Application of tetracera asiatica roots and extract thereof in preparation of medicine for treating and/or preventing chemical liver injury

A technology of sycamore and its extracts, which is applied in the field of pharmaceutical applications, can solve the problems of sycamore and its extracts, and achieve the effect of restoring protein synthesis function, good chemical resistance, and reducing the degree of

Inactive Publication Date: 2020-02-14
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the application of safflower and its extracts in the preparation of drugs for the treatment and / or prevention of chemical liver damage

Method used

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  • Application of tetracera asiatica roots and extract thereof in preparation of medicine for treating and/or preventing chemical liver injury
  • Application of tetracera asiatica roots and extract thereof in preparation of medicine for treating and/or preventing chemical liver injury
  • Application of tetracera asiatica roots and extract thereof in preparation of medicine for treating and/or preventing chemical liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation of embodiment 1 sycamore water extract

[0040] Tin leaf vine was collected in Wuming Gaofeng Forest Farm, Guangxi, and was identified as the stem of Tetracera asiatica (Lour.) Hoogland by Associate Professor Teng Jianbei of Guangxi University of Traditional Chinese Medicine. Take 200g of pulverized vine powder, add 5000mL of pure water each time, decoct at 100°C for 1 hour, repeat 3 times, combine the extracts obtained 3 times, concentrate into water extract extract, make each 1g of water extract The crude drug content in the ointment is 7.0771g.

Embodiment 2

[0041] The preparation of embodiment 2 tin yetogen alcohol extract

[0042] Tin leaf vine was collected in Wuming Gaofeng Forest Farm, Guangxi, and was identified as the stem of Tetracera asiatica (Lour.) Hoogland by Associate Professor Teng Jianbei of Guangxi University of Traditional Chinese Medicine. Take 100 g of the pulverized vine medicinal powder, add 2500 mL each time, 50% ethanol, reflux extraction in a water bath at 80° C. for 1 h, repeat 3 times, combine the obtained extracts for 3 times, concentrate to obtain the ethanol extract of vine vine, and make 1g of alcohol extract contains 6.9638g of crude drug.

Embodiment 3

[0043] The preparation of embodiment 3 vine ethyl acetate extract, n-butanol extract

[0044] Get the alcohol extract extract obtained in Example 2, disperse it in 50% ethanol, and use ethyl acetate to continuously extract 15 times, each 50mL, and the extracts are combined to obtain the extract of the vine ethyl acetate extract; Continuously extract 15 times with n-butanol, 50 mL each time, and combine the extracts to obtain the extract of n-butanol extract of Cinnamomum chinensis. Concentrate at 80 DEG C subsequently, make the crude drug content of 1g ethyl acetate extract extract be 52.0833g, make the crude drug content of 1g n-butanol extract extract be 41.6667g.

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Abstract

The invention relates to the field of medicine application, in particular to an application of tetracera asiatica roots and an extract thereof in preparation of a medicine for treating and/or preventing chemical liver injury. The tetracera asiatica root extract is selected from any one or a mixture of more than one of the following components: a tetracera asiatica root water extract, a tetracera asiatica root alcohol extract, a tetracera asiatica root ethyl acetate extract and a tetracera asiatica root n-butyl alcohol extract. The tetracera asiatica root extract provided by the invention can obviously increase the albumin content of serum of CCl4 acute liver injury mouse, and improves the albumin synthesis capacity of the liver by repairing endoplasmic reticulum, Golgi body, ribosome and the like of injured cells, thereby providing protection for the liver.

Description

technical field [0001] The invention relates to the field of medicine application, in particular to the application of sycamore and its extract in the preparation of medicines for treating and / or preventing chemical liver damage. Background technique [0002] Tin leaf vine is the root of Tetracera asiatica (Lour.) Hoogland. It is cool in nature, bitter in taste, has the functions of restraining diarrhea, reducing swelling and relieving pain. Commonly used in the treatment of diarrhea, dysentery, proctoptosis and other diseases. Its medicinal materials are rich in tannins, flavonoids, terpenoids and other biologically active ingredients, which have obvious antibacterial, anti-inflammatory, anti-tumor activities [State Administration of Traditional Chinese Medicine Chinese Materia Medica Editorial Committee. Zhonghua Materia Medica [M ]. Volume 3. Shanghai: Shanghai Science and Technology Press, 1999: 510-511.]. Tin leaf vine is rich in medicinal resources, and it is produc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P1/16A61K125/00
CPCA61K36/185A61K2236/331A61K2236/333A61P1/16
Inventor 朱华笪舫芳戴忠华张淼樊柳园李鹏何瑞婷
Owner GUANGXI UNIV OF CHINESE MEDICINE
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