54results about How to "Boost protein levels" patented technology

A role of the human PDE4D gene in stroke is disclosed. Methods for diagnosis, prediction of clinical course and treatment for stroke using polymorphisms in the PDE4D gene are also disclosed.

The invention provides a method for inhibiting an intracellular target in a cell with a bispecific antibody comprising contacting the cell with a bispecific antibody having a first Fv fragment with a cell-penetrating determinant and a second Fv fragment with an intracellular target-binding determinant under suitable conditions so that the first Fv fragment causes the bispecific antibody to enter the cell and the second Fv fragment binds the intracellular target in the cell and thereby inhibiting the intracellular target.

A role of the human PDE4D gene in stroke is disclosed. Methods for diagnosis, prediction of clinical course and treatment for stroke using polymorphisms in the PDE4D gene are also disclosed.

The inventions is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (‘CPMV-HT’) based protein expression system.

The present invention relates to protein separation systems and methods capable of resolving and characterizing large numbers of cellular proteins. In particular, the present invention provides a novel mass mapping system and methods for the differential display of proteins. The present invention further provides novel methods for displaying differential protein expression between two samples. In particular, the present invention provides novel method of mapping differential expression of proteins in non-cancerous, pre-cancerous, and cancerous cells.

A process for extraction of edible protein from corn germ. The process includes providing a defatted corn germ with a fat concentration of less than about 5% by weight, milling the corn germ to a granulation of less than about 100 US mesh at less than 180° F., preparing a slurry from the milled corn germ, extracting a edible protein solution from the slurry, recovering the edible protein by precipitating agents (ethanol, acids), and drying the edible protein. The resulting food is 80% to 90% protein.

This present invention discloses a method for treating and / or preventing neurodegenerative diseases by applying low-intensity pulsed ultrasound (LIPUS) stimulation. In addition, this present invention discloses the LIPUS increases neurotrophic factor protein expression, improves cognitive dysfunction and reduces brain damage in neurotoxicity.

The invention provides compositions and methods for treating neurodegenerative disorders. The method of the invention involves administering to an individual in need of treatment a composition having an R-NSAID or a derivative thereof and a SSRI. The methods and compositions of the invention are useful for treating and preventing neurodegenerative disorders such as Alzheimer's disease, dementia, and mild cognitive impairment.

The present invention provides a more nutritious milk chocolate composition. The milk chocolate composition contains greater than 40% natural milk solids by weight. Method for preparing the milk chocolate composition is also provided. In another embodiment, the invention provides a reduced-sugar milk chocolate composition containing greater than 40% natural milk solids by weight and a sweetener component in an amount of not greater than 38% by weight of the resulting milk chocolate composition.

The present disclosure describes high protein snack chips comprising meat, seafood and / or poultry powder that adds animal-sourced protein and / or flavors without entraining problematic moisture in precursor dough used to make the chips. The present disclosure also encompasses methods for producing high protein snack chips comprising the steps of making dough comprising meat, seafood and / or poultry powder along with various dry, wet and, optionally, fat ingredients, sheeting the dough, optionally baking the sheeted dough, cutting the uncooked or baked sheeted dough into pieces, and baking and / or frying the pieces to produce tasty, reduced fat, crispy, crunchy snack chips.

Methods and materials for modulating, e.g., increasing or decreasing, protein levels in plants are disclosed. For example, nucleic acids encoding protein-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Also disclosed are plants having increased protein levels and plant products produced from plants having increased protein levels.

The inventions is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (‘CPMV-HT’) based protein expression system.

Methods and compositions are provided for treating human synovial sarcoma (SS). Also provided are screens to identify therapeutics for the treatment of synovial sarcoma. These methods, compositions, and screens are based on the discovery that promoting the assembly of wild type BAF (also called mSWI / SNF) complexes in SS cells by increasing levels of wild type SS18 and / or decreasing levels of SS18-SSX fusion protein leads to the cessation of proliferation of malignant cells in synovial sarcoma.

