Nanogold-plugged mesoporous silicon controlled release system

A technology of drug controlled release and mesoporous silicon, which is applied in drug combinations, antineoplastic drugs, pharmaceutical formulations, etc., can solve the problems of inability to detect tumor growth and the inability to grasp the dosage, and achieve real-time monitoring of growth, The effect of convenient administration

Inactive Publication Date: 2019-12-27
HUBEI UNIV
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this specific treatment also has certain limitations. It cannot detect the growth of tumors in the body, and cannot grasp the dosage

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nanogold-plugged mesoporous silicon controlled release system
  • Nanogold-plugged mesoporous silicon controlled release system
  • Nanogold-plugged mesoporous silicon controlled release system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] A method for preparing a nano-gold plugged mesoporous silicon drug controlled release system, specifically comprising the following steps:

[0062] 1. Preparation of near-infrared emitting carbon dot nanoparticles (CDs):

[0063] Weigh 0.6g of glutathione and 19.4g of formamide, mix them ultrasonically for 30min, add them into a 50mL polytetrafluoroethylene liner, put them into a 50mL polytetrafluoroethylene autoclave, and react at 160°C for 10h. After it cools naturally, dilute the above product with 20mL deionized water, and then dialyze with a dialysis bag with a molecular weight of 3500 for two days, then filter the product with a 0.22 micron microporous membrane, and finally spin evaporate the product under vacuum at 60°C After drying for 12 hours, near-infrared emitting carbon dots were obtained.

[0064] Depend on figure 1 It can be seen that the near-infrared carbon dots have a particle size range of 3-5 nm and are uniformly dispersed nanospheres. Depend on ...

Embodiment 2

[0082] A method for preparing a nano-gold plugged mesoporous silicon drug controlled release system, specifically comprising the following steps:

[0083] 1. Prepare near-infrared emitting carbon dot nanoparticles (CDs): same as Example 1;

[0084] 2. Preparation of silylated carbon dot nanoparticles (CDs-IPTS): same as Example 1;

[0085] 3. Preparation of mesoporous silicon nanoparticles wrapped with carbon dots (CDs@MSNs):

[0086] After dissolving 3.5 mg of CDs-IPTS prepared in step 2 in 4 mL of deionized water, ultrasonically mixed with 1.5 mL of tetraethylorthosilicate (TEOS) to obtain a mixed solution;

[0087] Separately weigh 0.5g of cetyltrimethylammonium chloride (CTAC), measure 180 microliters of triethylamine (TEA), dissolve it in 20mL of deionized water, raise the temperature to 80°C while stirring, and slowly add the above The mixed solution was condensed and refluxed at 80°C for 1 h. After the reaction, 100 mL of ethanol was added, and then centrifuged (10,00...

Embodiment 3

[0096] A preparation method of a nano-gold plugged mesoporous silicon drug controlled release system, specifically comprising the following steps

[0097] 1. Prepare near-infrared emitting carbon dot nanoparticles (CDs): same as Example 1;

[0098] 2. Preparation of silylated carbon dot nanoparticles (CDs-IPTS): same as Example 1;

[0099] 3. Preparation of mesoporous silicon nanoparticles (CDs@MSNs) wrapped with carbon dots: the same as in Example 2;

[0100] 4. Preparation of amino-functionalized carbon-dot mesoporous silicon nanoparticles (CDs@MSNs-NH 2 ):

[0101] Weigh 200mg of CDs@MSNs and dissolve in 100mL of ethanol, add 1.8mL of 3-aminopropyltriethoxysilane (APTES) after ultrasonic dispersion, reflux at 50°C for 12h, and then centrifuge (10000rpm / min×10min) to precipitate , washed with deionized water and ethanol three times repeatedly, and then freeze-dried for later use.

[0102] 5. Preparation of carbon-dot mesoporous silicon grafted with triphenylphosphine (TP...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to view more

Abstract

The invention discloses a nanogold-plugged mesoporous silicon controlled release system. carbon dots emitted by near infrared light are used for a matrix for silane coupling to obtain silanized carbondots; then, the silanized carbon dots are used as a core to produce hollow mesoporous silicon with fluorescence imaging performance, then, the surface of the hollow mesoporous silicon is modified with amino and reacts with (3-carboxypropyl)triphenylphosphonium bromide, doxorubicin drug is carried during continuous carrying of the (3-carboxypropyl)triphenylphosphonium bromide, and finally, pores of the hollow mesoporous silicon are packaged under the electrostatic effect of nanogold. Compared with a traditional drug carrying material, the drug controlled release system has the bioimaging performance, and can perform real-time monitoring and effectively increase the drug utilization rate.

Description

technical field [0001] The invention specifically relates to a nano-gold plugged mesoporous silicon medicine controlled release system, which belongs to the field of biomedical polymers. Background technique [0002] Cancer is the most devastating disease in the world, and chemotherapy is currently one of the most widely used treatments to cure cancer. However, in conventional cancer chemotherapy, while highly toxic drugs act on the whole body and cause strong toxic and side effects, the efficacy of tumor drugs is greatly reduced. In fact, strong toxic side effects and low chemotherapy effect have become one of the main causes of death of cancer patients. [0003] Over the past few decades, targeted drug delivery systems have attracted considerable attention for their selective drug delivery to tumor tissues. However, targeted drug delivery systems still have certain limitations because cytotoxic drugs release unwanted drugs before they reach the affected site, so an ideal...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K31/704A61K47/04A61K47/69A61K47/02A61P35/00
CPCA61K31/704A61K47/02A61K49/005A61K49/0067A61K47/6949A61P35/00
Inventor 许子强何航张书媛李草陈学琴江兵兵
Owner HUBEI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap