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Application of Murabutide to preparation of medicine for preventing and treating bone marrow, small intestine and spleen injury caused by ionization radiation

An ionizing radiation, drug technology, applied in the direction of drug combination, antidote, dipeptide components, etc., to achieve the effect of obvious effect, low toxicity and side effects, and broad research prospects

Active Publication Date: 2019-08-02
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are no related reports on the prevention and treatment effect of NOD2 agonist MBD on bone marrow, small intestine and spleen injury caused by acute whole body radiation

Method used

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  • Application of Murabutide to preparation of medicine for preventing and treating bone marrow, small intestine and spleen injury caused by ionization radiation
  • Application of Murabutide to preparation of medicine for preventing and treating bone marrow, small intestine and spleen injury caused by ionization radiation
  • Application of Murabutide to preparation of medicine for preventing and treating bone marrow, small intestine and spleen injury caused by ionization radiation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Firstly, a mouse model of ionizing radiation-induced systemic injury was established, and 30 8-week-old male C57BL / 6 mice were randomly divided into three groups: 10 mice in the control group, 10 mice in the irradiation group, and the pre-irradiation MBD administration group (7Gy+MBD) 10 pieces, use 60 The whole body of mice was irradiated with Coγ-rays once, and the absorbed dose of mice was 7Gy. MBD (15mg / kg MBD+0.2mL PBS / rat) or PBS (0.2mL / rat) were administered 2 hours before irradiation by intraperitoneal injection. The mice (control group, irradiation group and pre-irradiation MBD administration group) were regularly observed and recorded for 30 days after irradiation. Such as figure 1 As shown, from 7 days after irradiation, the mice in the irradiation group began to die, and appeared thin and decreased appetite, while the death time of the MBD treatment group before irradiation was significantly delayed. Based on the above, MBD pretreatment can significantly ...

Embodiment 2

[0045] (1) Establishing a mouse model of ionizing radiation-induced systemic injury is the same as in Example 1;

[0046] (2) The grouping of mice, the way of administration and the way of irradiation were the same as in Example 1, and the mice were sacrificed at different time points (0 day, 1 day, 3 days) after irradiation, and the femur tissue, small intestine tissue and spleen tissue were taken and carried out. After fixing, embedding in wax blocks, HE staining was performed after sectioning. The HE results of femur tissue are as follows: figure 2 As shown, compared with the irradiation control group, the bone marrow cavity of the irradiation group was obviously empty, and the number of nucleated cells decreased, suggesting that the hematopoietic cells decreased; while the bone marrow cavity of the mice treated with MBD before irradiation (irradiation + MBD group) was relatively full, and at a certain To a certain extent, the reduction of hematopoietic cells and the inhi...

Embodiment 3

[0048] (1) Establishing a mouse model of ionizing radiation-induced systemic injury is the same as in Example 1;

[0049] (2) The wax blocks of the small intestine and spleen of each group of mice in Example 2 were taken one day after irradiation, and were sectioned for TUNEL staining. The number of TUNEL-positive cells was used to illustrate the apoptosis after irradiation. Such as Figure 5 As shown, the number of apoptotic cells in the non-irradiated group in the small intestine and spleen is very small, which is the expression of normal cell metabolism and apoptosis. The number of TUNEL-positive cells in the irradiation group increased significantly after irradiation, while MBD pretreatment before irradiation could significantly reduce the apoptosis induced by irradiation.

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Abstract

The invention relates to the field of a new purpose of medicine, in particular to application of Murabutide to preparation of medicine for preventing and treating bone marrow, small intestine and spleen injury caused by ionization radiation. When being used as the medicine for preventing and treating the bone marrow, small intestine and spleen injury caused by ionization radiation, the Murabutideprovided by the invention has the advantages of low toxic and side effects, obvious radiation sensitive organ injury prevention and treatment effects and the like. The unique advantages of the Murabutide in the prevention and treatment on multi-radiation sensitive organ injury caused by ionization radiation is shown; the invention aims at exploring an efficient and low-toxicity curing method for ionization radiation injury prevention and treatment. In the prior art, an effective prevention and treatment technological means is lacked for multiple organ injury caused by ionization radiation at home and abroad; the problem is also one of key difficult problems to be studied and solved in the fields of radioactive medicine and clinical radiotherapy. Therefore, when being used as the medicine for preventing and treating whole body multiple organ injury caused by ionization radiation, the Murabutide has wide development and application prospects in the medical field in China.

Description

technical field [0001] The invention relates to the field of new application of medicines, in particular to the application of murabutide in the preparation of medicines for the prevention and treatment of bone marrow, small intestine and spleen damage caused by ionizing radiation. Background technique [0002] With the rapid development of science and technology, nuclear energy has increasingly become an important part of the scientific research and military forces of various countries. Although nuclear energy management has been improved day by day, the possibility of serious accidents in nuclear power plants and the leakage of a large amount of radioactive materials still exists. According to incomplete statistics, there were 2007 radioactive accidents in my country from 1954 to 2015, with an average of more than 20 accidents per year. Moreover, radiotherapy, as an important auxiliary means of clinical malignant tumor treatment, will inevitably kill malignant tumor tissues...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61P39/00
CPCA61K38/05A61P39/00
Inventor 刘蕾蔡建明高福杨彦勇曲红金崔建国廖泽彬曹堃陈媛媛刘哲
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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