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A kind of swainsonine antigen and its preparation method

A swainsonine and antigen technology, applied in chemical instruments and methods, peptides, animal/human proteins, etc., can solve the problems of economic losses in animal husbandry production, not being effectively controlled, affecting growth and reproduction, etc. Easy operation and high coupling ratio

Active Publication Date: 2022-04-26
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chronic poisoning caused by animals eating locoweeds affects growth and reproduction, and even dies, causing huge economic losses to animal husbandry production, which has not been effectively controlled so far

Method used

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  • A kind of swainsonine antigen and its preparation method
  • A kind of swainsonine antigen and its preparation method
  • A kind of swainsonine antigen and its preparation method

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Embodiment Construction

[0016] The preferred embodiments of the present invention will be described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0017] Example 1 Preparation method of swainsonine antigen

[0018] 1.1 Materials and methods

[0019] 1.1.1 Main materials

[0020] Swainsonine (SW) was provided by the Drug Research Laboratory of Lanzhou Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences. Monoethyl glutaric acid chloride, Bailingwei Technology Co., Ltd. Bovine Serum Albumin (BSA), Runde Biological Products. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC.HCl): Shandong West Asia Chemical Industry Co., Ltd., Hydroxybenzotriazole (HOBt): Shanghai Yantuo Biology Technology Co., Ltd., dialysis bag (3500) imported from the United States:...

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Abstract

The invention discloses a swainsonine antigen, which has the following chemical structure formula: wherein, BSA is bovine serum albumin. Its preparation process includes: (1) swainsonine reacts with glutaric acid monoethyl chloride to obtain compound I: compound I is dechlorinated under the action of alkali, and acidified to obtain compound II: Under the action of propyl)-3-ethylcarbodiimide hydrochloride and 1-hydroxybenzotriazole, the compound II is condensed with BSA to obtain the described swainsonine antigen. The synthesis process of the swainsonine antigen of the invention is simple, easy to operate, low in cost and high in coupling ratio, and the antigen can produce high-titer antibodies, opening up a new way for the rational development and utilization of locoweed plants.

Description

technical field [0001] The invention relates to a swainsonine antigen and a preparation method thereof. Background technique [0002] Locoweed is the most serious poisonous plant in many areas such as western my country, mainly including poisonous plants of the genus Astragalus and Oxytropis in leguminous plants, which have a large area in my country and many other countries in the world distributed. Animals eating locoweeds cause chronic poisoning, affect growth and reproduction, and even die, causing huge economic losses to animal husbandry production, which have not been effectively controlled so far. However, in addition to toxic components, locoweed also contains a large amount of nutrients such as protein and trace elements; at the same time, locoweed has a well-developed root system and strong stress resistance. Conducive to the development of grassland animal husbandry. In addition, studies have also proved that locoweed has immune regulation function and can inhib...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/765
CPCC07K14/765C07K19/00
Inventor 梁剑平刘宇梁妍王宝海郝宝成王学红刘建枝王金龙夏晨阳郭文柱赵凤舞陶蕾贾忠张新刚
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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