Method for improving chemical titer in antibiotic production

Abstract

The invention discloses a method for improving chemical titer in antibiotic production, and a safe, convenient and reasonable optimal operation scheme aiming at improving the overall chemical titer isprovided through a machine learning method. The method comprises the following steps: S10, establishing a production guidance model, wherein the production guidance model comprises an event element,a time period event chain, a full-cycle event chain and an event chain map; S20, learning non-fixed elements and production operation schemes corresponding to event chains in each time period in the event chain map; S30, generating a chemical valence distribution frequency table, recording the occurrence frequency of the event chain in the same time period and the chemical titer of each time, andcalculating the average chemical titer of the event chain in the time period; S40, determining a fixed element, a previous period event chain and a non-fixed element of the current fermentation, matching a period event chain which is the same as the current fermentation in an event chain map, and taking the non-fixed element of the period event chain of which the average chemical titer ranks the first and the production operation scheme as a production guidance scheme of the current fermentation.

Description

technical field

[0001] The invention relates to the technical field of production management, in particular to a method for increasing chemical potency in antibiotic production. Background technique

[0002] Chemical potency refers to the potency of antibiotics determined by chemical methods in the production of antibiotics. It represents the total content of the drug and is a measure of the active ingredients of the drug. It has a high specificity for antibiotics whose chemical structure has been determined. , and its improvement is conducive to increasing the output of the product.

[0003] The stable improvement of chemical potency is an important topic of general concern in the biopharmaceutical industry. The main difficulty lies in the fact that there are too many factors affecting the growth of microorganisms, there are many unknown or uncertain factors, and the potency is highly unpredictable. At present, the microbial fermentation stage in the field of biopharmaceut...