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An antimicrobial composition

An antimicrobial, composition technology, applied in the field of hair care composition, personal care composition, hair and scalp cleansing composition

Active Publication Date: 2019-12-06
UNILEVER IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This indicates that most of the zinc pyrithione is oxidized and is no longer effective as a biocide

Method used

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  • An antimicrobial composition
  • An antimicrobial composition
  • An antimicrobial composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1 to 5

[0082] The synergistic interaction between ZPTO and AML compounds against Malassezia furfur was determined using the ΣFIC assay. A brief description of the method is given below.

[0083] Method: Determination by ΣFIC method against Malassezia furfur

[0084] Microbial preparation:

[0085] Malassezia furfur (CBS 1878) maintained on MD agar plates (solution A) were cultured into 20 ml of growth medium Pityrosporum Broth (PB, solution B).

[0086] Solution A preparation

[0087] Modified Dixon Agar (MD)

[0088]

[0089]

[0090] Deionized water to 1000ml

[0091] 50mg (1 vial) dissolved in 2ml 95% ethanol Chloramphenicol (Oxoid SR078E)

[0092] (make sure to stir thoroughly, including after autoclaving)

[0093] Solution B preparation

[0094] Pityrosporum Broth (PB)

[0095]

[0096] Adjust the pH to 6.2

[0097] After sterilization

[0098] 0.5ml UHT milk

[0099] They were then incubated for 48 hours at 32°C with shaking. Then, 1 ml of the first bro...

Embodiment 6-10

[0127] Embodiment 6-10: The antibacterial efficacy of the combinations claimed in the present invention was determined using the ΣFIC assay against Staphylococcus aureus. Sphingosine was also tested against triclosan and triclocarban. A brief description of the method is given below.

[0128] Method: ∑FIC method for detection and determination of Staphylococcus aureus

[0129] Microbial preparation:

[0130] Staphylococcus aureus (ATCC 12600) was streaked on Tryptone Soy Agar plates (TSA, solution C) and individual colonies were grown into 20 ml of the growth medium Tryptone Soy Broth (TSB, solution D).

[0131] Preparation of Solution C (Tryptone Soy Agar, TSA)

[0132] 40g Tryptone Soy Agar (Oxoid)

[0133] Deionized water to 1000ml

[0134] autoclave

[0135] Solution D Preparation (Tryptone Soy Broth, TSB)

[0136] 30g tryptone soy broth

[0137] Deionized water to 1000ml

[0138] autoclave

[0139] They were then incubated overnight (16 hours) at 37°C with...

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PUM

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Abstract

This invention relates to an antimicrobial composition, especially one which provides synergistic anti-dandruff efficacy. This is achieved through a judicious combination of anti-dandruff agent zinc pyrithione and selected antimicrobial lipids. These compositions can be delivered through shampoo or conditioner. Disclosed is an anti-microbial composition comprising: (i) 0.1 to 3% by weight of zincpyrithione; (ii) 0.01 to 5.0% by weight of an antimicrobial lipid selected from sapienic acid, palmitoleic acid, sphingosine, dihydrosphingosine, and phytosphingosine; and a cosmetically acceptable vehicle, wherein said composition is a shampoo or a conditioner for preventing or alleviating the symptoms of dandruff on the scalp and / or hair and where an antimicrobial alcohol having 1 to 7 carbon atoms are absent from the composition.

Description

technical field [0001] The present invention relates to antimicrobial compositions. The present invention more particularly relates to personal care compositions, such as compositions for hair care, which provide antimicrobial benefits. More particularly to cleansing compositions for hair and scalp comprising actives that interact to provide synergistic antimicrobial efficacy for anti-dandruff benefits. Background technique [0002] The present invention relates to antimicrobial compositions which can be used for cleansing any part of the body, but are particularly suitable for use on the hair and scalp. Hair care compositions generally provide cleansing or conditioning benefits or a combination of both. Such compositions generally comprise one or more cleansing surfactants, which generally help to clean the hair and / or scalp free of undesirable dirt, particulate and fatty matter. [0003] Additionally, anti-dandruff benefits have been provided by hair care compositions. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/36A61K8/41A61Q5/00A61Q5/02A61Q5/10A61Q17/00A61Q19/10A61Q5/12A61P17/10A61K31/133A61K31/201A61K8/27A61K8/49
CPCA61K8/27A61K8/361A61K8/41A61K8/4933A61Q5/006A61Q5/02A61Q5/12A61Q17/005A61Q19/10A61K31/133A61K31/201A61K2800/58A61P17/10
Inventor 朱崇净浦铭铭
Owner UNILEVER IP HLDG BV
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