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Use of fomepizole and its salts in the preparation of antiepileptic drugs

An anti-epileptic drug and fomepizole technology, which can be applied to fomepizole and its salts in the field of preparing anti-epileptic drugs, and can solve the problems of reducing blood drug concentration and the like

Active Publication Date: 2020-09-01
山东肽莱生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when zonisamide is used in combination with phenytoin, phenobarbital, and valproate, the former will reduce the plasma concentration of the latter

Method used

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  • Use of fomepizole and its salts in the preparation of antiepileptic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 fomepizole tablet

[0022] Raw materials: fomepiazole 700g, starch 2000g, microcrystalline cellulose 1000g, talcum powder 120g, water 700ml.

[0023] Preparation: Take the prescribed amount of starch and microcrystalline cellulose and mix them through a 100-mesh sieve; add the prescribed amount of fomepizole to the mixture of starch and microcrystalline cellulose, and then add the prescribed amount of water to prepare a soft material, and pass the soft material through a 20-mesh sieve. Granules, dried at 60 degrees Celsius, added prescription amount of talcum powder after whole grains, pressed into 10000 tablets.

Embodiment 2

[0024] Embodiment 2 fomepizole / sodium valproate tablet

[0025] Raw materials: fomepizole 500g, sodium valproate 500g, starch 2000g, microcrystalline cellulose 1000g, talcum powder 120g, water 900ml.

[0026] Preparation: take the prescribed amount of sodium valproate and pass through a 120-mesh sieve; take the prescribed amount of starch and microcrystalline cellulose and pass through a 100-mesh sieve; mix the sodium valproate, starch and microcrystalline cellulose evenly, add the prescribed amount of fomepizole and Prepare soft materials with water, granulate through a 20-mesh sieve, and dry at 60 degrees Celsius. After granulation, add the prescribed amount of talcum powder and press into 10,000 tablets.

Embodiment 3

[0027] Embodiment 3 fomepizole / sodium valproate tablet

[0028] Raw materials: fomepizole 300g, sodium valproate 600g, starch 2000g, microcrystalline cellulose 1000g, talcum powder 120g, water 900ml.

[0029] Preparation: take the prescribed amount of sodium valproate and pass through a 120-mesh sieve; take the prescribed amount of starch and microcrystalline cellulose and pass through a 100-mesh sieve; mix the sodium valproate, starch and microcrystalline cellulose evenly, add the prescribed amount of fomepizole and Prepare soft materials with water, granulate through a 20-mesh sieve, and dry at 60 degrees Celsius. After granulation, add the prescribed amount of talcum powder and press into 10,000 tablets.

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Abstract

The invention belongs to the field of medicine, and particularly relates to an application of fomepizole and a fomepizole salt to preparation of an antiepileptic drug. Preferably, the salt is fomepizole hydrochloride. The antiepileptic drug can adopt oral administration, administration by subcutaneous injection or intravenous injection, and preferably adopts oral administration. The active component of the drug can take fomepizole as the sole active component and can also contain other antiepileptic active components such as sodium valproate or lamotrigine. Furthermore, the invention providesa compound antiepileptic oral drug prepared from fomepizole, sodium valproate and oral preparation adjuvants. Fomepizole after being combined with sodium valproate has certain improving effects on attack latency and attack degree of epilepsy by oral administration.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to the use of fomepizole and its salts in the preparation of antiepileptic drugs. Background technique [0002] Epilepsy is one of the diseases of the central nervous system, and its main symptoms include sudden generalized rigidity, clonus, and convulsions. The disease is commonly known as epilepsy, epilepsy, etc., and it is more common among young and middle-aged people. According to my country's epidemiological statistics, the overall prevalence of epilepsy in my country is 7 / 1000, and the annual incidence rate is 28.8 / 100,000. There are about 9 million epilepsy patients in my country, of which 5 to 6 million are active epilepsy, and there are about 400,000 new epilepsy patients every year. Clinically, epilepsy has become the second most common disease in neurology in my country after headache. [0003] Epilepsy is divided into primary epilepsy and secondary epilepsy. In ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/415A61P25/08
CPCA61K31/415A61P25/08
Inventor 张凤田张园园孙丽丽李志武
Owner 山东肽莱生物制药有限公司
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