The present invention relates to a composition for preparing gluten-free or gluten-reduced bakery products, comprising enzyme active soy flour and at least one hydrocolloid, as well as a kit of a plurality of ingredients for preparing gluten-free or gluten-reduced bakery products, comprising said enzyme active soy flour and said at least one hydrocolloid. The present invention further relates to a dough comprising said composition, and to a gluten-free or gluten-reduced bakery product, in particular bread or a bread product, produced using said composition. In addition, the present invention relates to the use of enzyme active soy flour or a combination of enzyme active soy flour and at least one hydrocolloid in the preparation of a gluten-free or gluten-reduced, preferably gluten-free, bakery product.

A method of producing an enriched flavonoid aglycone extract from starting material containing a suitable flavonoid glycoside and / or conjugate thereof comprising the steps of: (i) enzymatically converting the flavonoid glycoside or conjugate thereof into the flavonoid aglycone; (ii) adjusting the pH to render the flavonoid aglycone soluble and removing the insoluble fraction; and (iii) adjusting the pH to render the soluble flavonoid aglycone relatively insoluble and forming an extract containing the same.

The invention relates to proteins for use as a marker for the efficacy of sublingual immunotherapy. In particular, the proteins may be used to predict the responsiveness of a patient to immunotherapy. The invention may find use in selecting patients as suitable candidates for immunotherapy.

The present invention discloses a silurus asotus feed phagostimulant and a preparation method thereof, and belongs to the technical field of feed additive preparations. Based on nutritional requirements of silurus asotus and water body environment, and combining food intake characteristics, a formula of raw materials is optimized. The silurus asotus feed phagostimulant scientifically combines compound flavor peptides greatly improving palatability and feed utilization rate, having a relatively strong anti-oxidation effect and eliminating free radicals; an accharomyces cerevisiae culture having functional characteristics of being strong in nutrition, biological activity, oxidation resistance, etc.; a high-calcium cerasus humilis extract effectively supplementing calcium, iron and soluble fibers, having a strong embedding effect and prolonging a shelf life; artemisia carvifolia seed powder significantly improving antifreeze effects and stability, improving water resistance and gloss, and enhancing and promoting palatability; and wheat malt powder providing rich nutrients, bioactive substances and plant enzyme sources. Finally, the prepared silurus asotus feed phagostimulant is strong in phagostimulant and good in production performances.

The invention discloses a mixed pellet feed directly prepared from optimally-proportioned dry matter of whole-plant corn in a squeezing and extruding mode. The whole-plant corn is mechanically harvested and smashed at the same time, and then is subjected to squeezing dewatering; squeezed-out liquid is concentrated and then is adsorbed with loess, and drying and smashing are carried out; a product is added into a squeezed dry material and the product and the squeezed dry material are mixed evenly; extruding and pelletizing are carried out, and the mixed pellet feed is obtained. The obtained pellet feed is in a yellow green color, is clumpy and does not go mouldy; the moisture content is 7.5-12.8%, the crude protein content is 6-14%, the crude fat content is 1.2-4.7%, the crude fiber content is 43.49-63%, the crude ash content is 21-43%, the nitrite content is 3.1-15.2 mg / kg, and the density is 412-526 kg / m<3>. The nutritional value and the palatability of the pallet feed are both significantly improved, the dry matter and nutritional ingredients in the corn can be preserved in the pallet feed for the longest time, the purposes of timely harvesting, processing, storing and transporting of the feed are achieved, and the feed conversion ratio is greatly increased.

This invention relates generally to nucleic acid sequences encoding proteins that are related to the presence of seed storage compounds in plants. More specifically, the present invention relates to FAD2-like nucleic acid sequences encoding lipid metabolism regulator proteins and the use of these sequences in transgenic plants. In particular, the invention is directed to methods for manipulating lipid metabolism related compounds and for increasing oil level and altering the fatty acid composition in plants and seeds. The invention further relates to methods of using these novel plant polypeptides to stimulate plant growth and / or to increase yield and / or composition of seed storage compounds.

