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Chinese angelica milkvetch root blood-nourishing oral liquid and preparation method thereof

A technology of Guiqi oral liquid and oral liquid, which is applied in the field of Guiqi nourishing blood traditional Chinese medicine preparations, can solve the problems of low ferulic acid content and low ferulic acid extraction and transfer rate, so as to reduce the loss of ferulic acid and reduce the loss, the effect of ensuring product quality

Inactive Publication Date: 2020-02-21
中山市恒生药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the defects and deficiencies of the low extraction and transfer rate of active ingredient ferulic acid in the existing Guiqi Yangxue preparation and the low content of ferulic acid in the preparation, and provide a Guiqi Yangxue oral liquid preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A preparation method of Guiqi Yangxue oral liquid, described Guiqi oral liquid is composed of Angelica 120g, Rhizoma Cyperi (manufactured) 20g, Codonopsis pilosula (honey roasted) 20g, Radix Astragali (honey roasted) 20g, Rhizoma Chuanxiong (made) 20g , Radix Paeoniae Alba (system) 20g, Rehmannia glutinosa 40g, Radix Glycyrrhizae (honey roasted) 20g, Poria cocos 20g form, and its preparation method comprises the steps:

[0043] S1. Take the Angelica sinensis and Ligusticum chuanxiong mentioned above, grind them into 30-mesh coarse powder with a pulverizer, carry out percolation with 70% ethanol as solvent, the percolation discharge rate is 2mL / kg medicinal materials min, collect percolation liquid, and collect for 12 minutes in total;

[0044] S2. Combine the dregs of Angelica sinensis and Ligusticum chuanxiong after percolation in S1, add water to 3000mL with the remaining Qiwei medicinal materials, and perform countercurrent extraction. The extraction temperature is 60...

Embodiment 2

[0049] A preparation method of Guiqi Yangxue oral liquid, described Guiqi oral liquid is composed of Angelica 120g, Rhizoma Cyperi (manufactured) 20g, Codonopsis pilosula (honey roasted) 20g, Radix Astragali (honey roasted) 20g, Rhizoma Chuanxiong (made) 20g , Radix Paeoniae Alba (system) 20g, Rehmannia glutinosa 40g, Radix Glycyrrhizae (honey roasted) 20g, Poria cocos 20g form, and its preparation method comprises the steps:

[0050] S1. Take the above-mentioned Chinese angelica and Rhizoma Chuanxiong, grind them into 20-mesh coarse powder with a pulverizer, and carry out percolation with 70% ethanol as the solvent.

[0051] S2. Combine the dregs of Angelica sinensis and Ligusticum chuanxiong after percolation in S1, add water to 3000mL with the other Qiwei medicinal materials, and perform countercurrent extraction, the extraction temperature is 50°C, and the extraction time is 70min; the extraction filtrate is concentrated under reduced pressure at 50°C, to extract the extra...

Embodiment 3

[0056] A preparation method of Guiqi Yangxue oral liquid, described Guiqi oral liquid is composed of Angelica 120g, Rhizoma Cyperi (manufactured) 20g, Codonopsis pilosula (honey roasted) 20g, Radix Astragali (honey roasted) 20g, Rhizoma Chuanxiong (made) 20g , Radix Paeoniae Alba (system) 20g, Rehmannia glutinosa 40g, Radix Glycyrrhizae (honey roasted) 20g, Poria cocos 20g form, and its preparation method comprises the steps:

[0057] S1. Take the above-mentioned Chinese angelica and Rhizoma Chuanxiong, grind them into a 10-mesh coarse powder with a pulverizer, use 70% ethanol as a solvent to percolate, and the percolation discharge rate is 3mL / kg medicinal material min, collect the percolation liquid, and collect it for 10 minutes;

[0058] S2. Combine the dregs of Angelica sinensis and Ligusticum chuanxiong in S1 with the rest of the Qiwei medicinal materials and add water to 3000mL for countercurrent extraction. The design extraction temperature is 70°C and the extraction ti...

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Abstract

The invention discloses a Chinese angelica milkvetch root blood-nourishing oral liquid and a preparation method thereof. The preparation method comprises the following steps: taking Chinese angelica and rhizoma ligustici Chuanxiong, performing crushing, performing ethanol percolation extraction, and collecting a percolation solution; merging percolation medicine residues and other seven medicinalmaterials, adding water, and performing countercurrent extraction to obtain extractive extract; adding ethanol into the extract, allowing the solution to stand, separating the supernatant, and performing reduced-pressure concentration to obtain clear paste; and diluting the clear paste, taking the supernatant, adding the percolation solution, performing uniform mixing, adding sucrose, Tween-80 andsorbic acid, performing uniform stirring, adding purified water, performing uniform stirring to obtain a formula liquid, performing refined filtration, performing potting, and performing sterilization treatment to obtain the Chinese angelica milkvetch root blood-nourishing oral liquid. According to the preparation method, through the percolation process and the countercurrent extraction, ferulicacid in the medicinal materials is extracted completely to the utmost extent, the loss of the ferulic acid is reduced, and the ethanol content of the product can be greatly reduced; and low-temperature concentration and sterilization treatment further reduce the loss of the ferulic acid, clouding formation of the product is avoided, the stable product quality is ensured, and the ferulic acid content reaches 0.97-1.32 mg / 15 mL.

Description

technical field [0001] The invention relates to the technical field of Guiqi nourishing blood traditional Chinese medicine preparations, and more specifically relates to Guiqi nourishing blood oral liquid and a preparation method thereof. Background technique [0002] Guiqi Yangxue Oral Liquid is a Chinese patent medicine with the function of regulating menstruation and nourishing blood. It is used for irregular menstruation, anemia, dizziness, and postpartum anemia and weakness. Due to its good curative effect and convenient administration, this product has been widely used in the treatment of the above diseases. The product prescription consists of 120g of angelica, 20g of Rhizoma Cyperi (made), 20g of Codonopsis (honey-roasted), 20g of Astragalus (made of honey), 20g of Chuanxiong (made of), 20g of white peony (made of), 40g of Rehmannia glutinosa, and licorice (made of honey). 20g, Poria cocos 20g, composed of nine traditional Chinese medicines. The existing preparation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61K9/08A61K47/26A61P7/06A61P15/00
CPCA61K36/232A61K36/8905A61K36/344A61K36/481A61K36/236A61K36/71A61K36/65A61K36/804A61K36/484A61K36/076A61K9/0095A61K47/26A61P15/00A61P7/06A61K2236/331A61K2236/55
Inventor 唐琳何贵全劳悦富赵雪婷陆如满李海燕成金乐徐吉银王义娜
Owner 中山市恒生药业有限公司
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