Use of oxygen as active ingredient for regulating intestinal flora in preparation of drugs

A technology of active ingredients and intestinal flora, applied in the field of medicine, can solve the problems of easy oxidation and carcinogenicity of vitamin C and vitamin E

Inactive Publication Date: 2019-03-05
萧湘
View PDF8 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In 2013, the U.S. Food and Drug Administration (FDA) issued a warning on hyperbaric oxygen therapy in the consumer warning section of its website: At present, there is no relevant evidence to prove that hyperbaric oxygen therapy has a clinical thera

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of oxygen as active ingredient for regulating intestinal flora in preparation of drugs
  • Use of oxygen as active ingredient for regulating intestinal flora in preparation of drugs
  • Use of oxygen as active ingredient for regulating intestinal flora in preparation of drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0259] The preparation of embodiment 1 NDDK prescription 1

[0260] Experimental drugs, instruments and reagents: Oxygen is medical oxygen; instruments are homogenizers; excipients are all pharmaceutical excipients.

[0261] Prescription composition: oxygen, surfactant, thickener, isotonic agent, wall material, water, etc.

[0262] Operation process: Take the prescribed amount of thickener and soak for 12 hours, take another isotonic agent, surfactant, and wall material to dissolve or evenly disperse in water, combine the solutions, add water and / or co-solvent to the required amount, stir, and use hydrogen Adjust the pH value of the sodium oxide solution to 7.3, filter through a 200-mesh steel mesh, sterilize at 121°C for 30 minutes, and cool. Adjust the oxygen to the desired concentration, pass through a 0.22 μm microporous membrane, and pass it into the above-mentioned high-speed stirring solution. A large number of oxygen-containing microcapsules are formed in the solutio...

Embodiment 2

[0271] Embodiment 2: the preparation of NDDK prescription 2

[0272] Prescription 2: 45% oxygen 300ml, poloxamer 13.0g, soybean lecithin 10.0g, sodium chloride 4.0g, polyvinyl acetate phthalate 7.0g, sodium hydroxide solution to adjust pH to 7.6, add water 1000ml.

Embodiment 3

[0273] Embodiment 3: the preparation of NDDK prescription 3

[0274] Prescription 3: 90% oxygen 700ml, poloxamer 17.0g, lecithin 11.0g, glycerin 7.0g, shellac 9.0g, sodium hydroxide solution to adjust pH to 8.1, add water to make 1000ml.

[0275] If the concentration of oxygen is too high, the preparation is easily oxidized, so the oxygen may be mixed with inert gas or other gases. The term "oxygen-comprising gas mixture" also includes pure oxygen.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of medicines, and relates to a medicine containing oxygen, a preparation method of the medicine and use of the medicine as a pharmaceutical active ingredient for regulating intestinal microbial communities in preparation of drugs, and particularly to the use of the medicine in preparation of the drugs for preventing or/and treating diseases related to intestinal flora imbalance. The concentration of the oxygen in the environment is a decisive factor for regulating and controlling the distribution structure of microorganisms in the environment.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to medicines containing oxygen, a preparation method thereof and their use as medicine active ingredients for adjusting intestinal flora structure in medicine preparation. Specifically relates to the use in the preparation of medicines for preventing or / and treating diseases related to intestinal flora imbalance, including the preparation of medicines for preventing or / and treating obesity, diabetes, hypertension, cancer and Alzheimer's disease use in . Background technique [0002] Oxygen is one of the most important substances in life activities. [0003] Oxygen (O 2 ), the most common elemental form of oxygen. It is not easily soluble in water, accounting for about 21% in the air. Under normal pressure, when the concentration of oxygen exceeds 40%, it may cause oxygen poisoning, and the long-term partial pressure of oxygen (PaO 2 ) in an environment of 60 kPa to 100 kPa (equi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K33/00A61P1/00A61P3/04A61P3/10A61P9/12A61P25/28A61P33/10A61P35/00
CPCA61K33/00A61K9/50A61P1/00A61P3/04A61P3/10A61P9/12A61P25/00A61P25/28A61P33/10A61P35/00
Inventor 萧湘
Owner 萧湘
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap