Tyrosine hydroxylase inhibitors for treatment of intestinal hyperpermeability
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A tyrosine hydroxylase inhibitor, a technology of tyrosine hydroxylase, which is applied in the directions of non-central analgesics, anhydride/acid/halide active ingredients, and non-active ingredients medical preparations, etc. Proven safe and effective
Pending Publication Date: 2022-01-07
史蒂文霍夫曼
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Several drug targets that could potentially promote barrier restoration have been proposed, but none have been proven safe and effective
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Embodiment 1
[0043] Initially 200 patients were screened. Thirty subjects who met the study criteria consented. Nine (9) subjects had high blood sugar levels (hyperglycemia) prior to consent to the study.
[0044]High blood glucose levels (hyperglycemia) were defined as fasting plasma glucose levels of 126 mg / dl or greater on two separate occasions. The mean patient age was 62 years, and the median patient age was 60 years. Six patients were female and three patients were male. Five patients were 50-60 years old, and 4 patients were over 60 years old.
[0045] Patients in the study were administered drugs including tyrosine hydroxylase inhibitors (i.e., α-methyl-DL tyrosine), melanin boosters (i.e., melanotan II), p450 3A4 boosters (i.e., 5 , 5-diphenylhydantoin) and leucine aminopeptidase inhibitors (ie, N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutyryl]-L- leucine) treatment options. The compounds were administered each of 5 days per week for a period of 6 weeks with 1 or 2 days of rest...
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Abstract
The invention relates to tyrosine hydroxylase inhibitors for the treatment of intestinal hyperpermeability, and provides methods, compositions and kits for the treatment of intestinal hyperpermeability in a subject in need thereof, the intestinal hyperpermeability includes conditions such as hyperglycemia and conditions such as diabetes, autism, fibromyalgia, inflammatory bowel disease (IBD), graft versus host disease (GVHD), HIV / AIDS, multiple organ dysfunction syndrome, irritable bowel syndrome (IBS), celiac disease, eczema, psoriasis, acute pancreatitis, Parkinson's disease, depression, chronic fatigue syndrome, asthma, multiple sclerosis, arthritis, and the like. The medicine can be used for treating basic diseases such as ankylosing spondylitis, non-alcoholic fatty liver disease, alcoholic cirrhosis, environmental intestinal lesion or malignant dystrophy.
Description
[0001] This application is a divisional application of a Chinese patent application with an application date of October 21, 2014, an application number of 201480058279.7, and an invention title of "tyrosine hydroxylase inhibitor for the treatment of intestinal hyperpermeability". [0002] Cross References to Related Applications [0003] This application claims the benefit of U.S. Patent Application No. 14 / 062,165, filed October 24, 2013, which claims the benefit of U.S. Patent Application No. 61 / 894,261, filed October 22, 2013, the entire contents of both are hereby incorporated by reference Incorporated into this article. technical field [0004] The present invention generally relates to compositions, kits and methods for treating intestinal hyperpermeability. Background technique [0005] The intestinal epithelium separates the luminal contents from the interstitium. This function is largely dependent on the integrity of the epithelium and the tight junctions that sea...
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