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Compositions for the treatment of cardiovascular disease

A composition and plant technology, applied in cardiovascular system diseases, metabolic diseases, drug combinations, etc., can solve problems such as indigestion, increased fatty acid clearance, and decreased expression of apoC-III

Inactive Publication Date: 2019-11-29
NEILOS SRL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although niacin is a vitamin, when it is used at doses (>1000 mg / day), it is associated with multiple side effects, including itching and redness of the skin and indigestion, which limit its therapeutic application
[0015] Finally, a fifth class of drugs consists of fibrates that interact with the PPARα (peroxisome proliferator-activated protein-α) receptor, causing increased expression of lipoprotein lipase and decreased expression of apoC-III, which lead to increased clearance of fatty acids

Method used

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  • Compositions for the treatment of cardiovascular disease
  • Compositions for the treatment of cardiovascular disease
  • Compositions for the treatment of cardiovascular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0084] Below are some examples of formulations, and the daily doses of the relevant active substances.

Embodiment 1

[0087] active ingredient quantity Concentration by weight (based on total formulation) Phytosterols 800mg 20.00％ curcumin 100mg 2.50％ Proantho Cyanidins 80mg 2.00％ piperine 20mg 0.50％ Monacolin K 10mg 0.25％ coenzyme Q 10

Embodiment 2

[0089]

[0090]

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PUM

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Abstract

The invention relates to a synergistic composition of naturally occurring substances, which is particularly effective in the treatment of hypercholesterolemia. The composition of the invention comprises at least one substance having 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitory activity, a substance having cytochrome CYP7A1 expression increasing activity, a substance having inhibitoryactivity against the enzyme Acyl-CoA: cholesterol acyltransferase ACAT1 and ACAT2 isoforms, procyanidins, and optionally, coenzyme Q10 and phytosterols.

Description

technical field [0001] The present invention relates to a composition of substances, preferably obtained from natural sources, effective in the treatment of hypercholesterolemia and in the prevention of atherosclerotic plaque formation and cardiovascular diseases. Background technique [0002] Hypercholesterolemia is a dyslipidemia, a condition characterized by high blood cholesterol concentrations. Since cholesterol is not water soluble, it is transported in the blood by lipoproteins. Lipoproteins are classified according to their density into very low density lipoprotein (VLDL), low density lipoprotein (LDL), intermediate density lipoprotein (IDL) and high density lipoprotein (HDL). High plasma levels of cholesterol transported by non-HDL lipoproteins, especially LDL lipoproteins, are associated with increased risk of atherosclerosis and cardiovascular disease. In contrast, increased levels of HDL cholesterol are thought to be protective. [0003] Cardiovascular disease...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61K31/122A61K31/353A61K31/36A61K31/366A61K31/4525A61K31/568A61K31/575A61K31/7034A61K36/062A61K36/15A61K36/328A61K36/67A61K36/73A61K36/87
CPCA61K9/009A61K9/2009A61K9/2013A61K9/2054A61K31/12A61K31/122A61K31/353A61K31/36A61K31/366A61K31/4525A61K31/568A61K31/575A61K31/7034A61K36/062A61K36/15A61K36/328A61K36/67A61K36/73A61K36/87A61K36/899A61K36/9066A61K45/06A61K47/12A61K47/26A61P3/06A61P9/10A61K2300/00
Inventor U·迪迈奥
Owner NEILOS SRL
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