32 results about "Binding Determinants" patented technology

Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. A separate fusogenic molecule is also present on the envelope and facilitates delivery of the polynucleotide across the membrane and into the cytosol of the target cell. The methods and related compositions can be used for treating patients having suffering from a wide range of conditions, including infection, such as HIV; cancers, such as non-Hodgkin's lymphoma and breast cancer; and hematological disorders, such as severe combined immunodeficiency.

The present invention provides methods of making antibodies having the binding specificity of a reference antibody. Antibodies generated by the methods of the inventions have at least one minimal essential binding specificity determinant from a heavy chain or light chain CDR3 from the reference antibody. The method can be used, e.g., in humanization procedures. The invention also provides libraries and antibodies made in accordance with the methods.

The present invention provides a comprehensive method to design an automatic media audience measurement system that can estimate the site-wide audience of a media of interest (e.g., the site-wide viewership of a target display) based on the measurements of a subset of the actual audience sampled from a limited space in the site. This invention enables (1) the placement of sensors in optimal positions for the viewership data measurement and (2) the estimation of the site-wide viewership of the target display by performing the viewership extrapolation based on the sampled viewership data. The viewership extrapolation problem is formulated in a way that the time-varying crowd dynamics around the target display is an important decisive factor as well as the sampled viewership data at a given time in yielding the estimated site-wide viewership. To solve this problem, the system elements that affect the viewership—site, display, crowd, and audience—and their relationships are first identified in terms of the visibility, the viewership relevancy, and the crowd occupancy. The optimal positions of the sensors are determined to cover the maximum area of the viewership with high probabilities. The viewership extrapolation function is then modeled and learned from the sampled viewership data, the site-wide viewership data, and the crowd dynamics measurements while removing the noise in the sampled viewership data using the viewership relevancy of the measurements to the target display.

A computerized method and system for detection and quantification of changes in color on skin or internal tissue or organs within the human body. Digital images of the skin or tissue containing an area of interest are analyzed using the software of the invention, based on at least one channel of the LAB color system. The invention calculates the intensity and distribution of color present within the predetermined area of interest, and results in display of at least one color information attribute. The invention allows color calibration of the image to be performed in relation to a reference label having predetermined colors which surrounds the area of interest, prior to the analysis. The invention allows a threshold analysis to be performed, which graphically depicts the size and location of areas exhibiting significant change in color, which is a determinant factor in medical diagnosis.

The invention relates to a device and a method for measuring temperature and radioactive rays with fiber bragg grating (FBG) sensors. The invention relates to a technology that accurate measurement can be carried out by covering a hollow radioactive ray shielding member on a sensor with two FBG sensors to separate the radioactive ray values and temperature values obtained from the two sensors. According to the invention, no matter in a nuclear station in a normal state or an apparatus generating the radioactive rays, the device can be used as a commonly used sensor system for measuring temperature and radioactive ray quantity, and also realizes commercialization. When a nuclear accident happens, the device also can be used as a sensor system which can remotely measure the temperature and radioactive ray radiation quantities that play critical facts for mastering inner information of accident environment by means of a fiber circuit.

The invention discloses an additive for a positive pole of a lead-carbon battery, which is highly controllable in component and crystal form and a preparation method of a pole plate for the positive pole of the lead-carbon battery. The additive is an alpha / beta-PbO2-SiO2 compound which is prepared by constant-current electrodeposition; the pole plate is prepared from lead powder, alpha / beta-PbO2-SiO2, colloidal graphite and a short fiber. As an excellent electrolyte storage medium, silicon dioxide has certain elastic deformation ability, after being added into the positive role of the lead-carbon battery, while being capable of providing more effective reactive ions for an internal active substance, is used for providing physical buffer action when the pole plate generates deformation, andis used for relieving the phenomenon that lead plaster falls off due to geometrical bending. However, lead dioxide is used as a basic active substance for the positive pole; the crystal form of the lead dioxide is a decisive factor of influencing the electrochemical property of a material. The pole plate prepared from the compound provided by the invention can be used for obviously improving theeffective utilization ratio of an active substance and the corrosion-resistant ability of the pole plate; the falling-off phenomenon in a high-rate partially charged state is effectively relieved, andthe overall energy density and cycle life of the battery are improved.

The invention relates to a photovoltaic module cleaning method. The method comprises steps: 1) related data for decisive factors influencing whether the photovoltaic module is cleaned or not are acquired, the data are processed, and accurate values of the decisive factors which are a generation gain level, a sediment transport rate, a precipitation amount and a module masking rate influencing whether the photovoltaic module is cleaned or not are obtained; 2) the accurate values of the generation gain level, the sediment transport rate, and the precipitation amount obtained in the first step are fed to a first-stage fuzzy controller for processing, and an initial cleaning index, that is, the initial cleaning probability of the photovoltaic module, is obtained; and 3) the accurate value of the module masking rate obtained in the first step and the initial cleaning index obtained in the second step are fed to a second-stage fuzzy controller for processing, and a cleaning decisive index is obtained. Thus, a decisive data support is provided for cleaning of the photovoltaic module, the defect that the original photovoltaic module cleaning decision subjective consciousness is strong is broken, and thus, cleaning and maintenance of the photovoltaic power station module are more scientific.

The invention discloses an unrestrictive expected operation life assessment method for a distribution network lightning arrester under a given confidence level. The method comprises the following steps of: 1, monitoring the lightning overvoltage amplitudes at the installation position of the lightning arrester in one year, and counting the amplitude distribution; 2, calculating the statistical distribution of lightning impact discharge capacity resource consumption of the lightning arrester in one year; and 3, calculating the unrestrictive / restrictive lightning overvoltage expected life of the lightning arrester under the given confidence level. According to the method, the lightning overvoltage serving as a decisive factor of the service life of the lightning arrester for a distribution network is analyzed, a route and a method for calculating lightning discharge capacity resource of the lightning arrester for the distribution network and one-time lightning arrester lightning discharge capacity resource consumed by overhead circuit overvoltage due to lightning are further introduced, and finally, the expected operation life of the lightning arrester for the distribution network is calculated by adopting simplified parameters and the method.