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Hypoglycemic application of piperlongumine alkaloids

A technology of perylene amide and alkaloids, applied in the field of medicine

Inactive Publication Date: 2019-02-26
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, there is only one document reporting that the ethanol extract of Piper longum fruit has a hypoglycemic effect on alloxan-induced diabetic rats, and there is no report on the hypoglycemic activity of amide alkaloids in Piper longum

Method used

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  • Hypoglycemic application of piperlongumine alkaloids
  • Hypoglycemic application of piperlongumine alkaloids
  • Hypoglycemic application of piperlongumine alkaloids

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Embodiment

[0022] Materials and reagents: Pseudopiperamide B and guinea-piperonylamide are obtained from the piperon; dithiothreitol (DTT), 4-nitrophenylphosphate (pNPP), pancreas Peptone, yeast extract, isopropyl β-D-Thiogalactoside (IPTG) were purchased from Sigma;

[0023] Acarbose was purchased from Merck;

[0024] The microplate reader (SpectraMax MD5) was purchased from Molecular Devices, USA.

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Abstract

The invention relates to a hypoglycemic application of piperlongumine alkaloids. The piperlongumine alkaloids comprise retrofractamide B and guineensine, in vitro alpha-glucosidase activity determination are performed on retrofractamide B and guineensine, results show that retrofractamide B and guineensine in the piperlongumine alkaloids have relatively good inhibitory effect on alpha-glucosidaseactivity and can be used for preparing drugs for treating diabetes, and a favorable material basis is provided for development of piperlongumine alkaloid drugs for treating diabetes.

Description

Technical field [0001] The present invention relates to the technical field of medicine, and relates to a hypoglycemic application of piperamide alkaloids, in particular to piperamide B and piperonamide in piperamide alkaloids in the preparation of inhibitory α-glucosidase activity the use of. Background technique [0002] Piper longum Linn. (Piper longum Linn.) is a perennial herbaceous vine, belonging to the Piperaceae (Piperaceae) Piper genus (Piper). Its dried and near-mature or mature ears are traditional Chinese medicine, Uighur medicine, Tibetan medicine, Mongolian medicine and Indian Ayurveda Commonly used medicinal materials in Tuo medicine, used for abdominal cold pain, vomiting, diarrhea, cold stagnation of qi, chest pain, heartache, headache, toothache, included in "Chinese Pharmacopoeia" and "People's Republic of China Pharmacopoeia Ministry of Health Drug Standards Uyghur "Medicine fascicle". Amide alkaloids are characteristic secondary metabolites and main active...

Claims

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Application Information

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IPC IPC(8): A61K31/4184A61P3/10
CPCA61K31/4184A61P3/10A61K2300/00
Inventor 李俊阿布杜巴克耶夫·萨德尔别克赵海清信学雷阿吉艾克拜尔·艾萨
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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