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Application of lycium ruthenicum seed oil extracts in hypolipidemic medicines

A blood lipid-lowering drug, black fruit wolfberry technology, applied in the biological field, to achieve a clear mechanism of action, clear targets, and significant effects

Inactive Publication Date: 2019-07-05
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there has been no public report on the application of Lycium barbarum seed oil extract as a blood lipid-lowering drug

Method used

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  • Application of lycium ruthenicum seed oil extracts in hypolipidemic medicines
  • Application of lycium ruthenicum seed oil extracts in hypolipidemic medicines
  • Application of lycium ruthenicum seed oil extracts in hypolipidemic medicines

Examples

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Effect test

Embodiment 1

[0025] Application of an extract of Lycium barbarum seed oil in blood lipid-lowering medicine.

[0026] Firstly, a blood lipid-lowering drug containing fatty acid and sterol active ingredients of Lycium barbarum seed oil extract was prepared:

[0027] The fatty acid and sterol of the Lycium barbarum seed oil extract are prepared into a soft capsule preparation capable of lowering blood fat with an added amount of 80%. The specific preparation method is: mix 80 parts of black wolfberry seed oil, 10 parts of DHA and 10 parts of vitamin E evenly to make the soft capsule content material, and then press the soft capsule content material and soft capsule shell material on the pressing equipment for capsule processing Made into soft capsules of wolfberry seed oil.

Embodiment 2

[0029] The invention discloses an application of the black fruit Lycium barbarum seed oil extract in blood lipid-lowering medicine.

[0030] (1) Experiment description

[0031] The methods used in the following experiments are conventional methods unless otherwise specified.

[0032] Materials and reagents used in the following experiments can be obtained from commercial sources unless otherwise specified.

[0033] The specific preparation method of the fatty acid and sterol of the black fruit Lycium barbarum seed oil extract of the present invention used in following experiment is: the dried black fruit Lycium barbarum seed is pulverized and weighed, then charged in a supercritical extraction device (Jiangsu In the extraction kettle of Nantong Huaan Supercritical Extraction Co., Ltd., HA221-50-06 type), the supercritical extraction temperature was set at 40°C, the extraction pressure was 35 MPa, the carbon dioxide flow rate was 40 kg / h, and the extraction time was 90 min . ...

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Abstract

The invention relates to the technical field of biology, in particular to an application of lycium ruthenicum seed oil extracts in hypolipidemic medicines. The lycium ruthenicum seed oil extract fattyacid and sterol can be used as effective components to be prepared into hypolipidemic medicinal preparations with any pharmaceutically-acceptable carrier according to a conventional method. The lycium ruthenicum seed oil extract fatty acid and sterol can obviously inhibit the activity of pancrelipase and cholesterol esterase targets related to hyperlipidemia. Besides, zebrafish and mouse experiments prove that the lycium ruthenicum seed oil fatty acid and sterol have obvious blood fat-reducing effect; and the lycium ruthenicum seed oil fatty acid and sterol are used as active components for reducing blood fat, have good effect of reducing blood fat, have obvious effect, clear action mechanism and clear targets, and meet the requirement of development of pharmaceutical preparations.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the application of a black fruit wolfberry seed oil extract in blood lipid-lowering drugs. Background technique [0002] Hyperlipidemia refers to excessively high levels of TC or TG and their related lipoproteins in the blood, or low serum high-density lipoprotein cholesterol. Hyperlipidemia is associated with various diseases such as hypertension, coronary heart disease, stroke, and diabetes. Atherosclerosis caused by hyperlipidemia is the main cause of cardiovascular and cerebrovascular diseases such as coronary heart disease, myocardial infarction, cerebral hemorrhage, and cerebral infarction. Currently, the lipid-lowering drugs on the market mainly include statins, fibrates, Nicotinic acid, etc. Statins are typical hydroxymethylglutarphthalein coenzyme reductase inhibitors, which have significant curative effect, but are expensive and have potential side effects such as liver t...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61P3/06A61K131/00
CPCA61K36/815A61P3/06
Inventor 岳会兰赵晓辉邵赟梅丽娟陶燕铎党军刘增根
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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