Hypoglycemic application of piperlongumine alkaloids

A technology of perylene amide and alkaloids, applied in the field of medicine

Inactive Publication Date: 2019-02-26
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there is only one document reporting that the ethanol extract of Piper longum fruit has a hypoglycemic eff

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hypoglycemic application of piperlongumine alkaloids
  • Hypoglycemic application of piperlongumine alkaloids
  • Hypoglycemic application of piperlongumine alkaloids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] Materials and reagents: Pseudopiperamide B and guinea-piperonylamide are obtained from the piperon; dithiothreitol (DTT), 4-nitrophenylphosphate (pNPP), pancreas Peptone, yeast extract, isopropyl β-D-Thiogalactoside (IPTG) were purchased from Sigma;

[0023] Acarbose was purchased from Merck;

[0024] The microplate reader (SpectraMax MD5) was purchased from Molecular Devices, USA.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a hypoglycemic application of piperlongumine alkaloids. The piperlongumine alkaloids comprise retrofractamide B and guineensine, in vitro alpha-glucosidase activity determination are performed on retrofractamide B and guineensine, results show that retrofractamide B and guineensine in the piperlongumine alkaloids have relatively good inhibitory effect on alpha-glucosidaseactivity and can be used for preparing drugs for treating diabetes, and a favorable material basis is provided for development of piperlongumine alkaloid drugs for treating diabetes.

Description

Technical field [0001] The present invention relates to the technical field of medicine, and relates to a hypoglycemic application of piperamide alkaloids, in particular to piperamide B and piperonamide in piperamide alkaloids in the preparation of inhibitory α-glucosidase activity the use of. Background technique [0002] Piper longum Linn. (Piper longum Linn.) is a perennial herbaceous vine, belonging to the Piperaceae (Piperaceae) Piper genus (Piper). Its dried and near-mature or mature ears are traditional Chinese medicine, Uighur medicine, Tibetan medicine, Mongolian medicine and Indian Ayurveda Commonly used medicinal materials in Tuo medicine, used for abdominal cold pain, vomiting, diarrhea, cold stagnation of qi, chest pain, heartache, headache, toothache, included in "Chinese Pharmacopoeia" and "People's Republic of China Pharmacopoeia Ministry of Health Drug Standards Uyghur "Medicine fascicle". Amide alkaloids are characteristic secondary metabolites and main active...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/4184A61P3/10
CPCA61K31/4184A61P3/10A61K2300/00
Inventor 李俊阿布杜巴克耶夫·萨德尔别克赵海清信学雷阿吉艾克拜尔·艾萨
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap