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Oral cavity swab, preparation method and application thereof and saliva DNA acquiring and preserving method

A preservation solution and swab technology, applied in application, medical science, inoculation and ovulation diagnosis, etc., can solve the problems of poor user experience, inconvenience for collectors to carry preservatives, etc., and achieve the effect of convenient carrying and transportation, and simple sampling method.

Inactive Publication Date: 2019-02-22
广州维帝医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preservative is liquid, and the requirements for the transportation process are still high. In addition, in many cases, it is not suitable and inconvenient for the collector to carry the liquid preservative, and the user experience is poor.

Method used

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  • Oral cavity swab, preparation method and application thereof and saliva DNA acquiring and preserving method

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Experimental program
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Effect test

preparation example Construction

[0058] According to a second aspect of the present invention, a method for preparing the oral swab is provided, comprising the following steps:

[0059] Soak the fiber in the saliva DNA preservation solution, and cover the swab head after the fiber is dry to obtain a buccal swab;

[0060] or,

[0061] The fiber is covered on the swab head, then soaked in the saliva DNA preservation solution, and after drying, the oral swab is obtained.

[0062] It should be noted that the above soaking refers to soaking in excess saliva DNA preservation solution.

[0063] In the present invention, the oral swab can be obtained by soaking the fiber in the saliva DNA preservation solution, drying and covering the swab head; or covering the fiber on the swab head, then soaking in the saliva DNA preservation solution, and drying Oral swabs are available. The preparation method is simple, the operation is simple and convenient, and the implementation is easy. The invention has no special restri...

Embodiment 1

[0073] (1) A saliva DNA preservation solution

[0074] Add the surfactant tetradecyl dimethyl benzyl ammonium chloride to ultrapure water to obtain an aqueous solution with a mass fraction of tetradecyl dimethyl benzyl ammonium chloride, using a disposable filter membrane device Filter to obtain saliva DNA preservation solution.

[0075] (2) oral swab

[0076] Electrostatic flocking of nylon fibers with a fineness of 5dtex and a length of 1.8mm is applied to the end of the swab coated with an adhesive vinyl adhesive, and then soaked in the saliva DNA preservation solution obtained in step (1), at 110°C After drying for 30 minutes, oral swabs were obtained.

Embodiment 2～9

[0078] The difference between embodiment 2~9 and embodiment 1 is that the massfraction of surfactant tetradecyl dimethyl benzyl ammonium chloride is different in the step (1), the quality of surfactant in embodiment 2~9 The scores are shown in Table 1.

[0079] The massfraction of tensio-active agent in the embodiment 2~9 of table 1

[0080]

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Abstract

The invention provides an oral cavity swab, a preparation method and application thereof and a saliva DNA acquiring and preserving method and belongs to the technical field of biological agents. A swab head of the oral cavity swab is covered by fiber, the fiber is soaked with a saliva DNA preserving fluid, wherein the saliva DNA preserving fluid contains a surface active agent. The oral cavity swab obtained through soaking with the saliva DNA preserving fluid is solid, free of liquid and convenient to carry and transport and adapts to saliva DNA sampling of all people including infants and theold, weak, sick and disabled in any time period, the sampling process is completely noninvasive, and a sampling mode is simple. In addition, saliva DNA samples can be preserved at room temperature for a long time after being acquired by the oral cavity swab.

Description

technical field [0001] The invention belongs to the technical field of biological preparations, and in particular relates to a buccal swab, a preparation method and application thereof, and a method for collecting and preserving saliva DNA. Background technique [0002] Compared with the traditional way of drawing blood to collect DNA, saliva DNA sample collection is a method of obtaining DNA that is harmless and painless to the human body, and is not easy to cause discomfort and fear of the collected person. Any discomfort caused by the collector is easily accepted, thus maximizing the sampling range of genetic research, especially suitable for large-scale population investigations in molecular epidemiology. [0003] In the prior art, the collection of saliva DNA samples is mainly carried out by using cotton swabs to obtain oral mucosal epithelial cells. After the DNA is collected by this method, it needs to be stored at low temperature immediately, and the storage time is ...

Claims

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Application Information

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IPC IPC(8): A61B10/02
CPCA61B10/02A61B2010/0216
Inventor 赖晓冬邓昕
Owner 广州维帝医疗技术有限公司
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