Pepper extract and application thereof

A kind of Zanthoxylum bungeanum extract and extract technology, applied in the field of medicine, can solve the problems of low active ingredient content, undetectable pharmacological activity, etc.

Active Publication Date: 2019-05-21
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Even the extract extracted by a certain extraction method, because its active ingredi

Method used

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  • Pepper extract and application thereof
  • Pepper extract and application thereof
  • Pepper extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Preparation of Zanthoxylum bungeanum extract by cold soaking in 95% ethanol

[0059] 23.5kg of dried pericarp of Zanthoxylum bungeanum, crushed and extracted 3 times with 5 times volume of 95% ethanol (temperature: 20-25°C), 7 days each time, combined the extracts, filtered, and concentrated the filtrate under reduced pressure to obtain 95% ethanol extraction 5.1kg.

Embodiment 2

[0061] Preparation of Pepper 95% Ethanol Extract from Petroleum Ether

[0062] The 95% ethanol extract obtained in Example 1 was evenly mixed on 10 kg of diatomaceous earth, fully absorbed and dried, then packed into a column, eluted with petroleum ether for 2-4 column volumes, and after recovering the solvent, 1250 g of petroleum ether fractions were obtained. Labeled as P site.

Embodiment 3

[0064] Sample preparation of 95% ethanol extract of Zanthoxylum bungeanum in dichloromethane

[0065] The column eluted in Example 2 was eluted with dichloromethane, and after recovering the solvent, 470 g of the dichloromethane fraction was obtained. Labeled C site.

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Abstract

The invention provides a pepper extract and a preparation method and application thereof. The pepper extract is extracted and refined from different parts of pepper, has antidepressant activity and particularly has an obvious inhibitory effect on depression associated with monoamine oxidase A (MAO-A). The invention also provides the application of the pepper extract in preparing antidepressant drugs.

Description

technical field [0001] The invention relates to a Zanthoxylum bungeanum extract and its application, belonging to the field of medicine. Background technique [0002] Depression is an important public health problem. It is an affective mental disorder, manifested as persistent depression or grief, loss of interest in daily life, listlessness, loss of appetite and sleep disturbance, etc. Harm. The mechanism of depression is still not fully understood. Studies have found that depression is associated with genetic, psychological, neurological, endocrine and other factors that induce a decrease in the content of neurotransmitters such as norepinephrine (NE) or (and) 5-hydroxytryptamine (5-HT), dopamine (DA) and neuropeptides in the central nervous system. associated with decreased function of its receptors. In recent years, it has also been found to be related to hypothalamus-pituitary-adrenal axis negative feedback disorder, glutamate conduction disorder, neuroimmune abnorm...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61P25/24A61K125/00A61K127/00A61K135/00A61K131/00
Inventor 邹忠梅陈佳欢张涛张宏武
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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