Application of murabutide in the preparation of drugs for the prevention and treatment of bone marrow, small intestine and spleen damage caused by ionizing radiation

A technology of ionizing radiation and drugs, applied in the prevention and treatment of small intestine and spleen damage, to prepare the field of bone marrow induced by ionizing radiation, to achieve low toxic and side effects, broad development and application prospects, and obvious effects

Active Publication Date: 2021-06-29
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are no related reports on the prevention and treatment effect of NOD2 agonist MBD on bone marrow, small intestine and spleen injury caused by acute whole body radiation

Method used

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  • Application of murabutide in the preparation of drugs for the prevention and treatment of bone marrow, small intestine and spleen damage caused by ionizing radiation
  • Application of murabutide in the preparation of drugs for the prevention and treatment of bone marrow, small intestine and spleen damage caused by ionizing radiation
  • Application of murabutide in the preparation of drugs for the prevention and treatment of bone marrow, small intestine and spleen damage caused by ionizing radiation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Firstly, a mouse model of ionizing radiation-induced systemic injury was established, and 30 8-week-old male C57BL / 6 mice were randomly divided into three groups: 10 mice in the control group, 10 mice in the irradiation group, and the pre-irradiation MBD administration group (7Gy+MBD) 10 pieces, use 60 The whole body of mice was irradiated with Coγ-rays once, and the absorbed dose of mice was 7Gy. MBD (15mg / kg MBD+0.2mL PBS / rat) or PBS (0.2mL / rat) were administered 2 hours before irradiation by intraperitoneal injection. The mice (control group, irradiation group and pre-irradiation MBD administration group) were regularly observed and recorded for 30 days after irradiation. like figure 1 As shown, from 7 days after irradiation, the mice in the irradiation group began to die, and appeared thin and decreased appetite, while the death time of the MBD treatment group before irradiation was significantly delayed. Based on the above, MBD pretreatment can significantly pro...

Embodiment 2

[0045] (1) Establishing a mouse model of ionizing radiation-induced systemic injury is the same as in Example 1;

[0046] (2) The grouping of mice, the way of administration and the way of irradiation were the same as in Example 1, and the mice were sacrificed at different time points (0 day, 1 day, 3 days) after irradiation, and the femur tissue, small intestine tissue and spleen tissue were taken and carried out. After fixing, embedding in wax blocks, HE staining was performed after sectioning. The HE results of femur tissue are as follows: figure 2 As shown, compared with the irradiation control group, the bone marrow cavity of the irradiation group was obviously empty, and the number of nucleated cells decreased, suggesting that the hematopoietic cells decreased; while the bone marrow cavity of the mice treated with MBD before irradiation (irradiation + MBD group) was relatively full, and at a certain To a certain extent, the reduction of hematopoietic cells and the inhi...

Embodiment 3

[0048] (1) Establishing a mouse model of ionizing radiation-induced systemic injury is the same as in Example 1;

[0049] (2) The wax blocks of the small intestine and spleen of each group of mice in Example 2 were taken one day after irradiation, and were sectioned for TUNEL staining. The number of TUNEL-positive cells was used to illustrate the apoptosis after irradiation. like Figure 5 As shown, the number of apoptotic cells in the non-irradiated group in the small intestine and spleen is very small, which is the expression of normal cell metabolism and apoptosis. The number of TUNEL-positive cells in the irradiation group increased significantly after irradiation, while MBD pretreatment before irradiation could significantly reduce the apoptosis induced by irradiation.

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Abstract

The invention relates to the field of new applications of medicines, in particular to the application of murabutide in the preparation of medicines for the prevention and treatment of bone marrow, small intestine and spleen damage caused by ionizing radiation. The murabutide provided by the invention has the advantages of low toxic and side effects, obvious prevention and treatment effect on radiation-sensitive organ damage, and the like as a medicine for preventing and treating bone marrow, small intestine, and spleen damage caused by ionizing radiation. It shows the unique advantages of murabutide in the prevention and treatment of multiple radiation-sensitive organ damage caused by ionizing radiation, and the purpose is to explore more efficient and low-toxicity treatment methods for the prevention and treatment of ionizing radiation damage; at present, there is still a lack of effective prevention and treatment of multiple organ damage caused by ionizing radiation at home and abroad Technical means are also one of the key problems that urgently need to be studied and solved in the field of radiology and clinical radiotherapy. Therefore, murabutide has broad development and application prospects in the field of medicine in my country as a drug for the prevention and treatment of multiple organ damage caused by ionizing radiation.

Description

technical field [0001] The invention relates to the field of new application of medicines, in particular to the application of murabutide in the preparation of medicines for the prevention and treatment of bone marrow, small intestine and spleen damage caused by ionizing radiation. Background technique [0002] With the rapid development of science and technology, nuclear energy has increasingly become an important part of the scientific research and military forces of various countries. Although nuclear energy management has been improved day by day, the possibility of serious accidents in nuclear power plants and the leakage of a large amount of radioactive materials still exists. According to incomplete statistics, there were 2007 radioactive accidents in my country from 1954 to 2015, with an average of more than 20 accidents per year. Moreover, radiotherapy, as an important auxiliary means of clinical malignant tumor treatment, will inevitably kill malignant tumor tissues...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/05A61P39/00
CPCA61K38/05A61P39/00
Inventor 刘蕾蔡建明高福杨彦勇曲红金崔建国廖泽彬曹堃陈媛媛刘哲
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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