Application of Interleukin 4 Receptor in Preparation of Drugs for Prevention and Treatment of Enterovirus 71 Infection

A technology of interleukin and enterovirus, applied to the new target and application field of anti-enterovirus 71 infection

Active Publication Date: 2021-10-15
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, there are no reports on the role of IL4R and FGFR1 molecules in enteroviruses, especially EV71-infected host cells. In-depth research on these two molecules will not only improve the understanding of EV71 infection and pathogenic mechanisms, but also provide Prevention and treatment of EV71 infection provides new ideas and targets

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Interleukin 4 Receptor in Preparation of Drugs for Prevention and Treatment of Enterovirus 71 Infection
  • Application of Interleukin 4 Receptor in Preparation of Drugs for Prevention and Treatment of Enterovirus 71 Infection
  • Application of Interleukin 4 Receptor in Preparation of Drugs for Prevention and Treatment of Enterovirus 71 Infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] 1 Design and synthesis of specific siRNA sequences for each transport-related membrane protein.

[0063] 1.1 For each target gene, search NCBI GeneBank to obtain the full sequence and mRNA sequence, use existing network resources and commonly used software to conduct biological analysis on AXIIR, and select the coding region as the target sequence for siRNA design. Refer to the siRNA design principle, and compare it with the human genome sequence through the blast function of the GeneBank database to ensure that there is no homology; exclude potential siRNAs that have 8 consecutive bases at the 5' end of the aitisense chain paired with other genes; exclude any consecutive 14 bases base-pairing potential siRNAs with other genes. The design software was used for pre-evaluation and determination, and three targets with the best kinetic parameters were selected to enter the subsequent experimental process. A total of three interference sequences were synthesized for each ge...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the technical field of biomedicine, in particular to a new target for resisting enterovirus 71 infection and its application. In the present invention, human colon cancer cells (Caco-2) are used as target cells, and RNA interference technology is used to down-regulate the expression of target cell membrane receptors to find host factors that can effectively inhibit EV71 from infecting human colon cancer cells. The purpose of blocking EV71 infection. The present invention finds through experiments that interleukin 4 receptor (IL4R) plays an important role in the infection of Caco-2 cells by EV71, and down-regulates the expression of IL4R, which can obviously inhibit the infection of EV71. The invention provides the application of IL4R in the preparation of drugs for the prevention or treatment of enterovirus 71 infection, which provides clinical prevention and treatment of diseases such as hand, foot and mouth disease, meningitis, brainstem encephalitis or polio caused by EV71 infection. new targets and treatment options.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular, a new target and application for resisting enterovirus 71 infection. Background technique [0002] Enterovirus 71 (enterovirus 71, EV71) belongs to the picornaviridae enterovirus and belongs to human enterovirus A, and is one of the main pathogens causing hand-foot-mouth disease (HFMD). Currently, hand, foot and mouth disease is breaking out and spreading in many parts of the world, especially in the Asia-Pacific region. The main patients with HFMD are infants and young children under 5 years old. The clinical manifestations are fever, herpes and other symptoms on the hands, feet, buttocks and oral mucosa; a small number of children can develop into severe patients with central nervous system (central nervous system , CNS) lesions, including aseptic meningitis, brainstem encephalitis, encephalomyelitis, and neurogenic pulmonary edema, which seriously threaten the life and heal...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61P31/14
CPCA61K45/00A61P31/14
Inventor 戚中田王晓航鲍诗骏朱勇喆刘延刚赵平
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap