4-aminoantipyrine continuous production system

A technology for the production system of aminoantipyrine, which is applied in the field of continuous production system of 4-aminoantipyrine, can solve the problems of waste of manpower, non-continuous production, and low efficiency, so as to avoid manpower and material resources, improve Atomization effect, the effect of reducing energy consumption

Active Publication Date: 2019-12-03
QINGDAO UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing production system is batch type, and the next reaction can only be carried out after the reaction between antipyrine and sodium nitrite in the nitrosation reactor, the production cannot be continuous, the efficiency is low, and a lot of manpower is wasted

Method used

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  • 4-aminoantipyrine continuous production system

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Embodiment

[0024] Such as figure 1 As shown, a 4-aminoantipyrine continuous production system includes antipyrine sulfuric acid solution storage tank 1, sodium nitrite solution storage tank 2, N 2 Storage tank 3, impinging stream reactor 4, reducing agent storage tank 5, first buffer tank 6, second buffer tank 7, compressor 8, reduction reactor 9, hydrolysis tank 10, neutralization tank 11, product storage tank 12 , Sulfuric acid storage tank 13, liquid ammonia storage tank 14, cold brine storage tank 15, cold brine recovery tank 16.

[0025] The impinging stream reactor 4 includes a straight cylindrical vessel body 41, an oval top cover 42, and a conical vessel bottom 43. The vessel body 41 is provided with an antipyrine sulfuric acid solution inlet and sodium nitrite arranged up and down. Solution inlet; the bottom of the bottom 43 is provided with a discharge port, and the top of the top cover 42 is provided with an exhaust port;

[0026] A first spray gun 12 is installed in the antipyrin...

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Abstract

The invention discloses a 4-aminoantipyrine continuous production system. The 4-aminoantipyrine continuous production system includes an antipyrine sulfuric acid solution storage tank, a sodium nitrite solution storage tank, an impinging stream reactor, a reducing agent storage tank, a reduction reaction kettle, a hydrolysis tank, a neutralization tank and a product storage tank, wherein a first spray gun is installed in an antipyrine sulfuric acid solution inlet of the impinging stream reactor, a second spray gun is installed in a sodium nitrite solution inlet, and an injector is installed ina reducing agent inlet; the antipyrine sulfuric acid solution storage tank is connected with the first spray gun, the sodium nitrite solution storage tank is connected with the second spray gun, andthe reducing agent storage tank is connected with the injector; and a material outlet in the impinging stream reactor is connected with the reduction reactor kettle, the hydrolysis tank, the neutralization tank and the product storage tank sequentially. The continuous production process of 4-aminoantipyrine has simple operation and easy monitor, extra manpower and material resources consumed by starting and stopping of intermittent production, and energy consumption is reduced.

Description

Technical field [0001] The present invention relates to the field of medicine and chemical industry, in particular to a continuous production system of 4-aminoantipyrine. Background technique [0002] my country is the country with the largest export volume of Analgin in the world. As an important antipyretic and analgesic drug, the market demand for Analgin is very large. 4-aminoantipyrine is used as an intermediate for the production of Analgin. The amount used is also large, so it is particularly important to study a 4-aminoantipyrine production system that is convenient to operate, high in production efficiency, and safe. [0003] The traditional production method of 4-aminoantipyrine is: antipyrine is nitrosated by sodium nitrite, then reduced by ammonium bisulfite and ammonium sulfite, then hydrolyzed by sulfuric acid and finally neutralized by liquid ammonia to obtain 4- Aminoantipyrine. The existing production system is batch type, and the next step reaction can be carried...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D231/46
CPCC07D231/46
Inventor 张俊梅段振亚李文辰王磊王子福
Owner QINGDAO UNIV OF SCI & TECH
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