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Application of carboxymethyl chitosan in preparation of dentin collagen fiber demineralization material

A technology of carboxymethyl chitosan and collagen fibers, applied in dentistry, dental prosthesis, dental preparations, etc., can solve the problems of short service life of bonded restorations, achieve excellent macromolecular properties, excellent mechanical strength, The effect of excellent calcium ion chelating ability

Active Publication Date: 2022-03-08
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The degradation of collagen fibers and resin components in this weak area in the water-rich microenvironment is the root cause of the short service life of the currently generally accepted adhesive restorations

Method used

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  • Application of carboxymethyl chitosan in preparation of dentin collagen fiber demineralization material
  • Application of carboxymethyl chitosan in preparation of dentin collagen fiber demineralization material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The material of this embodiment is to adopt the N-carboxymethyl chitosan of molecular weight 100-1000KDa, it is dissolved in deionized water to prepare the carboxymethyl chitosan solution that mass percent concentration is 1%, after dissolving completely under room temperature A dentin collagen fiber demineralized material is obtained, and the pH of the obtained demineralized material is 6.73.

[0027] Use an injection device to apply the demineralizing agent on the surface of the dentin, rinse it with deionized water for 10 seconds after treatment for 30 seconds, and blow it with water-free and oil-free compressed air for 10 seconds (dry bonding) or use absorbent paper to gently dry the surface moisture (wet bonding). bonding), followed by bonding with dentin cement.

[0028] According to the description of embodiment 1, the demineralizing agent material of the present invention has the following characteristics:

[0029] (1) if figure 1 Shown are the infrared spectr...

Embodiment 2

[0032] This embodiment differs from Embodiment 1 in that:

[0033] The material of this embodiment is to adopt the N of molecular weight 60-1000KDa, N-carboxymethyl chitosan, it is dissolved in deionized water to prepare the carboxymethyl chitosan solution that mass percentage concentration is 0.5%, after dissolving completely The dentin collagen fiber demineralized material was obtained, and the pH value of the demineralized material in this embodiment was 7.1.

Embodiment 3

[0035] This embodiment differs from Embodiment 1 in that:

[0036] The material of this embodiment is to adopt N-carboxymethyl chitosan and N,N-carboxymethyl chitosan with molecular weight 100-1000KDa, respectively dissolve in deionized water to prepare carboxymethyl shell with a mass percentage concentration of 0.1%. As for the polysaccharide solution, the dentin demineralization agent is obtained by mixing the two solutions in equal volumes, and the pH value of the demineralization material in this embodiment is 6.54.

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Abstract

The invention discloses the application of carboxymethyl chitosan in the preparation of dentin collagen fiber demineralization materials. The invention also provides the preparation of dentin collagen fiber demineralization materials from carboxymethyl chitosan and deionized water, wherein carboxymethyl chitosan The mass percent concentration of chitosan is 0.1%-1%. The demineralization material of the present invention can be used for dentin demineralization treatment before direct or indirect dental restoration, can selectively remove minerals outside dentin collagen fibers, retain the physical and mechanical properties of demineralized collagen to the greatest extent, and effectively fight against bacterial infection , reduce the degradation and damage of the bonding interface, and improve the clinical service life of the bonding repair. The demineralized material according to the invention is particularly suitable for the less technically sensitive "dry bonding" restoration technique.

Description

technical field [0001] The invention belongs to the field of dental bonding restoration materials, and relates to the application of carboxymethyl chitosan for preparing dentin collagen fiber demineralization materials. Background technique [0002] Tooth defects caused by caries, tooth trauma, wear, wedge-shaped defect, acid erosion and developmental deformity often cause damage to normal tooth shape, occlusal and adjacency, and damage to chewing, development, face, pulp and periodontal tissue. Even have adverse effects on the health of the whole body. Resin bonding restoration technology, with its unique retention principle, outstanding aesthetic restoration effect and convenient operation, is the core key technology for tooth defect preservation and restoration, and is widely used in many fields of dental clinical medicine. [0003] The current dentin bonding, whether using full-etch adhesives or self-etch adhesives, requires the use of phosphoric acid or other organic a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/898
CPCA61K6/898C08L5/08
Inventor 余凡许荣宸牛丽娜陈吉华郑智明焦凯
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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