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Injection parecoxib sodium medicinal composition for preemptive analgesia and preparing method thereof

A technology of parecoxib sodium and parebib sodium, which is applied in the field of injection medicine, and can solve the problem of not being able to eliminate the adverse reactions of opioid analgesics, not being able to reduce the dosage of opioid analgesics, and having no clear administration instructions and other issues, to achieve the effects of avoiding adverse events, good analgesic effect, and wide applicability

Inactive Publication Date: 2019-07-09
NANJING CHIA TAI TIANQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For the above combined medication methods, the dosage of parecoxib sodium and opioid analgesic drugs is mostly used in conventional dosages, which cannot reduce the dosage of opioid analgesic drugs, and cannot well eliminate the adverse reactions of opioid analgesic drugs; or In terms of reducing the dosage of opioid analgesics, it is mostly based on experience, and there is no clear dosing guidance
Using two medications at the same time adds a certain degree of risk and difficulty to the operation

Method used

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  • Injection parecoxib sodium medicinal composition for preemptive analgesia and preparing method thereof
  • Injection parecoxib sodium medicinal composition for preemptive analgesia and preparing method thereof
  • Injection parecoxib sodium medicinal composition for preemptive analgesia and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The pharmaceutical composition of Paribib sodium for injection used for preemptive analgesia of the present invention is prepared from the following components in every 1000 bottles:

[0032]

[0033] The preparation method of this pharmaceutical composition is as follows:

[0034] (1) Dosing:

[0035] ① Dissolve fructose in 20%-22% water for injection according to the proportion of the components, add medicinal activated carbon, mix and stir, filter, then add sufentanil and stir to dissolve, adjust the pH value to 8.0-8.5 to obtain solution I;

[0036] ② Take 68%-70% water for injection according to the proportion of the group, add glycine and anhydrous disodium hydrogen phosphate, stir and dissolve, then add parecoxib sodium, after completely dissolving, adjust the pH value to 8.0-8.5 to obtain a solution II;

[0037] ③ Combine solution I and solution II, add water for injection to the total amount, stir evenly, filter through a microporous membrane, pour into in...

Embodiment 2

[0044] The pharmaceutical composition of Paribib sodium for injection used for preemptive analgesia of the present invention is prepared from the following components in every 1000 bottles:

[0045]

[0046] The preparation method is the same as in Example 1.

Embodiment 3

[0048] The pharmaceutical composition of Paribib sodium for injection used for preemptive analgesia of the present invention is prepared from the following components in every 1000 bottles:

[0049]

[0050] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses an injection parecoxib sodium medicinal composition for preemptive analgesia and a preparing method thereof. The medicinal composition is prepared from, by weight, 15-20 partsof parecoxib sodium and 0.02-0.04 part of sufentanil. According to the injection parecoxib sodium medicinal composition, through the combined use of the parecoxib sodium and the sufentanil, advanced drug administration is conducted, the dosage of the sufentanil can be effectively lowered, and thus untoward effects of opioid analgesia drugs are reduced; meanwhile, the best analgesia effect is achieved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a combined injection of parecoxib sodium and sufentanil. Background technique [0002] At present, the drugs that can exert analgesic effect clinically mainly include narcotic analgesics and non-narcotic analgesics. Narcotic analgesics, also known as opioid analgesics, can act on the opioid receptors in the central nervous system to relieve the pain of patients, but it is easy to bring adverse reactions such as nausea, vomiting, constipation, respiratory depression and hyperalgesia to patients , increasing the difficulty of postoperative rehabilitation. Non-narcotic analgesics (NSAIDs) are mainly represented by non-steroidal anti-inflammatory analgesics, which can selectively inhibit COX-2, reduce the production of prostaglandins and exert antipyretic, analgesic and anti-inflammatory effects. It can excite or weakly excite opioid receptors, and avoid the adverse react...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4535A61K9/19A61K47/10A61K47/18A61K47/26A61P29/00A61K31/42
CPCA61K31/42A61K31/4535A61K9/0019A61K9/19A61K47/26A61K47/183A61K47/10A61P29/00A61K2300/00
Inventor 王贞宋忠进
Owner NANJING CHIA TAI TIANQING PHARMA
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