Composition for treating helicobacter pylori infection and preparation and application thereof

A Helicobacter pylori and composition technology, applied in the field of pharmaceutical compositions, can solve the problems of reducing the eradication rate of Helicobacter pylori, increasing the treatment cost of patients, and the high price of rifabutin, so as to reduce treatment costs, improve compliance, and treat The effect of cycle shortening

CN110354125AInactive Publication Date: 2019-10-22赛隆药业集团股份有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2019-10-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a composition for treating helicobacter pylori infection and a preparation and application thereof. The composition is prepared from, by weight, 10-20 parts of rifabutin, 70-120parts of amoxicillin and 2.2-4 parts of (-)-pantoprazole sodium; by adopting the composition, the treatment cycle of a second-line triple therapy can be shortened by 20%, and the treatment cost of apatient is reduced. The invention further provides a capsule used for treating helicobacter pylori infection. The capsule can improve the compliance of the patient, and therefore the rate of eradication for helicobacter pylori is increased.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical compositions, in particular to a composition for treating Helicobacter pylori infection and its preparation and application. Background technique

[0002] Helicobacter pylori (Hp) is a Gram-negative, microaerophilic bacterium that lives in the stomach and duodenum. It causes mild chronic inflammation of the gastric mucosa and can even lead to gastric and duodenal ulcers and gastric cancer. In my country, more than half of the population has Helicobacter pylori infection, eradicating Helicobacter pylori infection can cure gastritis and duodenal ulcer, and can prevent the occurrence of gastric cancer. The eradication regimen of H. pylori includes standard triple therapy, including proton pump inhibitors, amoxicillin, and clarithromycin. However, due to clarithromycin resistance, the eradication rate of standard triple therapy against H. pylori has dropped significantly to less than 80%. For patients ...

Examples

Embodiment 1

[0029] A composition for treating Helicobacter pylori infection, said composition comprising:

[0030] Rifabutin 150mg

[0031] Amoxicillin 1000mg

[0032] Levopantoprazole Sodium 27mg.

Embodiment 2

[0034] A composition for treating Helicobacter pylori infection, said composition comprising:

[0035] Rifabutin 100mg

[0036] Amoxicillin 700mg

[0037] Levopantoprazole Sodium 22mg.

Embodiment 3

[0039] A composition for treating Helicobacter pylori infection, said composition comprising:

[0040] Rifabutin 200mg

[0041] Amoxicillin 1200mg

[0042] Levopantoprazole Sodium 40mg.