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Stochastic stimulation to improve infant respiration

A technology of mechanical stimulation and respiratory function, applied in artificial respiration, evaluation of respiratory organs, applications, etc., can solve problems such as delayed infant cognitive and executive development, prolonged hospital stay, infant injury, etc.

Pending Publication Date: 2020-04-24
PRESIDENT & FELLOWS OF HARVARD COLLEGE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even if not fatal, apneic events and poor respiratory function are considered to have many adverse consequences, such as prolonging the hospital stay, delaying the infant's cognitive and executive development, or even causing irreparable harm to the infant

Method used

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  • Stochastic stimulation to improve infant respiration
  • Stochastic stimulation to improve infant respiration
  • Stochastic stimulation to improve infant respiration

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Embodiment Construction

[0053] Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Szycher's Dictionary of Medical Devices (CRC Press, 1995) can provide a useful guide to many of the terms and phrases used in this text. One skilled in the art will recognize many methods and materials similar or equivalent to those described herein, which could be used in the practice of the present invention. Indeed, the invention is in no way limited to the methods and materials specifically described.

[0054] In some embodiments, properties such as size, shape, relative position, etc., used to describe and claim certain embodiments of the present invention are to be understood as modified by the term "about".

[0055] Various examples of the invention have been described. The following description provides specific details for a thorough understanding and conditional completion of th...

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Abstract

The inventors have developed systems and methods for providing stochastic stimulus to patients to improve their respiration. For instance, the inventors have discovered that ventilated infants improvetheir breathing including by reducing the total amount of desaturation during periods of stochastic, mechanical stimulation. It was previously thought that stochastic stimulation only improved breathing by encouraging active pacemaker activity. Accordingly, the inventors have developed systems and methods that improves infant respiration.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Patent Application No. 62 / 546,401, filed August 16, 2017, entitled "Stochastic Stimulation to Improving Infant Respiration," the contents of which are incorporated herein by reference. [0003] Statement Regarding Federally Sponsored Research [0004] This invention was made with government support under Grant No. IIS-1401711 awarded by the National Science Foundation. The Government has certain rights in this invention. technical field [0005] The present invention relates to methods and systems for improving infant breathing using random stimuli. Background technique [0006] Infants often have an irregular breathing pattern with periodic and sporadic pauses in breathing, more commonly known as "apnea". One way to analyze breathing patterns is to use the time interval between breaths, also known as the "inter-breath interval" or "IBI". [0007] Preterm infants have highly...

Claims

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Application Information

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IPC IPC(8): A61B5/00A61B5/01A61B5/0205A61B5/03A61B5/08A61F5/56A61H1/00A61H23/02
CPCA61B5/726A61B5/7264A61B5/01A61B5/0205A61B5/02108A61H23/02A61B5/0816A61B5/082A61B5/14542A61B5/4818A61B5/4836A61B2503/04A61B2562/0219A61B2562/0261A61H31/00A61H2201/0146A61H2201/0173A61H2201/1207A61H2201/1619A61H2201/1635A61H2201/164A61H2201/165A61H2201/5007A61H2201/5058G16H50/20A61B5/6804A61B5/6891A61B5/725
Inventor J·B·尼米D·佩达法
Owner PRESIDENT & FELLOWS OF HARVARD COLLEGE
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