Application of glaucocalyxin A in preparation of drug for treating lung cancer

A technology of Wangzaozi B and its uses, which is applied in the fields of biochemistry and molecular biology, can solve the problems of complex pathological mechanisms and have not been clearly explained, and achieve the effect of promoting expression

Inactive Publication Date: 2019-07-30
DALIAN UNIV OF TECH
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

NSCLC is the most common form of lung cancer and has complex pat

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of glaucocalyxin A in preparation of drug for treating lung cancer
  • Application of glaucocalyxin A in preparation of drug for treating lung cancer
  • Application of glaucocalyxin A in preparation of drug for treating lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0025] Example: Extraction and verification of Wangzaozi B

[0026] Refer to CN105585471A to extract and verify Wangzaozi B. Briefly, the extraction steps are as follows: (1) Wangzaozi roots are crushed with an ordinary grinder, and the Wangzaozi root powder is obtained through a 40-mesh sieve; (2) Wangzaozi roots are accurately weighed 5.0kg coarse powder, add 60g NaHCO 3 The additives are mixed uniformly. After grinding in the super mill for 40 minutes, pass through a 300-mesh sieve, accurately weigh 2.0kg and place in a beaker, add 80% ethanol aqueous solution according to the material-to-liquid ratio of 1:24, and stir evenly; (3 ) Ultrasonic extraction for 50 min under ultrasonic conditions of 45°C, frequency 43kHz and power 250W, the extract is vacuum filtered to obtain the filtrate, which is concentrated under reduced pressure at 40°C and 60r / min to obtain a concentrated solution; (4) Concentrates in turn Extract with petroleum ether and chloroform; (5) Take the chloroform ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses application of glaucocalyxin A in preparation of a drug for treating lung cancer. Particularly, the glaucocalyxin A acts on lung cancer cells, cell apoptosis can be induced bydestroying mitochondrial membrane potential, causing Cyto-C outflow, inhibiting anti-apoptosis protein Bcl-2, promoting pro-apoptotic protein Bax expression and causing Caspase cascade reactions, anda choice of a new treatment drug is provided for lung cancer treatment.

Description

technical field [0001] The invention belongs to the technical field of biochemistry and molecular biology, and specifically relates to the use of wangzaozi B in the preparation of medicines for treating lung cancer. Background technique [0002] Lung cancer (lung cancer, LC) is called primary bronchial carcinoma. It is a disease that is deficient in the whole body and true in the local area. It originates from the malignant tumor of the bronchial mucosa or glands. The five-year survival rate of lung cancer is extremely low, and its morbidity and mortality rank first in my country. [0003] According to the degree of differentiation and morphological characteristics of lung cancer, lung cancer is divided into two categories: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), and NSCLC includes squamous cell carcinoma and adenocarcinoma and large cell carcinoma. SCLC is a highly aggressive neuroendocrine tumor characterized by early metastasis, rapid progr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/122A61P35/00
CPCA61K31/122A61P35/00
Inventor 薛宏宇连显会苗诗雨牛蕾王宁周玉荣刘亚军姜丽丽刘勇
Owner DALIAN UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap