Pyrimidine antitumor compound and its preparation method and application

A compound and anti-tumor technology, applied in the field of medicine, can solve problems such as reducing bioavailability
CN109705045BInactive Publication Date: 2020-07-14中国医科大学
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
中国医科大学
Publication Date
2020-07-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of medicines and particularly relates to a pyrimidine-type antitumor compound, a preparation method and an application thereof. In the invention, the medicinal effect characters of a pyrimidine analogue and a TP inhibitor are analyzed; the invention is to design a series of novel compounds, having the bio-effects of both compounds, through a splicing principle. Pharmacological research proves that the compounds have certain inhibition activity on human lung cancer A549 cells, human ovarian cancer OVCAR-3 cells and human gastric cancer SGC-7901 cells.
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Description

technical field

[0001] The invention belongs to the field of medicine, and specifically relates to a pyrimidine antitumor compound and a preparation method and application thereof. Background technique

[0002] Cancer is a malignant tumor originating from epithelial tissue. It is a disease characterized by rapid cell proliferation and metastasis. The death rate ranks first among all diseases. According to the latest global cancer data released by the International Agency for Research on Cancer, there were 14.1 million new cancer patients in the world in 2012, and the annual growth rate will increase by 11%. Therefore, the treatment of cancer has been paid close attention to all over the world.

[0003] At present, there are four main ways to treat cancer in the adjacent bed: surgery, radiation therapy, chemotherapy, and immunotherapy. Compared with the other three methods, chemical drug treatment is generally painless, and its lethality to cancer cells is difficult to achi...

Claims

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