application in the clinical field. For example, chemotherapy is a common means of treating cancer, but its therapeutic effect is affected by dose-dependent toxicity. Therefore, many studies and clinical applications have shown that the combination of multiple treatment methods will have a synergistic and complementary effect, showing multiple advantages such as high-efficiency tumor inhibition, low side effects and delayed drug ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/46A61K9/50A61P35/00A61K31/704
CPCA61K9/5068A61K31/704A61K41/0052A61K2300/00
Inventor 刘文广张宁贾慧珍
Owner 上海揽微赛尔生物科技有限公司
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