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Application of compound in preparation of nerve protection and/or nerve repair related products

A technology of related products and compounds, applied in the field of use in the preparation of drugs for diseases related to nerve damage, can solve unseen problems and achieve the effect of promoting differentiation

Active Publication Date: 2019-03-08
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, this compound is mainly used as a raw material for the synthesis of anti-cancer, hypolipidemic, anti-cardiovascular and cerebrovascular diseases, antibacterial, anti-inflammatory and other drugs. There are no reports about 5,7-dihydroxyflavone being used for neuroprotection and repair.

Method used

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  • Application of compound in preparation of nerve protection and/or nerve repair related products
  • Application of compound in preparation of nerve protection and/or nerve repair related products
  • Application of compound in preparation of nerve protection and/or nerve repair related products

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Experimental program
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Embodiment Construction

[0038] Next, the application of the present invention will be further described through specific examples and specific experiments, and the protective and repairing effects of the compound I on nerves will be verified and explained.

[0039] 1. Materials and methods

[0040] 1. Cells, Drugs and Reagents

[0041] Rat adrenal pheochromoma cells (PC12 cells, Shanghai Institute of Cells, Chinese Academy of Sciences); MSC cells (self-extracted, derived from bone marrow mesenchyme of SD rats aged 3-4 weeks); high-glucose DMEM medium (Hyclone, J180003) , L-glutamic acid solution (Glu, LEAGENE, 0404A18); Tetramethylazozolium salt (MTT powder, Ruisai Biological Company, 180315); DAPI (Google Biological Co., Ltd., 20180326); FITC-labeled goat anti-mouse IgG (H+L) (Beyond Biotech, A0562); NGF primary antibody (Google Bio, GB11143); BDNF primary antibody (Google Bio, GB11240); fluorescent secondary antibody CY3 goat anti-rabbit (Google Bio, GB21303); GalC primary antibody (Solarbio, K00...

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PUM

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Abstract

The invention provides application of a compound in the preparation of nerve protection and / or nerve repair related products, and provides application of the compound (I) in the preparation of neurophic growth factor enhancers and trophic nerve drugs. Through a drug screening model, the compound has a neuroprotective effect, and experiments indicate that endogenic stem cell expressed NGF and BDNFtrophic factors are important mechanisms of the compound for curing cerebral ischemia-reperfusion injury, so that drugs for preventing or curing nervous system related diseases such as cerebral ischemia-reperfusion injury are prepared.

Description

technical field [0001] The present invention relates to the field of medical applications of compounds, in particular to the application of compounds in the preparation of medicines for diseases related to nerve damage. Background technique [0002] Cerebral ischemia is a serious cerebrovascular disease in which intracranial vascular occlusion causes abnormal cerebral blood flow, resulting in focal brain tissue damage and neurological dysfunction. Cerebral ischemia is the most common clinical cerebrovascular disease, accounting for about 80%. The disease has a high morbidity rate, high disability rate, and high mortality rate, which reduces the self-care ability of patients and seriously endangers human health and life. After the onset of cerebral ischemia, an ischemic cascade reaction occurs. Oxidative stress and excitotoxicity occur in the infarct area due to ischemia, which destroys the balance of water and electricity ions, resulting in the death of neurons in the infarc...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P25/00
CPCA61K31/352A61P25/00
Inventor 谭锐谭立伟王叶叶
Owner SOUTHWEST JIAOTONG UNIV
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