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A detection device and application of a variety of basic drugs of abuse in degraded biological samples

A technology for abusing drugs and biological testing materials, which is applied in the preparation of test samples, measuring devices, material separation, etc., and can solve the problems that affect the inspection effect, difficult to master the processing of test materials, and oxidation of test materials

Inactive Publication Date: 2021-09-14
HAINAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the degraded corpse, there are more cadaverine in the organs, which makes the pH value in the corpse alkaline, and the longer the decomposition time, the stronger the alkalinity of the organs in the corpse, and, for some alkaline substances that need to be detected Substances are easier to be hidden, especially for some abused drug solutions, which are extremely oxidizing. If exposed to sunlight, rapid oxidation will occur, resulting in inaccurate detection results. Most of the existing processing methods are in the dark detection room. Separate various testing equipment for distributed processing of test materials, which will cause part of the oxidation of the test materials during the movement process, and the room is dark, making it difficult to grasp the processing of test materials, which will also affect the effect of the test

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  • A detection device and application of a variety of basic drugs of abuse in degraded biological samples
  • A detection device and application of a variety of basic drugs of abuse in degraded biological samples
  • A detection device and application of a variety of basic drugs of abuse in degraded biological samples

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Embodiment 1

[0042] see Figure 1-9 , according to an embodiment of the present invention, a detection device for degrading a variety of basic drugs of abuse in biological specimens, including a crushing mechanism 1, a buffer injection mechanism 2, an ultrasonic treatment mechanism 3, an oscillating centrifugal mechanism 4, an extraction mechanism 5, an evaporation Mechanism 6, heat dissipation mechanism 7 and chromatography mass spectrometer 8, wherein, the crushing mechanism 1, buffer injection mechanism 2, ultrasonic treatment mechanism 3, vibration centrifugal mechanism 4, extraction mechanism 5, evaporation mechanism 6, heat dissipation mechanism 7 and chromatography mass spectrometer A moving plate 9 runs through the instrument 8, and a chute 10 is arranged under the moving plate 9, and the chute 10 is fixed on the crushing mechanism 1, the buffer injection mechanism 2, the ultrasonic treatment mechanism 3, and the vibration centrifugal mechanism. 4. On the extraction mechanism 5, th...

Embodiment 2

[0045] see figure 1 and image 3 , for the holding dish 16, the outer wall of the holding dish 16 is provided with a pressing mechanism, and the pressing mechanism includes several springs 39, and one end of the spring 39 is fixed on the inner wall of the holding cylinder 15 , the other end of the spring 39 is fixed on the resisting plate 40, and the resisting plate 40 is in contact with the containing cylinder 15 through an arc-shaped sliding plate. The storage vessel 16 can be resisted by the spring 39, reducing the gap between the storage vessel 16 and the storage cylinder 15. A number of rollers 41 are arranged under the storage cylinder 15, and the storage cylinder 15 passes through the rollers. 41 is in contact with the bearing plate 19 . So that the holding cylinder 15 can be filled with potassium dihydrogen phosphate buffer solution in the buffer storage bin 31, the pH value of the potassium dihydrogen phosphate buffer solution is 6.0, it is worth noting that the pot...

Embodiment 3

[0047] see Figure 4 and Figure 10 , for the ultrasonic treatment mechanism 3, the ultrasonic treatment mechanism 3 includes a third box, the inner wall of the third box is provided with an ultrasonic generator 42, and the ultrasonic generator 42 is connected to the controller 38 for control. It is worth noting that the ultrasonic treatment time mentioned here is 15 minutes, and the vibration centrifugal mechanism 4 includes a fourth box body, and the inner wall of the fourth box body is fixedly provided with an ultrasonic oscillator 43. A third rotating motor 44 is provided, the output end of the third rotating motor 44 is provided with a second extension rod 45, the cross section of the second extension rod 45 is square, and the second extension rod 45 is covered with a second A square tube 46, the second square tube 46 matches the square hole 20, a third telescopic mechanism 47 is provided on one side of the second square tube 46, the ultrasonic oscillator 43 and the thir...

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Abstract

The invention discloses a detection device and application for degrading a variety of basic drugs of abuse in bio-test materials, including a crushing mechanism, a buffer injection mechanism, an ultrasonic treatment mechanism, an oscillating centrifugal mechanism, an extraction mechanism, an evaporation mechanism, a heat dissipation mechanism and a hue Mass spectrometer, wherein, a moving plate runs through between the crushing mechanism, the buffer injection mechanism, the ultrasonic treatment mechanism, the oscillating centrifugal mechanism, the extraction mechanism, the evaporation mechanism, the heat dissipation mechanism and the chromatographic mass spectrometer, and the moving plate is provided with A chute, the chute is fixed on the crushing mechanism, the buffer injection mechanism, the ultrasonic treatment mechanism, the vibration centrifugal mechanism, the extraction mechanism, the evaporation mechanism, the heat dissipation mechanism and the color phase mass spectrometer. Beneficial effects of the present invention: by soaking the test material in a buffer solution after crushing, the effect of cadaverine on alkalinization of the pH value in the corpse can be effectively reduced, thereby accurately detecting the amount of drugs of abuse.

Description

technical field [0001] The field of detection of biological samples of the present invention, specifically, relates to a detection device and application for degrading various basic drugs of abuse in biological samples. Background technique [0002] At present, the problem of drug abuse in my country is developing and spreading, and a situation of cross-abuse of transmission drugs, new drugs, narcotic drugs, and psychotropic substances has formed. For biodegradation, biodegradation means that the material is continuously discharged from the body during the process of tissue growth through dissolution, enzymatic hydrolysis, and phagocytosis in the organism, and the repaired tissue completely replaces the position of the implanted material. The material does not have residual properties in the body. [0003] In the degraded corpse, there are more cadaverine in the organs, which makes the pH value in the corpse alkaline, and the longer the decomposition time, the stronger the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06G01N30/02G01N1/28G01N1/30
CPCG01N1/286G01N1/30G01N30/02G01N30/06
Inventor 范浩亮邱平明赵凯王骁陶乐居王鑫
Owner HAINAN MEDICAL UNIV
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