A kind of preparation method of nicorandil dimer

A nicorandil dimer and nicorandil technology are applied in the field of preparation of nicorandil dimer and can solve the problem of low nicorandil dimer yield and limiting nicorandil dimerization The research work of bulk impurities, the difficulty of obtaining and other problems, to achieve the effect of rapid acquisition, good purity and high yield
CN109516950BActive Publication Date: 2022-02-18BURNING POINT (NANJING) BIOPHARMACEUTICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BURNING POINT (NANJING) BIOPHARMACEUTICAL TECH CO LTD
Publication Date
2022-02-18

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Abstract

The invention provides a preparation method of nicorandil dimer, comprising the following steps: (1) dissolving nicorandil in an organic solvent, stirring and reacting for 2‑6 h; (2) cooling down slowly to Slowly add a crystallization solvent to the reaction solution at room temperature, stir to crystallize, filter to obtain the crude product, and wash with an organic solvent; (3) Add the above crude product to the recrystallization solvent, and after recrystallization, solid Nicorandil is obtained Dimeric nitrate. The preparation method of the nicorandil dimer disclosed by the invention can conveniently and rapidly obtain the nicorandil dimer, and the obtained nicorandil dimer has a high yield and good purity.
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Description

technical field

[0001] The invention relates to the field of medicinal chemistry, in particular to a preparation method of nicorandil dimer. Background technique

[0002] Nicorandil (Nicorandil) was developed by Chugai Pharmaceutical Co., Ltd. in Japan and was launched in Japan in 1984. Nicorandil is an antiangina pectoris drug, which belongs to nitrate ester compound. It has the functions of preventing intracellular calcium ion dissociation, increasing the permeability of cell membrane to potassium ion, dilating coronary blood vessels, continuously increasing coronary blood flow, and inhibiting coronary artery spasm. The role of dilating coronary vessels does not affect blood pressure, heart rate, myocardial contractility and myocardial oxygen consumption. Nicorandil also has the effect of inhibiting platelet aggregation and preventing thrombosis. Nicorandil, chemical name: N-(2-hydroxyethyl) nicotinamide nitrate, structural formula:

[0003]

[0004] The content of t...

Claims

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