Selenic acid esterified Polygonatum odoratum polysaccharide and preparation method thereof

A polysaccharide and selenate technology from Polygonatum polysaccharides, applied in the direction of anti-toxic agents, drug combinations, etc., to achieve the effect of slowing down the rising trend of POV value

Inactive Publication Date: 2020-04-28
WUHAN POLYTECHNIC UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] At present, there is no research on the use of polysaccharides from Polygonatum polysaccharides for selenate esterification. It is worth noting that the molecular weight of polysaccharides from Polygonatum polysaccharides is smaller than that of other plant polysaccharides, and the molecular weight is often inversely proportional to the degree of substitution and biological activity. The application of selenoesterified Polygonatum Polysaccharides in antioxidant research will surely provide new ideas and references for the biological activity of polysaccharides

Method used

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  • Selenic acid esterified Polygonatum odoratum polysaccharide and preparation method thereof
  • Selenic acid esterified Polygonatum odoratum polysaccharide and preparation method thereof

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Embodiment 1

[0032] This embodiment provides a preparation method of selenate-esterified polygonatum polysaccharide, comprising the following steps:

[0033] 1) Precisely weigh 0.5g Polygonatum polysaccharide and place it in a three-necked flask, add a certain concentration of HNO 3 Solution 50mL, heated and stirred to dissolve the polysaccharide completely, and obtain Polygonatum polysaccharide solution with a concentration of 5mg / mL;

[0034] 2) Step 1) Polygonatum polysaccharide solution adjusts the temperature of the water bath to the set value, and adds a certain amount of Na 2 SeO 3 , so that the polysaccharide and Na 2 SeO 3 When the ratio of the two raw materials reaches the set value, add 0.5g BaCl 2 Respond to the set time;

[0035] 3) Step 2) After the reaction is over, the reaction solution is naturally cooled to room temperature, filtered with suction, and an appropriate amount of 5% Na is added to the filtrate 2 SeO 3 , so that Ba 2+ After the precipitation is complet...

Embodiment 2

[0041] This embodiment provides a preparation method of selenate-esterified polygonatum polysaccharide, comprising the following steps:

[0042] 1) Precisely weigh 1.0g Polygonatum polysaccharide and place it in a three-necked flask, add a certain concentration of HNO 3 Solution 100mL, heat and stir to dissolve the polysaccharide completely, and obtain Polygonatum polysaccharide solution with a concentration of 10mg / mL;

[0043] 2) Step 1) Polygonatum polysaccharide solution adjusts the temperature of the water bath to the set value, and adds a certain amount of Na 2 SeO 3 , so that the polysaccharide and Na 2 SeO 3 When the ratio of the two raw materials reaches the set value, add 1.5g BaCl 2 Respond to the set time;

[0044] 3) Step 2) After the reaction is over, the reaction solution is naturally cooled to room temperature, filtered with suction, and an appropriate amount of 10% Na is added to the filtrate 2 SeO 3 , so that Ba 2+ After the precipitation is complete,...

Embodiment 3

[0050] This embodiment provides a preparation method of selenate-esterified polygonatum polysaccharide, comprising the following steps:

[0051] 1) Precisely weigh 5g Polygonatum polysaccharide and place it in a three-necked flask, add a certain concentration of HNO 3 Solution 150mL, heat and stir to dissolve the polysaccharide completely, and obtain Polygonatum polysaccharide solution with a concentration of 15mg / mL;

[0052] 2) Step 1) Polygonatum polysaccharide solution adjusts the temperature of the water bath to the set value, and adds a certain amount of Na 2 SeO 3 , so that the polysaccharide and Na 2 SeO 3 When the ratio of the two raw materials reaches the set value, add 3g BaCl 2 Respond to the set time;

[0053] 3) Step 2) After the reaction is over, the reaction solution is naturally cooled to room temperature, filtered with suction, and an appropriate amount of 15% Na is added to the filtrate 2 SeO 3 , so that Ba 2+ After the precipitation is complete, cen...

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Abstract

The invention belongs to the technical field of polysaccharide preparation, and relates to selenic acid esterified Polygonatum odoratum polysaccharide and a preparation method thereof. The method comprises the following steps: extraction of a Polygonatum odoratum polysaccharide solution, reaction of polysaccharide and Na2SeO3, Ba<2+> precipitation, esterification of Polygonatum odoratum polysaccharide with selenic acid and the like. Polygonatum odoratum polysaccharide and sodium selenite are used as raw materials; the selenium content and the yield of a synthetic product are used as inspectionindexes; the raw material ratio, the reaction temperature, the nitric acid concentration and the reaction time are taken as preparation parameters, and the synthesis process conditions of the Polygonatum odoratum polysaccharide selenate are optimized; the selenic acid esterified Polygonatum odoratum polysaccharide is subjected to antioxidant research, and the result shows that the maximum scavenging rate of the selenic acid esterified polygonatum odoratum polysaccharide to Fe<2+> is 22%; the selenic acid esterified Polygonatum odoratum polysaccharide also has a certain scavenging capability on superoxide anion free radicals, and the maximum scavenging rate is 17%, so that a theoretical basis is provided for full development and utilization of Polygonatum odoratum resources.

Description

technical field [0001] The invention belongs to the technical field of polysaccharide preparation, and more specifically relates to a selenate-esterified Polygonatum polysaccharide and a preparation method thereof. Background technique [0002] Selenium is a trace element required for the life activities of animals and plants, and it mainly exists in enzymes, such as glutathione peroxidase, thioredoxin reductase and formate dehydrogenase. According to relevant statistics, about 1 billion people in the world may suffer from insufficient selenium intake, and some diseases are related to selenium deficiency, such as viral diseases, cardiovascular sclerosis and diabetes. [0003] Selenium mainly exists in two forms: inorganic selenium and organic selenium. Compared with inorganic selenium, organic selenium has a relatively higher bioavailability because it is easier to be absorbed in the human digestive tract and excreted in human urine. At present, inorganic selenium includes ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61P39/06
CPCA61P39/06C08B37/0003C08B37/006
Inventor 常超李明王晓梦李漫吴麦玲白金
Owner WUHAN POLYTECHNIC UNIVERSITY
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