The invention provides a method for inhibiting an intracellular target in a cell with a bispecific antibody comprising contacting the cell with a bispecific antibody having a first Fv fragment with a cell-penetrating determinant and a second Fv fragment with an intracellular target-binding determinant under suitable conditions so that the first Fv fragment causes the bispecific antibody to enter the cell and the second Fv fragment binds the intracellular target in the cell and thereby inhibiting the intracellular target.

The present invention provides compositions and a method for monitoring breast cancer treatment.

The invention discloses feed for sows during gestation. The feed is prepared from the following raw materials in percentage by mass: 58% of yellow corn, 4% of alfalfa, 4% of soybeans, 8% of bean pulp, 2% of largeanther senna, 5% of sweet potatoes, 10% of silkworm chrysalis, 3.5% of fish meal, 4% of meat and bone meal, 0.5% of egg-shell powder, 0.3% of salt, 0.3% of calcium carbonate, 0.1% of calcium hydrogen phosphate, 0.2% of vitamin additives, 0.05% of ferrous sulfate, 0.02% of zinc sulfate, 0.01% of lysine, 0.01% of methionine and 0.01% of oxytetracycline. The feed disclosed by the invention is relatively high in energy and protein level, relatively balanced in nutrient, and capable of meeting both the breeding needs and the pig growth needs. The oxytetracycline is used in the formula, so that the immunity of the sows can be improved, the breeding rate can be guaranteed, and the yield-increasing effect can be achieved.

The invention discloses a catfish feed compound enzyme and a preparation method thereof. The preparation method of the catfish feed compound enzyme is characterized by taking nutritional requirement of the catfish and the water environment as the basis, optimizing the raw material formula, combining digestion characteristics of the catfish and scientifically compounding a wine making yeast culture material with functional characteristics such as high nutrition performance, high biological activity, high oxidation resistance and the like, a calcium fruit extract capable of effectively supplementing calcium, iron and soluble fiber, providing powerful embedding effect and prolonging the quality guarantee period of the feed compound enzyme, wormwood seed powder capable of obviously improving anti-freezing effect and stability of the feed compound enzyme, improving water resistance and glossiness of the catfish feed and reducing powder content in the feed, a palatable agent capable of greatly improving palatability and digestion rate of the feed, and wheat malt flour capable of providing rich nutrient materials, biological active materials and plant enzyme sources to finally obtain the catfish feed compound enzyme capable of obviously enhancing digestion rate and parturition performance of the catfish, reducing the feed coefficient, preventing water pollution and maintaining high water quality.

Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the production of polyamines by omithine decarboxylase (ODC) and the transport of polyamines by its corresponding polyamine transporter. These compounds will preferably enter the cell independent of the polyamine transporter. As drugs, these compounds are used to treat any disease associated with cellular proliferation including but not limited to cancer.

The invention discloses a high-yield catfish feed attractant and a preparation method thereof and belongs to the technical field of feed additive preparation. The high-yield catfish feed attractant and the preparation method thereof have the advantages that the nutritional requirements of catfish and water environments are combined with the ingestion features of the catfish to optimize a raw material formula, raw materials are scientifically compounded to greatly increase palatability and feed utilization rate, and the attractant comprises compound flavor peptide which has high anti-oxidation effect and is capable of removing free radicals; the high-yield catfish feed attractant contains saccharomyces cerevisiae culture with functional features such as high nutrition, high bioactivity and high oxidation resistance, Prunus Humilis Bunge extract which can effectively supplement calcium, iron and soluble fibers, has a powerful embedding effect and can prolong shelf life, wormwood seed powder which can evidently increase an anti-freezing effect and stability, increase water resistance and glossiness, enhance and promote palatability and lower powder content, and wheat malt powder which can provide rich nutritional substances, bioactive substances, fragrant substances and plant enzyme sources; the prepared high-yield catfish feed attractant is high in palpability and good in production performance.

