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Internal ultraviolet therapy

A technology of ultraviolet light and therapy, which is applied in the system field of ultraviolet light therapy in the body, and can solve problems such as suboptimal disease treatment

Pending Publication Date: 2022-05-27
CEDARS SINAI MEDICAL CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Despite significant advances over the past few decades, treatment of these diseases remains suboptimal

Method used

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Examples

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example 1

[0230] Example 1: E. coli

[0231] Figure 12A and Figure 12B Experimental data showing an example of a UV emitting device of the present disclosure for preventing E. coli proliferation is shown. As shown, the control group with no UV light applied continued to grow, while the test group with UV light applied through the UV emitting device showed a continued decrease in the number of E. coli over time. UV light was shown to both prevent E. coli proliferation and kill bacteria over time.

[0232] Figure 15B An example of a UV emitting device of the present disclosure for a liquid culture containing E. coli is shown. For example, the results of this and similar experiments with other bacteria and fungi, Candida albicans, are shown in Figure 15A and Figure 16 , 17A-17B , Figure 18-Figure 20 , Figure 21A and Figure 21B middle. All results demonstrate a significant reduction in the growth of E. coli and other infectious pathogens in liquid samples to which UV-A...

example 2

[0233] Example 2: Bacteria

[0234] In another example, two exemplary devices according to the present disclosure were used in UVA experiments to treat bacteria. The first device was a borosilicate rod (3 mm outer diameter) etched repeatedly with a mixture of dilute sulfuric acid, sodium bifluoride, barium sulfate and ammonium bifluoride, with a reflective coating added to the end of the rod through which UVA was emitted sideways. This process produced side glow sticks of UVA (peak wavelength 345 nm) as demonstrated by a spectrometer (Ocean Optics; Extech). The second device incorporates narrow-band LEDs with a peak wavelength of 345 nm.

[0235]UVA rods were inserted into the liquid medium. A mercury vapor lamp was used as a light source (Asahi Max 303, Asahi Spectra Co., Tokyo, Japan). The second UVA light emitting device was an array of miniature light emitting diodes (LEDs) (peak wavelength 345 nm) mounted on a heat sink (Seoul Viosys, Gyeonggi-Do, Korea). This appar...

example 3

[0253] Example 3: Secure Data

[0254] To assess the safety of UVA on mammalian cells, three experiments were performed. The first is to expose UVA to HeLa cells in culture. HeLa cells were added to DMEM cell culture medium (Gibco, Waltham, MA) plus 10% bovine serum (Omega Scientific, Tarzana, CA) and 1x antimycin (100x Gibco) in 60x15mm cell culture dishes (Falcon), and at 37°C (5%CO 2 ) for 24 hours to reach 1,000,000 to 1,800,000 cells per plate. At this point, cells were exposed to UVA LED light (1800 μW / cm 2 ) for 0 (control), 10 or 20 minutes. After 24 hours, cells were removed with 0.05% trypsin (Trypsin-EDTA) (1x) (Gibco), stained with Trypan Blue 0.4% ready-to-use (1:1) (Gibco) and passed through automated cells A counter (Biorad T20, Hercules, CA) was used for quantification. In a similar experiment, a higher intensity (5000 μW / cm 2) LED UVA light for 20 minutes. Again, the number of HeLa cells was measured 24 h after UVA exposure.

[0255] The safety of U...

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Abstract

The present invention provides a UV light delivery device for performing in vivo UV therapy. The device includes an elongate body separated by a proximal end and a distal end. The apparatus also includes a UV light source configured to be received in the receiving space. In some examples, the UV light source is configured to emit light at a wavelength having a significant intensity between 320 nm and 410 nm, and is used in conjunction with an endotracheal tube or nasopharyngeal airway.

Description

[0001] Related applications [0002] This application claims US Provisional Application 62 / 915,448, filed October 15, 2019, and US Provisional Application 62 / 992,861, filed March 20, 2020, both titled INTERNAL ULTRAVIOLET THERAPY, 2020 Priority of US Provisional Application 62 / 993,595, filed March 23, US Provisional Application 63 / 000,788, filed March 27, 2020, and US Provisional Application 63 / 012,727, filed April 20, 2020, the contents of which Incorporated herein by reference. technical field [0003] The present invention relates to systems and methods for in vivo UV therapy. Background technique [0004] The following description includes information that may be helpful in understanding the present invention. This is not an admission that any of the information provided herein is prior art or related to the presently claimed invention, or that any publications specifically or implicitly referenced are prior art. [0005] Infectious, immune-mediated and inflammatory d...

Claims

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Application Information

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IPC IPC(8): A61N5/06
CPCA61N5/0603A61N2005/0608A61N2005/0611A61N2005/0604A61N2005/0609A61N2005/061A61N5/0624A61N2005/0661A61N2005/0652
Inventor 阿里·列扎耶马克·皮门特尔吉尔·Y·梅勒德鲁奇·马图尔加布里埃拉·吉马拉斯·苏萨·莱特
Owner CEDARS SINAI MEDICAL CENT
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