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Tyrosine derivatives and compositions comprising them

A composition and tyrosine technology, applied in the field of compositions for reducing cell proliferation, can solve the problems of expensive and imprecise treatment methods

Pending Publication Date: 2019-07-26
TYME
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] While all of these treatments are effective to some degree, they all have drawbacks and limitations
In addition to many treatments being expensive, they are often too imprecise or the cancer can adapt to them and become resistant

Method used

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  • Tyrosine derivatives and compositions comprising them
  • Tyrosine derivatives and compositions comprising them

Examples

Experimental program
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Effect test

Embodiment 1

[0085] The following study proved the ability of the tyrosine hydroxylase part of the above composition to be incorporated into pancreatic cells.

[0086] Background: SM88 is a new combination of five treatments (sirolimus, melanin, melanotan, phenytoin, and tyrosine isomers). When administered together, it has been shown to have in a preliminary study of 30 patients Almost no toxic to no toxic anti-cancer activity [J Clin Oncol 31, 2013 (Supplement; Abstract e22095) and Hoffman et al., GynOncol, 130(1), e43]. The study reported preclinical animal data related to the toxicity of the tyrosine agent α-methyl-DL-tyrosine, and the possible mechanism of action.

[0087] Materials and methods: A pre-clinical animal model for toxicological studies of 7-day escalation and 28-day repeated administration in Sprague Dawley rats and beagledogs using α-methyl-DL-tyrosine. At dose levels of 25, 75, 150 and 300 mg / kg, the test and control / vehicle articles were administered once a day or three ti...

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Abstract

Compositions and kits comprising a tyrosine hydroxylase inhibitor and an anticancer agent that is chemically bonded to, or physically associated with, the tyrosine hydroxylase inhibitor are provided.Also provided are methods for reducing cell proliferation in a subject comprising administering to a subject in need thereof a composition comprising a tyrosine hydroxylase inhibitor and an anticanceragent that is chemically bonded to, or physically associated with, the tyrosine hydroxylase inhibitor.

Description

Technical field [0001] The present invention generally relates to compositions, kits and methods for reducing cell proliferation as, for example, in cancer treatment. Background technique [0002] According to the 2008 Surveillance Epidemiology and End Result (SEER) database of the US National Cancer Institute, 11,958,000 Americans in the most recent year for which incidence data are available Suffer from aggressive cancer. Cancer is the second most common cause of death in the United States, after heart disease, and accounts for a quarter of deaths. It is estimated that about 1,600 Americans die from cancer every day. In addition to the medical, emotional, and psychological costs of cancer, cancer has huge economic costs to both individuals and society. According to the National Institutes of Health, the total cost of cancer in 2010 was $263.8 billion. In addition, it is estimated that due to premature deaths, another 140.1 billion US dollars in productivity was lost. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/195A61P35/00
CPCA61K45/06A61K31/195A61P35/00A61K2300/00A61K31/198
Inventor 史蒂文·霍夫曼
Owner TYME
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