The invention discloses a high-digestion high-utilization-rate catfish feed, and belongs to the technical field of processing of catfish feeds. Based on nutritional requirements of catfish and water body environment, the digestion characteristics of the catfish are combined, the formula of a conventional catfish feed is optimized, and a feed complex enzyme, wormwood seed powder, a prunus humilis bunge extract and a phagostimulant are scientifically compounded, so that the catfish feed can be prepared, wherein the feed complex enzyme can effectively degrade anti-nutritional factors in the catfish feed, increase the utilization rate of nutrient substances of starch, protein, minerals and the like, increase the protein level, the organism antioxidative activity and the digestive absorption rate of the catfish, significantly increase the digestibility and the production properties of the catfish, reduce the feed coefficient, prevent the water bodies from being polluted and maintain good water quality is scientifically compounded; the wormwood seed powder can significantly improve the caking property, the water resistance, the glossiness and the frost resistance of the catfish feed and reduce the powder containing rate of the feed; the prunus humilis bunge extract can effectively complement calcium, ferrum and soluble fibers; the phagostimulant can substantially improve the palatability of the feed; and therefore, the catfish feed is good in feed coefficient, high in digestibility, good in production properties, high in propagation properties, high in disease resistance, high in palatability and low in cost.

Methods and compositions are provided for treating human synovial sarcoma (SS). Also provided are screens to identify therapeutics for the treatment of synovial sarcoma. These methods, compositions, and screens are based on the discovery that promoting the assembly of wild type BAF (also called mSWI / SNF) complexes in SS cells by increasing levels of wild type SS18 and / or decreasing levels of SS18-SSX fusion protein leads to the cessation of proliferation of malignant cells in synovial sarcoma.

The invention relates to proteins for use as markers for the efficacy of sublingual immunotherapy. In particular, the proteins may be used to predict the responsiveness of a patient to immunotherapy. The invention may find use in selecting patients as suitable candidates for immunotherapy.

The invention discloses a catfish feed complex enzyme containing a yeast culture and a preparation method thereof. The complex enzyme is characterized in that on the basis of catfish nutrient requirements and water body environment, and the digestion characteristics of catfish, the formula of raw materials is optimized, a wine-brewing yeast culture, a prunus humilis bunge extract, wormwood seed powder, a palatable agent and wheat malt powder are scientifically compounded, wherein the wine-brewing yeast culture has function characteristics of strong nutrient property, biological activity, anti-oxidizing property and the like; the prunus humilis bunge extract can effectively supplement the calcium, iron and soluble fiber, has strong encapsulating function, and can extend the quality warranty period of the feed complex enzyme; the wormwood seed powder can obviously improve the anti-freezing effect and stability of the feed complex enzyme, improve the water-resistant property and luster of the catfish feed, and reduce the powder content in the feed; the palatable agent can greatly improve the palatability and digestion rate of the feed; the wheat malt powder can provide rich nutrient substances, biological active substances and plant enzyme sources. The complex enzyme of the catfish feed containing the yeast culture has the advantages that the digestion rate and yield rate of the catfish are obviously increased, the feed coefficient is reduced, the pollution to a water body is decreased, and the high water quality is maintained.

The present disclosure provides a method for treating and / or preventing nephrotic syndrome, such as but not limited to minimal change disease and membranous nephropathy, and conditions related to nephrotic syndrome, such as but not limited to, proteinuria and edema, as well as diabetic nephropathy, diabetes mellitus, lupus nephritis or primary glomerular disease. The present disclosure further provides methods for reducing proteinuria and other disease states as discussed herein. Such methods comprise the therapeutic delivery of an Angptl4 polypeptide or Angptl4 polypeptide derivative to a subject.